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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cognitive Abilities Clear all
Completed Phase 4 Interventional Results available

Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome

NCT01112683
View directory record Official record
Conditions
Down Syndrome
Interventions
Memantine, Placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 32 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 31, 2013 · Synced Sep 17, 2026, 8:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping

NCT04928976
View directory record Official record
Conditions
Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes), Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
Novoic Limited
Industry
Eligibility
50 Years to 85 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Sep 4, 2021 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adolescent Probiotics in Stressed Adolescents

NCT07565883
View directory record Official record
Conditions
Cognitive Ability, General, Immune System Function, Emotions
Interventions
Probiotics, placebo
Dietary Supplement
Lead sponsor
University of Utah
Other
Eligibility
12 Years to 20 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

NCT03574207
View directory record Official record
Conditions
Mild Cognitive Impairment, Memory Loss
Interventions
Transcranial magnetic stimulation
Device
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - FUTURE Extension

NCT04951284
View directory record Official record
Conditions
Alzheimer Disease, Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer's Disease (Incl Subtypes), Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
Novoic Limited
Industry
Eligibility
50 Years to 85 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Multidimensional Assessment and Intervention for Elder Self-Neglect

NCT00901706
View directory record Official record
Conditions
Self-Neglect, Cognitive Ability, General, Geriatric Disorder
Interventions
Comprehensive Geriatric Assessment and APS Usual Care, APS usual care
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 17, 2013 · Synced Sep 17, 2026, 8:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Interventions in Mathematics and Cognitive Skills

NCT05201534
View directory record Official record
Conditions
Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities, Learning Disabled, Learning Curve, Mathematics Disorder, Dyscalculia, Dyscalculia, Primary, Dyscalculia, Acquired, Specific Learning Disorder, With Impairment in Mathematics, Individuality, Behavior, Child, Behavior and Behavior Mechanisms, Behavior, Decision Making, Neuronal Plasticity, Cognition, Cognition Disorder, Cognitive Dysfunction, Cognitive Change, Cognitive Impairment, Mild, Cognitive Developmental Delay, Cognitive Orientation, Cognitive Delay, Mild, Cognitive Deficits, Mild, Cognitive Abnormality, Neuroscience
Interventions
Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
Other
Lead sponsor
Stanford University
Other
Eligibility
6 Years to 12 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Phase 2 Interventional Results available

Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis

NCT00841321
View directory record Official record
Conditions
Multiple Sclerosis, Cognitive Ability, General
Interventions
Ginkgo biloba, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
2
States / cities
Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 5, 2014 · Synced Sep 17, 2026, 8:56 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Neural and Cognitive Consequences of COVID-19 Survival

NCT06208943
View directory record Official record
Conditions
COVID Long-Haul, COVID-19, COVID-19 Pandemic, Brain Fog, Memory Deficits, Concentration Ability Impaired, Fatigue
Interventions
cross-sectional MRI and EEG assessments (NO INTERVENTION)
Other
Lead sponsor
San Francisco Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 70 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 11, 2024 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

INSIGHT, A Comprehensive, Multidisciplinary Brain Training System

NCT02780739
View directory record Official record
Conditions
Cognitive Ability, General
Interventions
Cognitive Training - 48 sessions, Fitness, Active Control, active tDCS, sham tDCS, Cognitive Training - 20 sessions
Behavioral · Device
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 44 Years
Enrollment
521 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated May 22, 2016 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study

NCT02726906
View directory record Official record
Conditions
Aging, Cognitive Ability, General
Interventions
Moderate-aerobic walking, Positron Emission Tomography (PET) scan, Healthy living education, Physical activity monitor
Behavioral · Radiation · Device
Lead sponsor
University of Southern California
Other
Eligibility
55 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High-Intensity Exercise in Older Adults

NCT06199661
View directory record Official record
Conditions
Functional Fitness, Cognitive Abilities
Interventions
APEX
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
50 Years to 80 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Memory and Cognitive Performance Study

NCT04025255
View directory record Official record
Conditions
Cognitive Function, Memory, Brain Health
Interventions
Braini, Placebo
Dietary Supplement
Lead sponsor
Vita Naturel, LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Asheville, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 17, 2026, 8:56 AM EDT
Not listed Not applicable Interventional

Modafinil in Treating Fatigue in Patients With Cancer

NCT00112515
View directory record Official record
Conditions
Cognitive/Functional Effects, Depression, Fatigue, Unspecified Adult Solid Tumor, Protocol Specific
Interventions
modafinil, cognitive assessment, psychosocial assessment and care, quality-of-life assessment
Drug · Procedure
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Sep 17, 2026, 8:56 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effect of Preksha Meditation on Cognitive Abilities and Pulmonary Function in Students

NCT03779269
View directory record Official record
Conditions
Inattention and Memory, Affect
Interventions
meditation
Other
Lead sponsor
Orlando Regional Medical Center
Other
Eligibility
18 Years to 24 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
2
States / cities
Miami Beach, Florida • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 20, 2022 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intervention Comparative Effectiveness for Adult Cognitive Training

NCT03141281
View directory record Official record
Conditions
Cognitive Aging
Interventions
BrainHQ, Rise of Nations, IADL Training, Active Control
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
65 Years and older
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jun 6, 2021 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Phase 2 Interventional Results available

Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid

NCT00742417
View directory record Official record
Conditions
Alzheimer's Disease
Interventions
Albutein 5%, Control
Biological · Other
Lead sponsor
Instituto Grifols, S.A.
Industry
Eligibility
55 Years to 85 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Whiting, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 13, 2016 · Synced Sep 17, 2026, 8:56 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Childhood Anesthesia and Cognitive Function

NCT01359215
View directory record Official record
Conditions
Cognitive Deficits, Cognitive Ability, General
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
6 Years to 12 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
Davis, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2013 · Synced Sep 17, 2026, 8:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Unconscious Mind Training

NCT07597603
View directory record Official record
Conditions
Memory Encoding, Memory, Behavior Change Interventions, Habits
Interventions
Intervention H22
Behavioral
Lead sponsor
Dream Video LLC
Other
Eligibility
10 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2028
U.S. locations
1
States / cities
Naples, Florida
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Not applicable Interventional

Older Adults, Methadone, and Cognitive Function

NCT07153029
View directory record Official record
Conditions
Opioid Use Disorder, Cognitive Ability General
Interventions
Smartphone based cognitive tasks
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
55 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition

NCT07407426
View directory record Official record
Conditions
Cognitive Abilities, Performance, Stress, Cognitive Performance
Interventions
EEG-guided binaural beat audio, Non-binaural audio intervention
Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 17, 2026, 8:56 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Galantamine Effects on Cognitive Function in Marijuana Users

NCT00969696
View directory record Official record
Conditions
Memory
Interventions
Placebo, Galantamine
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 24, 2012 · Synced Sep 17, 2026, 8:56 AM EDT
Withdrawn Not applicable Interventional

Improving Caregivers' Ability to Manage Life Stress

NCT05539352
View directory record Official record
Conditions
Suicidal Ideation
Interventions
Problem Solving Therapy (PST) plus EUC
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Sep 17, 2026, 8:56 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Cognitive Control Abilities Using Mobile Technology in a Senior Living Community

NCT04905849
View directory record Official record
Conditions
Aging, Cognitive Change
Interventions
Adaptive Cognitive Control Trainer (ACCT), Active Control App
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
50 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Sep 17, 2026, 8:56 AM EDT