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ClinicalTrials.gov public records Last synced Jul 20, 2026, 6:43 PM EDT

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Showing 1–24 of 38 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Cigarette Smoking-Related Carcinoma Clear all
Completed Phase 1 Interventional Accepts healthy volunteers Results available

mHealth Mood Management Tool (Actify) to Improve Population-Level Smoking Cessation

NCT04525222
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Health Promotion and Education, Smoking Cessation Intervention (Actify app), Smoking Cessation Intervention (Current Standard Care app), Survey Administration
Other · Behavioral
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting No phase listed Observational

Understanding Tobacco and Cannabis Co-Use Practices: Initiation, Escalation, and Maintenance

NCT07439471
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Non-Interventional Study
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial

NCT06145763
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Smoking Cessation Intervention, Survey Administration
Procedure · Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
776 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Behavioral Application for Improving Smoking Cessation Among Smokers

NCT07493252
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone app-based Intervention (Actify! A app), Smartphone app-based Intervention (Actify! B app), Health Promotion and Education, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,812 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

EQQUAL-NM for the Promotion of Smoking Cessation in Sexual and Gender Minority Young Adults in New Mexico

NCT06386432
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone App-delivered Smoking Cessation Intervention, Health Promotion and Education, Biospecimen Collection, Questionnaire Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Jul 20, 2026, 6:43 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of E-cigarette Use on the Body

NCT04972513
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry, Spirometry, Survey Administration, Endothelial function
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pilot Trial of a Game Embedded in a Smartphone App for Smoking Cessation

NCT05227027
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Game Module, Smoke Free smartphone application
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 2, 2024 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Phase 3 Interventional

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

NCT05008848
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smoking Cessation Intervention, Health Promotion and Education, Informational Intervention, Questionnaire Administration
Behavioral · Other
Lead sponsor
Alliance for Clinical Trials in Oncology
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
222
States / cities
Kingman, Arizona • Fort Smith, Arkansas • St. Helena, California + 185 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska Natives, NAITIVE Trial

NCT06697496
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
QuitBot Smoking Cessation Chatbot Program, QuitBot Smoking Cessation Text Messaging Program, Survey Administration, Interview, Carbon Monoxide Measurement
Device · Other · Procedure
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
772 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

NCT06230159
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Non-menthol Cigarette Smoking, Menthol Cigarette Smoking, Synthetic Cooling Agent Cigarette Smoking, Usual Brand Cigarette Smoking, Spirometry, Questionnaire Administration, Nasal Epithelial Lining Fluid
Behavioral · Diagnostic Test · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences

NCT07111234
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Carbon Monoxide Measurement, Nicotine Oral Pouch, Questionnaire Administration, Smoke usual brand cigarette
Procedure · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Not applicable Interventional

Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers

NCT06745154
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Cognitive Assessment, Interview, Nicotine Replacement, Smoking Cessation Intervention, Survey Administration, Tobacco Cessation Counseling
Procedure · Other · Drug + 1 more
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 24 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2024 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Sensory Tests of Cigarettes for Identification of Flavors in Current Daily Smoking Adults

NCT06816459
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Cigarette smell test, Cigarette Taste Test, Study questionnaires
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Filter Ventilation and Ventilation Information on Product Use Behaviors in Cigarette Smokers

NCT04744285
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Cigarette packaging, Data capture, Questionnaire administration
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 69 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Dec 25, 2023 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

NCT07167225
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, E-Cig Use
Interventions
Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment, E-cigarette dependence Scale
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years to 25 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

NCT05121051
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Placebo Administration, Questionnaire Administration
Procedure · Dietary Supplement · Drug + 1 more
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
3
States / cities
Tucson, Arizona • Washington D.C., District of Columbia • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Evaluation of Canakinumab in High-Risk Former-Smokers

NCT06038526
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions
Biospecimen Collection, Bronchoscopy, Canakinumab, Carbon Monoxide Measurement, Survey Administration
Procedure · Biological · Other
Lead sponsor
Peter Shields
Other
Eligibility
40 Years to 73 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Appeal of Nicotine Pouches Versus Cigarettes in the Ohio Appalachia Population

NCT05236894
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Cigarette Smoking, Nicotine Oral Pouch, Questionnaire Administration
Behavioral · Drug · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated May 20, 2024 · Synced Jul 20, 2026, 6:43 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Smoking Cessation Intervention Development for Homeless Youth

NCT06754215
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Focus Group, Interview, Smoking Cessation Intervention, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
14 Years to 24 Years
Enrollment
298 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 6, 2025 · Synced Jul 20, 2026, 6:43 PM EDT
Terminated Not applicable Interventional

Culturally Tailored Educational Video to Promote Lung Cancer Screening in Vulnerable Communities

NCT06010355
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Lung Carcinoma
Interventions
Discussion, Media Intervention, Interview, Test
Procedure · Other
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas

NCT05051345
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Informational Intervention, Media Intervention, Questionnaire Administration, Smoking Cessation Intervention, Survey Administration, Telephone-Based Intervention, Tobacco Cessation Counseling
Other · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
191 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

iCanQuit Smoking Cessation Among Hispanic Adults

NCT06811038
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch, Nicotine Lozenge, Survey Administration, Interview
Device · Drug · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
854 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jul 20, 2026, 6:43 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Broccoli Sprout/Broccoli Seed Extract Supplement in Decreasing Toxicity in Heavy Smokers

NCT03402230
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma
Interventions
Broccoli Sprout/Broccoli Seed Extract Supplement, Laboratory Biomarker Analysis, Questionnaire Administration
Drug · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Jul 20, 2026, 6:43 PM EDT