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ClinicalTrials.gov public records Last synced Jul 21, 2026, 11:31 AM EDT

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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Chronic Total Occlusion Clear all
Completed Not applicable Interventional Results available

ReFlow Medical Wingman Catheter Wing-IT Clinical Trial

NCT03403426
View directory record Official record
Conditions
Chronic Total Occlusion of Artery of the Extremities
Interventions
Wingman Crossing Catheter
Device
Lead sponsor
ReFlow Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
St. Helena, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Jul 21, 2026, 11:31 AM EDT
Completed No phase listed Observational

In-hospital and Long-term Outcomes for Percutaneous Chronic Total Coronary Occlusion Revascularization in a High-volume, Multi-operator Program

NCT01946724
View directory record Official record
Conditions
Ischemic Heart Disease
Interventions
Not listed
Lead sponsor
Piedmont Healthcare
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 1, 2019 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated Phase 2 Interventional Results available

The Lumen Study: Comparing Devices for Patients With Symptomatic Femoro-popliteal Chronic Total Occlusion (CTO)

NCT02145299
View directory record Official record
Conditions
Symptomatic Femoro-popliteal Chronic Total Occlusion
Interventions
TruePath CTO Device, CROSSER CTO Device
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 100 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Not applicable Interventional Results available

EXPERT CTO: Evaluation of the XIENCE PRIME™ LL and XIENCE Nano™ Everolimus Eluting Coronary Stent Coronary Stents, Performance, and Technique in Chronic Total Occlusions

NCT01435031
View directory record Official record
Conditions
Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO)
Interventions
CTO Treatment Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Santa Clara, California
Source: ClinicalTrials.gov public record
Updated May 8, 2018 · Synced Jul 21, 2026, 11:31 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation Inhaled Corticosteroids on Exhaled Nitric Oxide Gas Exchange

NCT00568347
View directory record Official record
Conditions
COPD
Interventions
fluticasone 100mcg/ salmeterol 50mcg, fluticasone 250/salmeterol 50, Salmeterol, salmeterol and fluticasone propionate
Drug
Lead sponsor
Arthur F Gelb MD
Individual
Eligibility
20 Years to 85 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2013
U.S. locations
1
States / cities
Lakewood, California
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Jul 21, 2026, 11:31 AM EDT
Enrolling by invitation Not applicable Interventional

Acolyte CTO-PCI Study: Imaging and Catheter System to Treat Patients With Coronary Chronic Total Occlusion, Who Have Persistent Symptoms Following Medical Therapy and Are Undergoing Percutaneous Coronary Interventional Procedures

NCT06795763
View directory record Official record
Conditions
Coronary Chronic Total Occlusions, Ischemic Heart Disease, Ischemic Heart Disease (IHD), Ischemic Heart Disease Chronic
Interventions
CTO-PCI Procedure with Acolyte Catheter System
Device
Lead sponsor
Elumn8 Medical
Industry
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
5
States / cities
Atlanta, Georgia • Minneapolis, Minnesota • Roslyn, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Jul 21, 2026, 11:31 AM EDT
Not listed No phase listed Observational

Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

NCT02061436
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
42
States / cities
Phoenix, Arizona • Little Rock, Arkansas • San Diego, California + 31 more
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 4 Interventional Results available

PENG Block Versus LP Block for THA Postop Pain

NCT05261009
View directory record Official record
Conditions
Pain, Postoperative, Hip Pain Chronic
Interventions
Peri-capsular Nerve Group (PENG), Lumbar Plexus Block (LPB)
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 4 Interventional

Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial

NCT02510547
View directory record Official record
Conditions
Arteriosclerosis, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
Interventions
CrossBoss Catheter, Antegrade Wire Escalation Strategy
Procedure
Lead sponsor
North Texas Veterans Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
246 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
11
States / cities
Boston, Massachusetts • Detroit, Michigan • Minneapolis, Minnesota + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 24, 2018 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 1 Interventional

Imaging of Totally Blocked Arteries

NCT00459446
View directory record Official record
Conditions
Atherosclerosis, Peripheral Artery Disease, Intermittent Claudication, Chronic Total Aterial Occlusion
Interventions
MS-325 Injection (Gadofosveset Trisodium)
Drug
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Not applicable Interventional

STAR and Deferred Stenting Study

NCT05089864
View directory record Official record
Conditions
Coronary Occlusion, Coronary Stenosis, Coronary Restenosis
Interventions
Stent Placement Timing - Early, Stent Placement Timing - Late
Other
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 23, 2025 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated No phase listed Observational

Impact of CTO PCI (Chronic Total Occlusion Percutaneous Intervention) on Regular Physical Activity

NCT05440084
View directory record Official record
Conditions
Chronic Total Occlusion, Occlusion
Interventions
Chronic total occlusion percutaneous coronary intervention
Procedure
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated Not applicable Interventional

Excellence in Peripheral Arterial Disease Treatment of Superficial Femoral Artery Disease With Drug-eluting Stents

NCT03671655
View directory record Official record
Conditions
Peripheral Vascular Diseases, Chronic Total Occlusion of Artery of the Extremities
Interventions
Drug-eluting stent, Bare metal stent
Device
Lead sponsor
North Texas Veterans Healthcare System
Federal
Eligibility
18 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 13, 2018 · Synced Jul 21, 2026, 11:31 AM EDT
Completed No phase listed Observational

Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion

NCT02026466
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Not listed
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
11
States / cities
Mesa, Arizona • Phoenix, Arizona • Torrance, California + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2021 · Synced Jul 21, 2026, 11:31 AM EDT
Not listed Not applicable Interventional

Treatment of Calcific Total Occlusions in Peripheral Artery Disease

NCT05551780
View directory record Official record
Conditions
Chronic Total Occlusion of Artery of the Extremities
Interventions
SoundBite Crossing System
Device
Lead sponsor
SoundBite Medical Solutions, Inc.
Industry
Eligibility
19 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
3
States / cities
Fort Lauderdale, Florida • Raleigh, North Carolina • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 12, 2024 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated Not applicable Interventional

Safety and Efficacy Study of the SoundBite™ Crossing System With ACTIVE Wire in Coronary CTOs.

NCT03521804
View directory record Official record
Conditions
Chronic Total Occlusion of Coronary Artery
Interventions
SoundBite™ Crossing System Active Wire 14
Device
Lead sponsor
SoundBite Medical Solutions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 5, 2023 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 3 Interventional

ACROSS-Cypher Total Occlusion Study of Coronary Arteries 4 Trial

NCT00378612
View directory record Official record
Conditions
Coronary Occlusions
Interventions
Cypher sirolimus eluting coronary stent
Device
Lead sponsor
Sunil Rao
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2012
U.S. locations
13
States / cities
La Jolla, California • Washington D.C., District of Columbia • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2014 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

REduction of Contrast Via DyeVert Used in CTO Procedures

NCT03118544
View directory record Official record
Conditions
Chronic Total Occlusion of Coronary Artery
Interventions
DyeVert System
Device
Lead sponsor
Minneapolis Heart Institute Foundation
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
3
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 16, 2018 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Not applicable Interventional Results available

The Asahi Intecc PTCA Chronic Total Occlusion Study

NCT02379923
View directory record Official record
Conditions
Coronary Artery Disease, Coronary Artery Chronic Total Occlusion
Interventions
Crossing of Coronary Artery CTO
Device
Lead sponsor
Asahi Intecc USA Inc
Industry
Eligibility
18 Years and older
Enrollment
163 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
12
States / cities
Phoenix, Arizona • Loveland, Colorado • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 3 Interventional

Peripheral Facilitated Antegrade Steering Technique in Chronic Total Occlusions

NCT01246505
View directory record Official record
Conditions
Chronic Total Occlusion
Interventions
CTO Crossing and Percutaneous transluminal angioplasty
Device
Lead sponsor
BridgePoint Medical
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
10
States / cities
Phoenix, Arizona • Los Angeles, California • Torrance, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2012 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Change in Exercise Capacity as Measured by Peak Oxygen Uptake After CTO PCI

NCT02499666
View directory record Official record
Conditions
Coronary Artery Disease, Angina Pectoris
Interventions
Percutaneous Coronary Intervention, Coronary stent, Clopidogrel
Procedure · Device · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 90 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 6, 2022 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 2 Interventional Results available

Facilitated Antegrade Steering Technique in Chronic Total Occlusions (FAST-CTOs)

NCT00886899
View directory record Official record
Conditions
Coronary Artery Chronic Total Occlusion
Interventions
Recanalization of a coronary chronic total occlusion
Device
Lead sponsor
BridgePoint Medical
Industry
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
16
States / cities
Phoenix, Arizona • La Jolla, California • Sacramento, California + 13 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2012 · Synced Jul 21, 2026, 11:31 AM EDT
Completed Phase 4 Interventional

AngiographiC Evaluation of the Everolimus-Eluting Stent in Chronic Total Occlusions - the ACE-CTO Study

NCT01012869
View directory record Official record
Conditions
Coronary Occlusions
Interventions
everolimus-eluting stent
Device
Lead sponsor
North Texas Veterans Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Jul 21, 2026, 11:31 AM EDT
Terminated No phase listed Observational

Cardiac Cath Lab Staff Radiation Exposure

NCT03959072
View directory record Official record
Conditions
Coronary Artery Disease, Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention
Interventions
Robotic CTO PCI, Conventional (Manual) CTO PCI
Device · Procedure
Lead sponsor
Siemens Healthineers Endovascular Robotics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
74 participants
Timeline
2019 – 2021
U.S. locations
3
States / cities
Kansas City, Missouri • York, Pennsylvania • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 1, 2023 · Synced Jul 21, 2026, 11:31 AM EDT