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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Deafness Clear all
Completed Phase 1Phase 2 Interventional Results available

Safety, Tolerability and Efficacy for CGF166 in Patients With Unilateral or Bilateral Severe-to-profound Hearing Loss

NCT02132130
View directory record Official record
Conditions
Unilateral Severe to Profound Hearing Loss OR Bilateral Severe to Profound Hearing Loss
Interventions
CGF166
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
4
States / cities
Kansas City, Kansas • Baltimore, Maryland • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Listening Effort in Cochlear Implant Users

NCT06516575
View directory record Official record
Conditions
Auditory Perception; Abnormal, Hearing Loss, Sensorineural, Hearing Loss
Interventions
sentence manipulations
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Wide-Bandwidth Open Canal Hearing Aid For Better Multitalker Speech Understanding

NCT00582946
View directory record Official record
Conditions
Hearing Impairment
Interventions
Hearing Aid
Device
Lead sponsor
EarLens Corporation
Industry
Eligibility
21 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Sep 12, 2026, 2:58 PM EDT
Terminated No phase listed Observational

Genetic Analysis of Human Hereditary Hearing Impairment

NCT00001606
View directory record Official record
Conditions
Partial Hearing Loss
Interventions
Not listed
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
Not listed
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2019 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Not applicable Interventional

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

NCT06662058
View directory record Official record
Conditions
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck, Head and Neck Carcinoma of Unknown Primary, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma, Metastatic Nasopharyngeal Squamous Cell Carcinoma, Metastatic Oral Cavity Squamous Cell Carcinoma, Metastatic Oropharyngeal Squamous Cell Carcinoma, Metastatic Paranasal Sinus Squamous Cell Carcinoma, Nasopharyngeal Squamous Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma, Paranasal Sinus Squamous Cell Carcinoma, Recurrent Cutaneous Squamous Cell Carcinoma of the Head and Neck, Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Nasopharyngeal Squamous Cell Carcinoma, Recurrent Oral Cavity Squamous Cell Carcinoma, Recurrent Oropharyngeal Squamous Cell Carcinoma, Recurrent Paranasal Sinus Squamous Cell Carcinoma, Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8, Stage IV Hypopharyngeal Carcinoma AJCC v8, Stage IV Laryngeal Cancer AJCC v8, Stage IV Lip and Oral Cavity Cancer AJCC v8, Stage IV Nasopharyngeal Carcinoma AJCC v8, Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8, Stage IV Sinonasal Cancer AJCC v8
Interventions
Audiometric Test, Interview
Procedure · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 12, 2026, 2:58 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Predicting Success With Hearing Aids

NCT00371449
View directory record Official record
Conditions
Hearing Loss, Presbycusis
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 85 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Mountain Home, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Sep 12, 2026, 2:58 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Refining Information Technology Support for Genetics in Medicine

NCT01225978
View directory record Official record
Conditions
Hypertrophic Cardiomyopathy, Hearing Loss, Cancer
Interventions
GeneInsight Clinic (GIC)
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
8
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 23, 2014 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Not applicable Interventional

Word Learning in Deaf Children Using Eye-tracking and Behavioral Measures

NCT05993832
View directory record Official record
Conditions
Deafness
Interventions
input cue
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Months to 60 Months
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Sep 12, 2026, 2:58 PM EDT
Not listed No phase listed Observational

SoundBite Hearing System Long Term Multi Site Patient Use Study

NCT01445977
View directory record Official record
Conditions
Single Sided Deafness, Conductive Hearing Loss
Interventions
Not listed
Lead sponsor
Sonitus Medical Inc
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
13
States / cities
Phoenix, Arizona • La Jolla, California • Newport Beach, California + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Not applicable Interventional Results available

Remote Microphone (RM) - A Comparative Study

NCT04147611
View directory record Official record
Conditions
Hearing Loss, Conductive
Interventions
BAHA, Wireless Audio Streaming Accessory, Digital Adaptive RM System, Hearing Aid
Device
Lead sponsor
University of Miami
Other
Eligibility
5 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Sep 12, 2026, 2:58 PM EDT
Terminated Phase 3 Interventional

Autoimmunity in Inner Ear Disease

NCT00000361
View directory record Official record
Conditions
Hearing Loss, Sensorineural
Interventions
Corticosteroids, Methotrexate
Drug
Lead sponsor
National Institute on Deafness and Other Communication Disorders (NIDCD)
NIH
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
9
States / cities
Los Angeles, California • San Diego, California • Iowa City, Iowa + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2006 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Not applicable Interventional Results available

Design Improvements With SONNET 3

NCT06597747
View directory record Official record
Conditions
Hearing Loss, Sensorineural
Interventions
Audio processor
Device
Lead sponsor
Med-El Corporation
Industry
Eligibility
7 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Encoding Temporal Fine Structure for Cochlear Implants

NCT04708717
View directory record Official record
Conditions
Hearing Loss, Cochlear Implants
Interventions
Stimulation Rate, Electrode Location
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Clear Speech on Listening Effort and Memory in Sentence Processing

NCT06053190
View directory record Official record
Conditions
Speech, Memory, Delayed, Sensorineural Hearing Loss
Interventions
Sentence stimulus, Speaking style
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 90 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Sep 12, 2026, 2:58 PM EDT
Withdrawn Not applicable Interventional

Mindfulness Intervention and Symptom Variability in Hearing

NCT04281225
View directory record Official record
Conditions
Hearing Loss
Interventions
Attention to Variability (ATV), Placebo
Behavioral · Other
Lead sponsor
Harvard University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2022 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Phase 2 Interventional Results available

SPI-1005 for the Treatment of Patients With Meniere's Disease

NCT03325790
View directory record Official record
Conditions
Meniere's Disease
Interventions
200mg SPI-1005 BID, 400mg SPI-1005 BID, Placebo
Drug · Other
Lead sponsor
Sound Pharmaceuticals, Incorporated
Industry
Eligibility
18 Years to 75 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
13
States / cities
Fresno, California • San Diego, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 17, 2023 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hearing Aid Noise Reduction in Pediatric Users Pilot Study (Oticon Pilot Study)

NCT04469946
View directory record Official record
Conditions
Hearing Impairment, Sensorineural Hearing Loss, Bilateral
Interventions
Oticon OpenSound Navigator speech enhancement algorithm
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Years to 12 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Outcomes in Children With Pre-operative Residual Hearing

NCT03379870
View directory record Official record
Conditions
High Frequency Sensorineural Hearing Impairment, Hearing Disorders in Children
Interventions
Electric Acoustic Speech Processor: Electric-acoustic stimulation fitting, Electric Acoustic Speech Processor: Full-electric stimulation fitting
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
60 Months to 215 Months
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Phase 3 Interventional

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

NCT06451757
View directory record Official record
Conditions
Mitochondrial Diseases, Maternally Inherited Diabetes and Deafness (MIDD), Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS), Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation
Interventions
Sonlicromanol, Placebo
Drug
Lead sponsor
Khondrion BV
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
3
States / cities
Boston, Massachusetts • Cleveland, Ohio • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Sep 12, 2026, 2:58 PM EDT
Completed Phase 1 Interventional

OTO-104 for Meniere's Disease

NCT01084525
View directory record Official record
Conditions
Meniere's Disease
Interventions
OTO-104 (steroid) 3 mg, Placebo, OTO-104 (steroid) 12 mg
Drug
Lead sponsor
Otonomy, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Colorado Springs, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2011 · Synced Sep 12, 2026, 2:58 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Low-Level Laser Stimulation on Hearing Thresholds

NCT01820416
View directory record Official record
Conditions
Hearing Loss
Interventions
Low-level Laser Therapy, Placebo Comparator: Disabled Laser
Radiation · Other
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Sep 12, 2026, 2:58 PM EDT
Terminated Not applicable Interventional

Prospective Study of Round Window Versus Cochleostomy Approach to CI Surgery

NCT02466763
View directory record Official record
Conditions
Deafness
Interventions
Cochlear implant surgery
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Phase 1Phase 2 Interventional

Open-label Study of SKY-GJB2 in Pediatric Subjects With GJB2-mediated Hearing Loss

NCT07627971
View directory record Official record
Conditions
GJB2-mediated Hearing Loss, GJB2 Gene Mutation, DFNB1A
Interventions
SKY-GJB2
Combination Product
Lead sponsor
Skylark Bio Inc.
Industry
Eligibility
9 Months to 7 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
4
States / cities
Bethesda, Maryland • Boston, Massachusetts • Oklahoma City, Oklahoma + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Sep 12, 2026, 2:58 PM EDT
Recruiting Phase 1Phase 2 Interventional

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

NCT07407582
View directory record Official record
Conditions
Solid Tumor Malignancies, Testicular Cancer, Head and Neck Cancer, Thoracic Cancer
Interventions
Pedmark® STS
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Sep 12, 2026, 2:58 PM EDT