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ClinicalTrials.gov public records Last synced Oct 29, 2026, 3:40 PM EDT

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Showing 1–24 of 504 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine Clear all
Completed Early Phase 1 Interventional

The Effects of Theta Burst Stimulation on the Brain Response to Drug and Alcohol Cues

NCT02939352
View directory record Official record
Conditions
Alcoholism, Cocaine Addiction, Drug Addiction
Interventions
Real continuous Theta Burst Stimulation, Sham continuous Theta Burst Stimulation
Device
Lead sponsor
Medical University of South Carolina
Other
Eligibility
25 Years to 55 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Oct 29, 2026, 3:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Measuring Distress Tolerance With Functional MRI

NCT01038232
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 55 Years
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland • College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 12, 2019 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional Results available

SXC-2023 Cocaine Interaction Study

NCT06343532
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
SXC-2023, SXC-2023 Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 59 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional

A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence

NCT01651364
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
Interventions
Placebo, Cabergoline
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 27, 2012 · Synced Oct 29, 2026, 3:40 PM EDT
Recruiting Not applicable Interventional

Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder

NCT07318480
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder, Opioid Dependence
Interventions
Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
Device · Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 60 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants

NCT04489797
View directory record Official record
Conditions
Infectious Disease
Interventions
Acalabrutinib, Rabeprazole
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Anaheim, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2020 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 2 Interventional

IV Cocaine Abuse: A Laboratory Model - 4

NCT00000215
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Pergolide
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2001
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Not applicable Interventional

RCT of an Integrative Intervention for Non-Treatment-Seeking Meth Users

NCT01926184
View directory record Official record
Conditions
HIV/AIDS, Stimulant Use Disorders
Interventions
Affect Regulation Treatment to Enhance Meth Intervention Success (ARTEMIS), Contingency Management (CM)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Male only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional

Agonist Replacement Therapy for Cocaine Dependence

NCT00697138
View directory record Official record
Conditions
Cocaine Dependence
Interventions
d-Amphetamine; Atomoxetine
Drug
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 50 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional

Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1

NCT00265265
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Atomoxetine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence

NCT00553319
View directory record Official record
Conditions
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Interventions
Placebo, Adderall-XR
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
2
States / cities
Minneapolis, Minnesota • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Not applicable Interventional Results available

The Long-Term Treatment of Drug Addiction and Unemployment

NCT02487745
View directory record Official record
Conditions
Substance Abuse, Intravenous
Interventions
Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
91 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 11, 2022 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Early Phase 1 Interventional Results available

Neurobehavioral Mechanisms of Cocaine Choice

NCT04296006
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Money, Cocaine HCl
Behavioral · Drug
Lead sponsor
Joshua A. Lile, Ph.D.
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 3 Interventional Results available

Smoking-Cessation and Stimulant Treatment (S-CAST)

NCT01077024
View directory record Official record
Conditions
Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
Interventions
Smoking-cessation treatment
Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
538 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
Tucson, Arizona • Rancho Cucamonga, California • Tarzana, California + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Oct 29, 2026, 3:40 PM EDT
Recruiting Early Phase 1 Interventional

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

NCT05011760
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan
Radiation · Drug
Lead sponsor
Rajesh Narendran
Other
Eligibility
18 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Not applicable Interventional

Enhanced and Attendance-based Prize CM in Community Settings

NCT00606853
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Contingency Management
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
443 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Oct 29, 2026, 3:40 PM EDT
Withdrawn Phase 2 Interventional

D-Serine for Cocaine Dependence Pilot

NCT01715051
View directory record Official record
Conditions
Cocaine Dependence
Interventions
D-serine, Cognitive Behavioral Therapy, Placebo
Drug · Behavioral
Lead sponsor
Theresa Winhusen
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 6, 2014 · Synced Oct 29, 2026, 3:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network

NCT02915341
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Not listed
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 18, 2018 · Synced Oct 29, 2026, 3:40 PM EDT
Not listed Phase 2 Interventional

Treating Cocaine Abuse: A Behavioral Approach

NCT01822327
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Contingency Management
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Apr 2, 2013 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 2 Interventional

Mazindol for Cocaine Abuse - 2

NCT00000277
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Mazindol
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
1994 – 1999
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence

NCT00385801
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Risperidone, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2017 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 1 Interventional

Vigabatrin Ph 1 Cocaine Interaction Study

NCT00626834
View directory record Official record
Conditions
Cocaine Addiction
Interventions
Vigabatrin, Matching placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Phase 2 Interventional

High Dose Nimodipine Treatment Adjunct - 1

NCT00000332
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Nimodipine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
22 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2000
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 24, 2017 · Synced Oct 29, 2026, 3:40 PM EDT
Completed Not applicable Interventional

Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives

NCT04927143
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use, Substance Use, Methamphetamine Abuse, Methamphetamine-dependence
Interventions
App-Based Contingency Management, Sham Control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
206 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oconomowoc, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 29, 2026, 3:40 PM EDT