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Showing 1–24 of 61 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Coma Clear all
Suspended Phase 2 Interventional

Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury

NCT00761228
View directory record Official record
Conditions
Brain Injury
Interventions
Apomorphine, Placebo
Drug
Lead sponsor
NeuroHealing Pharmaceuticals Inc.
Industry
Eligibility
18 Years to 50 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 30, 2017 · Synced Jul 21, 2026, 4:53 AM EDT
Not yet recruiting Not applicable Interventional

The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury

NCT07331324
View directory record Official record
Conditions
Caregiver Distress, Emotional Distress, Caregivers, Resilience, Coma, Brain Injury
Interventions
Coma Family Program 1, Coma Family Program 2
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
3
States / cities
Baltimore, Maryland • Boston, Massachusetts • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated Not applicable Interventional

Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors

NCT01810640
View directory record Official record
Conditions
Brain Death, Liver Disease
Interventions
Percutaneous Liver Biopsy
Procedure
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
Not listed
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
New Providence, New Jersey • Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Does Venous pCO2 Increase by 20 mmHg or More During Apnea Challenge Test?

NCT02503813
View directory record Official record
Conditions
Brain Death
Interventions
venous blood gas
Procedure
Lead sponsor
MemorialCare Health System
Other
Eligibility
1 Week and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2022 · Synced Jul 21, 2026, 4:53 AM EDT
Not yet recruiting Phase 3 Interventional

Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest

NCT03176186
View directory record Official record
Conditions
Post-Cardiac Arrest Syndrome
Interventions
Xenon
Combination Product
Lead sponsor
Invero Pharma, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
1,436 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
8
States / cities
Hartford, Connecticut • Gainesville, Florida • Gulfport, Mississippi + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

The Efficacy of Familiar Voice Stimulation During Coma Recovery

NCT00557076
View directory record Official record
Conditions
Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
Interventions
Familiar Auditory Sensory Training, Sham Auditory Sensory Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Chicago, Illinois • Hines, Illinois • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 5, 2019 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

fNIRS for Disorders of Consciousness

NCT07485361
View directory record Official record
Conditions
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions
Functional Near-Infrared Spectroscopy Monitoring
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting No phase listed Observational

Recovery Trajectory for Coma and Disorders of Consciousness

NCT07614074
View directory record Official record
Conditions
Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Meningitis/Encephalitis, Status Epilepticus
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2033
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Phase 2 Interventional

Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants

NCT01624311
View directory record Official record
Conditions
Urea Cycle Disorders, Organic Acidemias
Interventions
Therapeutic Hypothermia, Standard of Care Therapy
Other
Lead sponsor
Uta Lichter-Konecki
Other
Eligibility
1 Day to 30 Days
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
3
States / cities
Washington D.C., District of Columbia • New York, New York • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 31, 2015 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting No phase listed Observational

Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest

NCT06511999
View directory record Official record
Conditions
Cardiac Arrest
Interventions
Continuous SjO2 monitoring with a PediaSat Oximetry Catheter, Intermittent SjO2 monitoring with a PediaSat Oximetry Catheter
Device · Diagnostic Test
Lead sponsor
Byron Drumheller
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Cervical Spine Clearance in Obtunded Trauma Patients

NCT00573014
View directory record Official record
Conditions
Coma, Wounds and Injuries
Interventions
Cervical Spine Clearance
Other
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
Not listed
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational Results available

Validity and Feasibility of the CRSR-FAST

NCT03549572
View directory record Official record
Conditions
Disorder of Consciousness, Traumatic Brain Injury
Interventions
Coma Recovery Scale-Revised
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Deceased Organ Donor Interventions to Protect Kidney Graft Function

NCT02525510
View directory record Official record
Conditions
Brain Death, Organ Donation, Organ Transplant Failure or Rejection, Delayed Graft Function
Interventions
Pump Eligible - Normothermia - Pump Both Kidneys, Pump Eligible - Hypothermia and Pump Right Kidney, Pump Eligible - Hypothermia and Pump Left Kidney, Not Pump Eligible - Normothermia, Not Pump Eligible - Hypothermia
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
1,427 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
7
States / cities
Phoenix, Arizona • San Francisco, California • Denver, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2022 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated Not applicable Interventional Results available

A Pilot Study of NSICU Assessment of Seizure Prophylaxis With Lacosamide

NCT01110187
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
lacosamide, Fosphenytoin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
3
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 27, 2014 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated No phase listed Observational

Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure

NCT01582087
View directory record Official record
Conditions
Acute and Chronic Hepatic Failure With Developing Coma
Interventions
Not listed
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Study of Brain Cools Device in Patients Resuscitated From Cardiac Arrest

NCT03889340
View directory record Official record
Conditions
Cardiac Arrest With Successful Resuscitation
Interventions
IQool
Device
Lead sponsor
Adam Frisch
Other
Eligibility
18 Years and older
Enrollment
38 participants
Timeline
2019 – 2021
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2021 · Synced Jul 21, 2026, 4:53 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination

NCT03743805
View directory record Official record
Conditions
Brain Death, Anoxic Brain Injury, Cardiac Arrest, Sedative Intoxication, Narcotic Intoxication
Interventions
Flumazenil, Naloxone
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Promoting Recovery After Brain Injury Using Focused Ultrasound

NCT07277309
View directory record Official record
Conditions
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Interventions
Low-intensity focused ultrasound
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy.

NCT01283152
View directory record Official record
Conditions
Hepatic Encephalopathy, Cirrhosis, Portosystemic Encephalopathy, PSE
Interventions
Polyethylene glycol 3350-electrolyte solution (GoLYTELY®), Lactulose
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Organ Donor Tissue Oxygen Saturation as a Predictor of Number of Organs to Transplant Per Donor

NCT01819116
View directory record Official record
Conditions
Brain Death
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
15 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 26, 2016 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury

NCT07560631
View directory record Official record
Conditions
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
Interventions
SeeMe Multimodal Auditory Command Protocol
Diagnostic Test
Lead sponsor
Stony Brook University
Other
Eligibility
22 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Withdrawn Not applicable Interventional

Hepatic Encephalopathy: Lactulose or Polyethylene Glycol (H.E.L.P.)

NCT01923376
View directory record Official record
Conditions
Hepatic Encephalopathy, HE, Cirrhosis, Altered Mental Status, AMS
Interventions
Lactulose, Polyethylene Glycol 3350
Drug
Lead sponsor
New York Presbyterian Brooklyn Methodist Hospital
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated May 11, 2015 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Prognostication of Recovery in Early Disorders of Consciousness After COVID-19

NCT04476589
View directory record Official record
Conditions
Covid19, Coma, Consciousness Disorder
Interventions
Functional MRI
Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
12 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 3, 2023 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injuries

NCT05761925
View directory record Official record
Conditions
Coma, Emotional Distress
Interventions
COMA-F
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Jul 21, 2026, 4:53 AM EDT