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Showing 1–24 of 116 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cigarette Use, Electronic Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine and Tobacco Message Framing to Change Smoking Behavior in Diverse Groups of Young Adult Smokers

NCT06644664
View directory record Official record
Conditions
Tobacco-Related Carcinoma
Interventions
Health Education, Interview, Smoking Cessation Intervention, Survey Administration, Text Message-Based Navigation Intervention
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 35 Years
Enrollment
292 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Not applicable Interventional

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

NCT07599462
View directory record Official record
Conditions
Tobacco Products, Cigarettes, Electronic Cigarettes
Interventions
communication
Other
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Selected Constituents in the Exhaled Breath Samples

NCT04143256
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Menthol on ENDS Users' Addiction and Exposure

NCT05338801
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Cigarettes Plus Electronic Cigarettes

NCT04058717
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Evaluation of the Electronic Cigarette Withdrawal Syndrome

NCT06066996
View directory record Official record
Conditions
E-cigarette Use, Withdrawal
Interventions
Transdermal Nicotine Patch, Placebo Nicotine Patch
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

e-Cigarette - DNA Adducts

NCT03284632
View directory record Official record
Conditions
Smoking, Cigarette Smoking, Electronic Cigarettes
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 8, 2022 · Synced Jul 24, 2026, 12:36 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability

NCT03637452
View directory record Official record
Conditions
Tobacco Use
Interventions
Not listed
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 99 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 16, 2020 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Results available

E-Visit for COPD and Smoking Cessation

NCT04155073
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
Interventions
smoking cessation, early COPD detection, electronic visit, Treatment As Usual
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

NCT07598136
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
P2613422, P2611222, P2615522, P2615122, P2615422
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
1,280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
7
States / cities
Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

NCT01964807
View directory record Official record
Conditions
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions
Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 26, 2021 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

NCT02628964
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
e-cigarettes
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years to 35 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2020 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Not applicable Interventional

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

NCT05815199
View directory record Official record
Conditions
Cigarette Smoking
Interventions
E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging
Other · Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Results available

Changes in Biomarkers Associated With Use of Electronic Cigarettes

NCT03084315
View directory record Official record
Conditions
Biomarkers
Interventions
E-Cig Zero Nicotine, E-Cig 24mg Nicotine
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 25, 2021 · Synced Jul 24, 2026, 12:36 AM EDT
Not listed Not applicable Interventional

The Effect of Electronic Cigarette Use on Smoking Behaviors Among Smokers Receiving Outpatient Psychiatric Treatment

NCT04014322
View directory record Official record
Conditions
Tobacco Smoking, Psychiatric Disorders
Interventions
E-cigarette
Other
Lead sponsor
Fordham University
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2023 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Tobacco Use Disparities Among Low-Income Adults

NCT03077737
View directory record Official record
Conditions
Cigarette Smoking, Nicotine Dependence
Interventions
Choose to Change, Enhanced usual care
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

NCT04522973
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Beverage with ethanol and E-cigarette liquid with ethanol, Beverage with ethanol and E-cigarette liquid without ethanol, Beverage without ethanol and E-cigarette liquid with ethanol, Beverage without ethanol and E-cigarette liquid without ethanol
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users

NCT02102100
View directory record Official record
Conditions
Nicotine Dependence
Interventions
nicotine, menthol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jul 24, 2026, 12:36 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Social Media Use on Young Adults' E-Cigarette Use

NCT06142877
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Social Media Use Reduction
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 25 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201203: A Study to Determine Subject Puffing Patterns of a Non-cylindrical, Closed, Electronic Nicotine Delivery System at Three Nicotine Concentrations in an Ambulatory Setting

NCT05118139
View directory record Official record
Conditions
Smoking, Tobacco Use, Electronic Cigarette Use
Interventions
P1211216, P1213416, P1213716, P1213616, P1213816, P1211916, P1210016, P1211217, P1213417, P1211222, P1213422, P1213722, P1213622, P1213822, P1211922, P1210022
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
4
States / cities
Stockbridge, Georgia • Lexington, Kentucky • Hickory, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Vascular Effects of a Single Bout of Electronic Cigarette Use

NCT03209661
View directory record Official record
Conditions
Arterial Stiffness
Interventions
E-cigarette, Nicotine 0%, Menthol Inhalant Product
Drug
Lead sponsor
University of Texas at Austin
Other
Eligibility
20 Years to 30 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures

NCT05205382
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
5% nicotine, 3% nicotine, 0% nicotine
Other
Lead sponsor
Florida International University
Other
Eligibility
21 Years to 35 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Jul 24, 2026, 12:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

NCT02825459
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Jul 24, 2026, 12:36 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

NCT06395415
View directory record Official record
Conditions
Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
Interventions
EQUIP, Standard Care
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 26 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Jul 24, 2026, 12:36 AM EDT