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Showing 1–24 of 211 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Cognitive Performance Clear all
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults

NCT03512028
View directory record Official record
Conditions
Healthy, Young Adults
Interventions
RLIC, Sham conditioning, Muscle strength training, Driving training, Balance training
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 40 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 4, 2020 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dose-Response Effect of Phosphatidylserine on eSport Performance

NCT07533032
View directory record Official record
Conditions
Cognitive Function, Gaming Performance
Interventions
Placebo, Phosphatidylserine (100 mg), Phosphatidylserine (200 mg)
Dietary Supplement
Lead sponsor
Lindenwood University
Other
Eligibility
18 Years to 40 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Saint Charles, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Coffeeberry on Mood, Motivation and Cognitive Performance

NCT04974606
View directory record Official record
Conditions
Fatigue, Mental, Alertness, Mood, Motivation, Cognitive Performance
Interventions
Cherry-flavored still beverage, Placebo cherry-flavored still beverage
Dietary Supplement · Other
Lead sponsor
PepsiCo Global R&D
Industry
Eligibility
17 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 22, 2021 · Synced Jul 21, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional

Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)

NCT07385105
View directory record Official record
Conditions
Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
Interventions
Cognitive behavioral Therapy for insomnia (CBT-I)
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study of Sabroxy™ (Oroxylum Indicum Extract) for Improving Cognitive Function in Adults With Mild Memory Concerns

NCT07189754
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Cognitive Dysfunction, Cognitive Disorder, Memory Problems
Interventions
Sabroxy™ (Oroxylum indicum extract), Placebo
Dietary Supplement · Other
Lead sponsor
SF Research Institute, Inc.
Network
Eligibility
60 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Jul 21, 2026, 5:06 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Postural Control Under Different Cognitive Loads in Adult Survivors of Acute Lymphoblastic Leukemia and Age-Matched Healthy Individuals

NCT03581045
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia
Interventions
Not listed
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
18 Years to 39 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 18, 2022 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuromuscular Cognitive Training

NCT05459363
View directory record Official record
Conditions
Injury;Sports
Interventions
I-THINC
Other
Lead sponsor
Ke'La H Porter
Other
Eligibility
18 Years to 30 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating the Potentials of Biodynamic Lighting for Home Office Workers

NCT05481424
View directory record Official record
Conditions
Cognitive Performance, Sleep, Alertness
Interventions
Biodynamic, Active Placebo
Other
Lead sponsor
Arizona State University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Crossover Study to Evaluate the Effect of Lemborexant Versus Placebo and Zolpidem on Postural Stability, Auditory Awakening Threshold, and Cognitive Performance in Healthy Subjects 55 Years and Older

NCT03008447
View directory record Official record
Conditions
Healthy Subjects
Interventions
LEM5, LEM10, ZOL, PBO
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
55 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
4
States / cities
Atlanta, Georgia • New York, New York • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Home Operations Utilizing Stimulation

NCT04484285
View directory record Official record
Conditions
Cognitive Performance
Interventions
Transcutaneous Vagal Nerve Stimulation (tVNS)
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 85 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 19, 2025 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Red Spinach Extract Supplementation on Isometric Strength, Resistance Exercise and Cognitive Performance

NCT04292106
View directory record Official record
Conditions
Sports
Interventions
Red Spinach Extract (RSE), Placebo
Dietary Supplement
Lead sponsor
Lipscomb University
Other
Eligibility
18 Years to 34 Years · Male only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effect of Huperzine A on Cognitive Function and Perception of Effort During Exercise

NCT03445104
View directory record Official record
Conditions
Cognitive Enhancement During Exercise
Interventions
Huperzine A, Placebo
Other
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 30, 2018 · Synced Jul 21, 2026, 5:06 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance

NCT04908358
View directory record Official record
Conditions
Aging
Interventions
Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions, Sham transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years to 85 Years
Enrollment
126 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Sleep Disordered Breathing and Its Impact on Neuro-cognitive Performance and Quality of Life in Parkinson Disease

NCT02034357
View directory record Official record
Conditions
Parkinson's Disease, Sleep Disordered Breathing, Sleep Obstructive Apnea
Interventions
Neurocognitive function, Sleep evaluations
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI

NCT01234454
View directory record Official record
Conditions
Schizophrenia
Interventions
Risperidone, Olanzapine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2007
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced Jul 21, 2026, 5:06 PM EDT
Terminated No phase listed Observational

Characterizing Fatigue Experienced by Registered Nurses

NCT03789188
View directory record Official record
Conditions
Fatigue
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
18 Years and older
Enrollment
313 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 5, 2021 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Acute Pain on Cognitive Performance in Young Adults

NCT05625776
View directory record Official record
Conditions
Pain, Acute, Cognition
Interventions
pain delivery with capsaicin and heat, distractor delivery with sensory TENS
Procedure
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 35 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Dec 10, 2023 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Effects of Cannabidiol on the Driving Ability of Healthy Adults

NCT04590495
View directory record Official record
Conditions
Driving Performance, Cognitive Impairment, Sedation Complication, Mood
Interventions
300 mg Cannabidiol (CBD) oil, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Jul 21, 2026, 5:06 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults

NCT07453537
View directory record Official record
Conditions
Stress Response, Mental Stress, Multitasking Behavior and Multitasking Ability, Physiological Stress, Cognitive Symptoms, Motor Activity
Interventions
Cranberry juice, Placebo juice
Other
Lead sponsor
University of Florida
Other
Eligibility
30 Years to 55 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation

NCT06782360
View directory record Official record
Conditions
Healthy, Cognitive Change, Effects of External Neurostimulation on Cognition
Interventions
Active Neurostimulation, Sham Stimulation
Device
Lead sponsor
OpenBCI
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increased Protein at Breakfast for Weight Management in Overweight Adolescents

NCT03146442
View directory record Official record
Conditions
Obesity, Adolescent
Interventions
Breakfast
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
13 Years to 21 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults

NCT06995560
View directory record Official record
Conditions
Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition, Psychomotor Performance, Neurophysiology
Interventions
Active Transcranial Electrical Stimulation, Sham Transcranial Electrical Stimulation
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
25 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 21, 2026, 5:06 PM EDT
Completed Not applicable Interventional

Adapting Daily Activity Performance Through Strategy Training

NCT01934621
View directory record Official record
Conditions
Strategy Training, Attention Control
Interventions
Strategy Training, Attention Control
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Jul 21, 2026, 5:06 PM EDT
Not listed Not applicable Interventional

A Novel Virtual Reality Task in Parkinson's Disease

NCT05859308
View directory record Official record
Conditions
Parkinson Disease
Interventions
Virtual Reality Pixel Plucker, Rock Steady Boxing
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 21, 2026, 5:06 PM EDT