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Showing 1–24 of 782 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cigarette Smoking Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Source Credibility in Tobacco Regulatory Communications

NCT03339206
View directory record Official record
Conditions
Cigarette Smoking Behavior
Interventions
Constituent message with FDA and quitline, Constituent message without FDA and quitline, Littering message (Control)
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
845 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Switch or Quit R01

NCT06373679
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors
Interventions
Switching to E-Cigarette, Switching using Medication
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months

NCT01639079
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Internet Smoking Cessation Web Site
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 90 Years
Enrollment
146 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 14, 2018 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 4 Interventional

Smoking Study With Behavioral Therapy for Hypertensive Patients

NCT00879177
View directory record Official record
Conditions
Cigarette Smoking, Hypertension
Interventions
Varenicline, behavioral therapy
Drug · Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 9, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Vaping THC From Electronic Cigarettes

NCT02955329
View directory record Official record
Conditions
Marijuana Dependence
Interventions
Nicotine, Cannabis, PAX Loose Leaf Vaporizer
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention

NCT05277831
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Reduction, Smoking, Cigarette, Smoking (Tobacco) Addiction, Smoking Habit
Interventions
Guided Imagery Intervention, Standard Behavioral Control
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
1,209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarette Use in Young Adult Men and Women

NCT03089541
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Use
Interventions
Survey Arm
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years to 29 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD200902: Assessment of Indoor Air Quality for a Heated Tobacco Product With Four Non-Combusted Cigarette Variants in an Environmental Testing Chamber

NCT05363254
View directory record Official record
Conditions
Tobacco Use, Smoking, Tobacco Smoking
Interventions
Marlboro Gold Box, Newport Box, Non-combusted cigarette variant 42001401, Non-combusted cigarette variant 42001399, Non-combusted cigarette variant 40007386, Non-combusted cigarette variant 42001402
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Stockbridge, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

NCT06118502
View directory record Official record
Conditions
Cigarette Smoking, Smoking Behaviors, Treatment
Interventions
Switching to a different medication, Continued use of the same medication, Switching to a harm reduction tobacco product
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
544 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Identify the Usefulness of In-person and Virtual Quit Smoking Programs

NCT05181072
View directory record Official record
Conditions
Cigarette Smoking, Tobacco Use
Interventions
Enhanced in-person peer-motivation smoking cessation, Virtual peer-motivation smoking cessation
Behavioral
Lead sponsor
Morgan State University
Other
Eligibility
21 Years and older
Enrollment
392 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 28, 2024 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation

NCT04525222
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Health Promotion and Education, Smoking Cessation Intervention (Actify app), Smoking Cessation Intervention (Current Standard Care app), Survey Administration
Other · Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Jul 20, 2026, 6:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Experimental Tobacco Marketplace in Regulating Flavored Tobacco Products in Menthol Cigarette Smokers

NCT03897530
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking Cessation Intervention, Functional Assessment, Questionnaire Administration
Behavioral · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhanced Smoking Cessation for University Students

NCT00941395
View directory record Official record
Conditions
Cigarette Smoker, Current Every Day Smoker
Interventions
Survey Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 35 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2017
U.S. locations
2
States / cities
College Station, Texas • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 20, 2018 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting No phase listed Observational

Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

NCT07439471
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Non-Interventional Study
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

NCT02139930
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Smoking
Interventions
Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
1,250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
10
States / cities
Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Aug 14, 2018 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Results available

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

NCT06087328
View directory record Official record
Conditions
Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions
Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

NCT03904186
View directory record Official record
Conditions
Human Immunodeficiency Virus, Smoking Cessation, Smoking, Cigarette, Smoking, Anxiety, Depression, Nicotine Dependence
Interventions
QUIT, Time-Matched Control (TM)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
3
States / cities
Boston, Massachusetts • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Recruiting Phase 2 Interventional

Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

NCT05937854
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension, Dyspnea
Interventions
Tadalafil, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
35 Years to 89 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
5
States / cities
Aurora, Colorado • Decatur, Georgia • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Potential Impact of Menthol Ban in Cigarettes and E-cigarettes

NCT05259566
View directory record Official record
Conditions
Tobacco Smoking
Interventions
menthol ban in cigarettes only, total menthol ban
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 20, 2026, 6:41 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

"Quit Smoking on Your Own" Brief Online Study

NCT02103829
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Brief Intervention #1, Brief Intervention #2, Brief Intervention #3
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years and older
Enrollment
345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2016 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Study of AZD8529 for Smoking Cessation in Female Smokers

NCT02401022
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
AZD8529
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years · Female only
Enrollment
214 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
9
States / cities
Encino, California • La Jolla, California • Los Alamitos, California + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD1603: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From 100s Menthol Cigarette Products

NCT03063047
View directory record Official record
Conditions
Smoking
Interventions
PD21871AA, PD21872AA
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

School Nurse-Delivered Smoking Cessation Intervention

NCT00682474
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Counseling Intervention, Information Intervention
Behavioral
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
13 Years to 18 Years
Enrollment
1,058 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2011 · Synced Jul 20, 2026, 6:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Contingency Management, Quitting Smoking, and ADHD

NCT02266784
View directory record Official record
Conditions
Cigarette Smoking, Smoking Cessation
Interventions
Contingency Management (CM), Transdermal nicotine skin patches (i.e. Habitrol), Supportive Counseling
Behavioral · Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 20, 2026, 6:41 PM EDT