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ClinicalTrials.gov public records Last synced Oct 22, 2026, 7:34 PM EDT

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Showing 1–24 of 154 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Cocaine Use Clear all
Completed Phase 1 Interventional

Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use

NCT01631383
View directory record Official record
Conditions
Cocaine Use
Interventions
l-THP (l-tetrahydropalmatine), Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 50 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Catonsville, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 27, 2019 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Early Phase 1 Interventional Results available

The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders

NCT03953612
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Pregnenolone (PREG), Placebos
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 60 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional

The Effect of Self-Forgiveness on Self-Stigma in Addiction.

NCT03971097
View directory record Official record
Conditions
Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder, Alcohol Withdrawal, Alcohol Abuse, Alcohol Use Disorder, Cocaine Abuse, Cocaine Use Disorder, Cocaine Withdrawal, Benzodiazepine Abuse, Benzodiazepine Dependence, Substance Abuse, Heroin Overdoses, Heroin Withdrawal, Heroin Abuse
Interventions
Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
McKeesport, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 5, 2021 · Synced Oct 22, 2026, 7:34 PM EDT
Active, not recruiting Phase 2 Interventional

Clavulanic Acid for the Treatment of Cocaine Use Disorder

NCT05562349
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Clavulanic Acid Only Product, Placebo
Drug
Lead sponsor
Temple University
Other
Eligibility
18 Years to 70 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

NCT05857852
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Interventions
Low-Intensity Focused Ultrasound, Sham LIFU device
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional

Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting

NCT03662529
View directory record Official record
Conditions
Cocaine Dependence, Cocaine Use Disorder, Opiate Dependence, Opioid-use Disorder, Cannabis Dependence
Interventions
Four-Session Mind Freedom Plan, Treatment as usual therapy
Behavioral
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 7, 2018 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Intranasal Cocaine and Temperature Regulation During Exercise

NCT05809453
View directory record Official record
Conditions
Hyperthermia, Cocaine Use, Exercise
Interventions
Cocaine, Lidocaine
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 50 Years
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 14, 2025 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 1 Interventional Results available

Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder

NCT02537873
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Lorcaserin, Cocaine Intravenous (IV), Placebo comparator
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 59 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 12, 2020 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Reinforcement-Based Treatment for Pregnant Drug Abusers

NCT01177982
View directory record Official record
Conditions
Drug Use Disorders During Pregnancy
Interventions
Usual RBT (t-RBT), Reduced RBT (r-RBT), Abbreviated RBT (a-RBT), Enhanced RBT (e-RBT), Early compliant t-RBT, Early non-compliant t-RBT, Early compliant r-RBT, Early non-compliant r-RBT
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 46 Years · Female only
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional

Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment

NCT01376570
View directory record Official record
Conditions
HIV, Opiate Dependence
Interventions
Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
Behavioral
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
3
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Dec 3, 2020 · Synced Oct 22, 2026, 7:34 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360)

NCT07661823
View directory record Official record
Conditions
Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD, ASD, Alcohol Abuse/Dependence, Alcohol Addiction, Alcohol and Other Drug Use Disorders, Alcohol and Other Substance Use Prevention, Gambling Addiction, Gambling Disorder, Sex Abuse, Sex Behavior, Sex Crimes, Sex Disorder, Sex Disorders, Gender Dysphoria, Adult, Eating Behavior Disorders, Narcotic-Related Disorders, Narcotic Addiction, Narcissism, Psychiatric Disorder, Psychedelic Effects in Healthy Volunteers, Psychedelic Experiences, Psychedelic Drug Dependence, Marijuana Use Disorder, Marijuana Abuse and Dependence, Smoking (Tobacco) Addiction, Smoking Among Youth, Smoking Abstinence, Abstinence, Sex, Opiate Substitution Treatment, Opioid Abuse (Disorder), Opioid Abuse and Addiction, Cocaine Abuse, MDMA ('Ecstasy'), Addiction Disorders, Homeless and Low Incomes People, Refugees, Homelessness, Reliability and Validity, Anger Problems, Child Abuse, Sexual
Interventions
AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
Behavioral
Lead sponsor
Veterans Recovery Network Inc.
Other
Eligibility
17 Years to 99 Years
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2045
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 1 Interventional

Vigabatrin Ph 1 Cocaine Interaction Study

NCT00626834
View directory record Official record
Conditions
Cocaine Addiction
Interventions
Vigabatrin, Matching placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 45 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 1 Interventional Results available

SXC-2023 Cocaine Interaction Study

NCT06343532
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
SXC-2023, SXC-2023 Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 59 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Contingency Management Plus Deep Transcranial Magnetic Stimulation for the Treatment of Cocaine Use Disorder

NCT07490600
View directory record Official record
Conditions
Cocaine Use Disorder (CUD)
Interventions
Contingency Management (CM), Transcranial Magnetic Stimulation (TMS) Sham, Transcranial Magnetic Stimulation (TMS) experimental
Behavioral · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional

Contingency Management for Drug Use: Does Age Matter?

NCT05521854
View directory record Official record
Conditions
Opioid Use Disorder, Methamphetamine Abuse, Cocaine Use Disorder
Interventions
DynamiCare app (app-based contingency management), Sham control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 18, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)

NCT02406066
View directory record Official record
Conditions
Cocaine Use Disorder, Tobacco Use Disorder
Interventions
metyrapone & oxazepam, Placebo
Drug
Lead sponsor
Embera NeuroTherapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
2
States / cities
Long Beach, California • Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Jul 22, 2016 · Synced Oct 22, 2026, 7:34 PM EDT
Recruiting Not applicable Interventional

rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder

NCT05974202
View directory record Official record
Conditions
Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate, Cocaine Use Disorder, Severe
Interventions
Active H7-coil repetitive transcranial magnetic stimulation (rTMS), Sham H7-coil repetitive transcranial magnetic stimulation (rTMS)
Device
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
22 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 2 Interventional

TDCS to Reduce Craving in Cocaine Addiction- Phase 2 Study

NCT04994821
View directory record Official record
Conditions
Cocaine Use Disorder, Cocaine Dependence
Interventions
transcranial direct current stimulator (tDCS), Cognitive Reappraisal
Device · Behavioral
Lead sponsor
Soterix Medical
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Cocaine and Zolmitriptan

NCT05019430
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Cocaine, Placebo oral capsule, Zolmitriptan
Drug
Lead sponsor
William Stoops
Other
Eligibility
18 Years to 55 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence

NCT00385801
View directory record Official record
Conditions
Cocaine Dependence
Interventions
Risperidone, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 28, 2017 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Phase 2 Interventional

Effects of Carvedilol on Cocaine Use in Humans - 11

NCT00000294
View directory record Official record
Conditions
Cocaine-Related Disorders
Interventions
Carvedilol
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
20 Years to 55 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2001
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 22, 2026, 7:34 PM EDT
Completed Not applicable Interventional

Navigation Services to Avoid Rehospitalization (NavSTAR)

NCT02599818
View directory record Official record
Conditions
Opioid-use Disorder, Cocaine Use Disorder, Alcohol Use Disorder
Interventions
NavSTAR
Behavioral
Lead sponsor
Friends Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Oct 22, 2026, 7:34 PM EDT
Completed No phase listed Observational

Cocaine Use and Outcomes of General Anesthesia

NCT02692534
View directory record Official record
Conditions
Anesthesia
Interventions
Urine cocaine negative, Urine cocaine positive
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Oct 22, 2026, 7:34 PM EDT
Recruiting Not applicable Interventional

Cocaine Cue-reactivity Incubation Study

NCT07091877
View directory record Official record
Conditions
Cocaine Use Disorder
Interventions
Cognitive Reappraisal, Control cue-reactivity task
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 65 Years
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Oct 22, 2026, 7:34 PM EDT