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ClinicalTrials.gov public records Last synced May 22, 2026, 12:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Complications, Arthroplasty Clear all
Completed Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Static Spacer, Articulating Spacer
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced May 22, 2026, 12:05 AM EDT
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Lower Limb Deformity, Post-traumatic Deformity, Complications, Arthroplasty
Interventions
Vanguard XP Bicruciate Knee System, Vanguard CR Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
2
States / cities
Chicago, Illinois • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced May 22, 2026, 12:05 AM EDT
Not yet recruiting Not applicable Interventional
View directory record Official record
Conditions
Patient Readmission, Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip, Heart Failure, Pulmonary Disease, Chronic Obstructive, Renal Insufficiency, Body Mass Index, Alcoholism
Interventions
Nurse Navigator Program
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced May 22, 2026, 12:05 AM EDT
Withdrawn Phase 2 Interventional
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Brivoligide Injection 660 mg/6 mL, Placebo 6 mL
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
2
States / cities
Sheffield, Alabama • Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Knee Osteoarthritis, Arthroplasty Complications
Interventions
Treadmill-based perturbation training, Education Control
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Sleep Disturbance, Shoulder Arthritis, Arthroplasty Complications, Perioperative/Postoperative Complications
Interventions
Zolpidem
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 26, 2020 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Total Knee Arthroplasty, Total Hip Arthroplasty Revision, Total Knee Arthroplasty Revision
Interventions
Avance Solo Negative Pressure Wound Therapy
Device
Lead sponsor
Molnlycke Health Care AB
Industry
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
8
States / cities
Washington D.C., District of Columbia • Indianapolis, Indiana • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Phase 4 Interventional
View directory record Official record
Conditions
Acute Postoperative Pain, Surgery
Interventions
continuous peripheral nerve block with OnQ pump, single injection nerve block
Device · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced May 22, 2026, 12:05 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Knee Osteoarthritis, Blood Loss, Pain, Postoperative
Interventions
Tranexamic Acid Pill, Placebo
Drug
Lead sponsor
Campbell Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 5, 2024 · Synced May 22, 2026, 12:05 AM EDT
Completed No phase listed Observational Accepts healthy volunteers
View directory record Official record
Conditions
Surgical Site Infection
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
234 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Phase 3 Interventional
View directory record Official record
Conditions
Post Operative Pain, Total Hip Arthroplasty
Interventions
Methadone
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 75 Years
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 7, 2020 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Postoperative Pain
Interventions
Tranexamic acid
Drug
Lead sponsor
Matthew Grosso, MD
Other
Eligibility
18 Years to 89 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Osteoarthritis, Hip, Joint Deformities, Acquired, Hip Dislocation, Congenital, Osteonecrosis, Arthritis, Rheumatoid
Interventions
Aquamantys, standard electrocautery (Bovie)
Device
Lead sponsor
Joint Implant Surgeons, Inc.
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
New Albany, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 23, 2012 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Knee Osteoarthritis, Pain, Postoperative
Interventions
Multimodal analgesia including pregabalin, Multimodal analgesia not including pregabalin
Other
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2024 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Total Knee Replacement, Total Knee Arthroplasty, Pain, Postoperative Pain, Orthopedic Disorder
Interventions
SPRINT Beta System
Device
Lead sponsor
SPR Therapeutics, Inc.
Industry
Eligibility
21 Years to 90 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
5
States / cities
La Jolla, California • Durham, North Carolina • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated May 11, 2021 · Synced May 22, 2026, 12:05 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Surgical Site Infection, Surgical Wound Infection
Interventions
Floraseal
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2019 · Synced May 22, 2026, 12:05 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Pain, Postoperative
Interventions
Adductor Canal Block, Adductor Canal Block
Procedure · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced May 22, 2026, 12:05 AM EDT
Active, not recruiting No phase listed Observational
View directory record Official record
Conditions
Rheumatoid Arthritis, Ankylosing Spondylitis
Interventions
Not listed
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
20 Years to 100 Years
Enrollment
521,292 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2029
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 2 Interventional
View directory record Official record
Conditions
Postsurgical Pain
Interventions
Placebo Injection, AYX1 Injection 110 mg, AYX1 Injection 330 mg
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
7
States / cities
Sheffield, Alabama • Phoenix, Arizona • Boynton Beach, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2015 · Synced May 22, 2026, 12:05 AM EDT
Recruiting Early Phase 1 Interventional
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Active Comparator, Placebo Comparator
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Dec 28, 2025 · Synced May 22, 2026, 12:05 AM EDT
Completed Phase 4 Interventional
View directory record Official record
Conditions
Prosthesis-Related Infections, Arthroplasty
Interventions
Betadine Lavage, Saline Lavage
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
505 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2019
U.S. locations
2
States / cities
Chicago, Illinois • Winfield, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced May 22, 2026, 12:05 AM EDT
Not yet recruiting Phase 2 Interventional
View directory record Official record
Conditions
Total Hip Arthroplasty
Interventions
intravenous administration of oxytocin, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced May 22, 2026, 12:05 AM EDT
Not listed Phase 4 Interventional
View directory record Official record
Conditions
Pain, Postoperative, Satisfaction
Interventions
Ropivacaine
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced May 22, 2026, 12:05 AM EDT