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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Delayed Sleep Phase Clear all
Terminated No phase listed Observational Accepts healthy volunteers

Biomarkers for Circadian Timing in Healthy Adults

NCT03956745
View directory record Official record
Conditions
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS), Advanced Sleep Phase Syndrome, Advanced Sleep Phase, Delayed Sleep Phase, Delayed Sleep Phase Syndrome, Non-24 Hour Sleep-Wake Disorder, Irregular Sleep-Wake Syndrome, Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Delayed Phase Sleep Syndrome
Interventions
sleep-wake timing, constant routine
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens

NCT04792697
View directory record Official record
Conditions
Delayed Sleep Phase Syndrome
Interventions
Increase morning bright light, Decrease evening blue light, Sleep Scheduling, Monitor sleep, mood, and substance use
Other · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 15 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 1 Interventional

Treatment Strategies for Children With Smith-Magenis Syndrome

NCT00506259
View directory record Official record
Conditions
Developmental Delay Disorders, Chromosome Deletion, Mental Retardation, Sleep Disorders, Circadian Rhythm, Self Injurious Behavior
Interventions
dTR Melatonin (NIH CC PDS), Phototherapy (Bright Light), Melatonin CR
Drug · Device
Lead sponsor
National Human Genome Research Institute (NHGRI)
NIH
Eligibility
3 Years to 45 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Jul 19, 2026, 10:18 AM EDT
Not listed Not applicable Interventional

The Reducing Risk Study

NCT03665337
View directory record Official record
Conditions
Insomnia, Delayed Sleep Phase
Interventions
mTranS-C, Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 18 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Glasses for Adolescent Delayed Sleep-Wake Phase Disorder

NCT04378933
View directory record Official record
Conditions
Delayed Sleep-Wake Phase Disorder
Interventions
Amber Glasses, Clear Lens Glasses
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
14 Years to 17 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
Chicago, Illinois • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Jul 19, 2026, 10:18 AM EDT
Recruiting Phase 3 Interventional

Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)

NCT04652882
View directory record Official record
Conditions
Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
Interventions
Tasimelteon, Placebo
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
11
States / cities
Los Angeles, California • Redwood City, California • Aurora, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Delayed Sleep Timing in Teens Study

NCT03806296
View directory record Official record
Conditions
Delayed Sleep Phase
Interventions
Increase morning bright light, Decrease evening blue light, Sleep scheduling, Monitor sleep, mood, and substance use
Other · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
16 Years to 19 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 25, 2025 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional

Improving Access to Care: Testing an Integrated Care Mobile Health Intervention

NCT03780088
View directory record Official record
Conditions
Insomnia, Delayed Sleep Phase
Interventions
mTranS-C
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
12 Years to 18 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Atherton, California
Source: ClinicalTrials.gov public record
Updated Aug 16, 2021 · Synced Jul 19, 2026, 10:18 AM EDT
Completed No phase listed Observational

Validation of Circadian Biomarkers in Patients With Sleep Disorders

NCT04690504
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS), Delayed Sleep Phase Syndrome, Sleep Wake Disorders, Sleep Disorder
Interventions
dim light melatonin onset (DLMO)
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 1 Interventional

A Study of HBS-201 (Pitolisant Delayed-release)

NCT07051252
View directory record Official record
Conditions
Narcolepsy
Interventions
HBS-201
Drug
Lead sponsor
Harmony Biosciences Management, Inc.
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
15
States / cities
San Ramon, California • Brandon, Florida • Miami, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Results available

Blue Wavelength Light-blocking Glasses in ADHD-Insomnia

NCT01557595
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Delayed Sleep Phase Type Circadian Rhythm Sleep Disorder
Interventions
Polarized glasses designed to filter out blue light
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 12, 2017 · Synced Jul 19, 2026, 10:18 AM EDT
Recruiting Phase 4 Interventional

Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)

NCT01406691
View directory record Official record
Conditions
Delayed Sleep Phase Disorder
Interventions
Flashes
Device
Lead sponsor
Stanford University
Other
Eligibility
15 Years to 19 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Light Sensitization Study

NCT01327040
View directory record Official record
Conditions
Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
Interventions
light exposure
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 30 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 2 Interventional Results available

Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome

NCT00593736
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
42
States / cities
Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 39 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2012 · Synced Jul 19, 2026, 10:18 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Breath Biomarkers for Sleep Loss and Circadian Timing

NCT03980340
View directory record Official record
Conditions
Shift-Work Sleep Disorder, Shift Work Type Circadian Rhythm Sleep Disorder, Sleep Disorders, Circadian Rhythm, Sleep Disorders, Intrinsic, Advanced Sleep Phase Syndrome (ASPS), Advanced Sleep Phase Syndrome, Advanced Sleep Phase, Delayed Sleep Phase, Delayed Sleep Phase Syndrome, Non-24 Hour Sleep-Wake Disorder, Irregular Sleep-Wake Syndrome
Interventions
Short Nap Intervention, No Nap Intervention
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Jul 19, 2026, 10:18 AM EDT
Recruiting Not applicable Interventional

Pupillometry in Delayed Sleep Wake Phase Disorder

NCT06949644
View directory record Official record
Conditions
Delayed Sleep-Wake Phase Disorder
Interventions
Light and Citalopram
Combination Product
Lead sponsor
Northwestern University
Other
Eligibility
16 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics (PK) of Oral TAK-994 in an Acute Sleep Phase Delay Paradigm in Healthy Male Participants

NCT04551079
View directory record Official record
Conditions
Healthy Volunteers
Interventions
TAK-994, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 18, 2021 · Synced Jul 19, 2026, 10:18 AM EDT
Terminated Not applicable Interventional

Chronotherapy Randomized Controlled Trial

NCT02176824
View directory record Official record
Conditions
Major Depressive Disorder, Bipolar Depression, Suicidal Ideation
Interventions
Total Sleep deprivation, Sleep Phase Advance, and Bright Light Therapy, Partial Sleep deprivation, Sleep Phase Delay, and Low amber light., Treatment as usual
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years to 90 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Melatonin Treatment for Induced Transient Insomnia

NCT00950885
View directory record Official record
Conditions
Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
Interventions
Low Dose Melatonin, Placebo, High Dose Melatonin
Biological
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2017 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 4 Interventional

Lemborexant in Delayed Sleep Phase Syndrome

NCT05463861
View directory record Official record
Conditions
Delayed Sleep Phase Syndrome
Interventions
Lemborexant, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 3 Interventional Results available

The Clinical Utility of Measuring the Circadian Clock in Treatment of Delayed Sleep-Wake Phase Disorder

NCT03715465
View directory record Official record
Conditions
Delayed Sleep Phase Syndrome
Interventions
Melatonin 0.5 MG, Dim Light Melatonin Onset (salivary)
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 24, 2022 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Phase 3 Interventional Results available

SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia.

NCT03331042
View directory record Official record
Conditions
Transient Insomnia
Interventions
SM-1, D+Z, D+L, Placebo
Drug
Lead sponsor
Sequential Medicine Ltd
Industry
Eligibility
18 Years and older
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Jul 19, 2026, 10:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Circadian Phase Assessments at Home

NCT01487252
View directory record Official record
Conditions
Healthy Controls, Delayed Sleep Phase
Interventions
At home saliva sampling
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 69 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Jul 19, 2026, 10:18 AM EDT
Recruiting Phase 2 Interventional

Correcting Circadian Rhythms to Breakthrough in Bipolar Disorder

NCT06226025
View directory record Official record
Conditions
Bipolar Disorder, Delayed Sleep-Wake Phase Disorder
Interventions
Melatonin, Placebo, Behavioral sleep intervention, Behavioral sleep control
Drug · Other · Behavioral
Lead sponsor
Leslie Swanson
Other
Eligibility
18 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 19, 2026, 10:18 AM EDT