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ClinicalTrials.gov public records Last synced May 21, 2026, 11:51 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 115 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cigarette Use, Electronic Clear all
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced May 21, 2026, 11:51 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Cigarette Smoking
Interventions
NIDA Standard Research E-cigarette (SREC)
Device
Lead sponsor
University of Southern California
Other
Eligibility
22 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2028
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced May 21, 2026, 11:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol, Beverage without ethanol and E-cigarette liquid without ethanol
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced May 21, 2026, 11:51 PM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Opioid Use Disorder, Cigarette Smoking
Interventions
Telehealth Motivational Counseling, Nicotine Replacement Product, National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
Behavioral · Drug · Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 75 Years
Enrollment
302 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New York, New York • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced May 21, 2026, 11:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced May 21, 2026, 11:51 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Social Media Use Reduction
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 25 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use, E-Cig Use, Cigarette Smoking, Cigarette Use, Electronic
Interventions
E-cigarette e-liquid self-administration
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Myblu variant A, Myblu variant B, Myblu variant C, Myblu variant D, Myblu variant E, Myblu variant F, Myblu variant G, Myblu variant H
Other
Lead sponsor
Fontem US LLC
Industry
Eligibility
21 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Jun 6, 2021 · Synced May 21, 2026, 11:51 PM EDT
Completed Early Phase 1 Interventional
View directory record Official record
Conditions
Healthy, Nicotine Addiction, Electronic Cigarette Use
Interventions
Lower nicotine e-liquid, Higher nicotine eliquid
Drug
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 26, 2024 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions
Control Marketing Strategies, Experimental Marketing Strategies
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
601 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced May 21, 2026, 11:51 PM EDT
Active, not recruiting Phase 4 Interventional
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use
Interventions
Electronic Cigarette, Nicotine Lozenge
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
E-cigarette Flavor, Tobacco Free Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced May 21, 2026, 11:51 PM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Smoking, Cigarette, Nicotine Dependence
Interventions
Nicotine (electronic cigarette), Nicotine (nicotine pouch)
Other
Lead sponsor
Brown University
Other
Eligibility
21 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Preferred Juul pod flavor (5% nicotine), Classic Tobacco Juul pod flavor (5% nicotine), Preferred flavor with HWL, Preferred flavor, 3% nicotine, Preferred flavor, 0% nicotine
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 24 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
Interventions
NJOY ACE e-cigarette
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced May 21, 2026, 11:51 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
E-cigarette Use, Withdrawal
Interventions
Transdermal Nicotine Patch, Placebo Nicotine Patch
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 13, 2025 · Synced May 21, 2026, 11:51 PM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury
Interventions
Not listed
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced May 21, 2026, 11:51 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Vaping, Adolescent, Electronic Cigarette Use, Nicotine, Cannabis
Interventions
Vaping Device Labeling
Other
Lead sponsor
University of Southern California
Other
Eligibility
11 Years to 19 Years
Enrollment
3,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions
E-cigarette
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
461 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Usual Brand Cigarette, Nicorette White Ice Mint nicotine polacrilex gum
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 59 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2021 · Synced May 21, 2026, 11:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
e-cigarettes
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced May 21, 2026, 11:51 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Health Assessments
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced May 21, 2026, 11:51 PM EDT