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Showing 1–24 of 44 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Delirium in Old Age Clear all
Completed Phase 3 Interventional Accepts healthy volunteers

A Clinical Trial of Intravenous Lidocaine After Spinal Surgery to Prevent Delirium and Reduce Pain

NCT05010148
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Pain, Spinal Fusion
Interventions
Lidocaine IV, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
60 Years and older
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)

NCT04007523
View directory record Official record
Conditions
Delirium
Interventions
Family Support System, HELP Support System
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
70 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Sep 26, 2026, 2:28 AM EDT
Withdrawn Phase 4 Interventional

Ramelteon vs Placebo for Prevention of Delirium and Improvement of Sleep in Hospitalized Older Adults

NCT03165695
View directory record Official record
Conditions
Delirium in Old Age
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional

fMRI Connectivity in Fracture Hip Patients

NCT02997930
View directory record Official record
Conditions
Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
fMRI, Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy, Wide Range Achievement Test reading subtest, Hopkins Verbal Learning Test (HVLT), General Depression Scale (GDS)
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
65 Years to 99 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Sep 26, 2026, 2:28 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study

NCT06036095
View directory record Official record
Conditions
Neurocognitive Disorders, Anesthesia, Post-operative Delirium, Post-operative Cognitive Dysfunction
Interventions
Sevoflurane, Propofol
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
70 Years to 110 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 7, 2024 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Phase 3 Interventional Results available

A Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium

NCT00865202
View directory record Official record
Conditions
Post-operative Delirium
Interventions
L-tryptophan supplementation, placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
60 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated May 31, 2017 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant

NCT05733286
View directory record Official record
Conditions
Delirium in Old Age
Interventions
Suvorexant 20 mg, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
65 Years and older
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Active, not recruiting Not applicable Interventional

Nutritional Therapy for Delirium in Elderly Hospitalized Subjects

NCT05066503
View directory record Official record
Conditions
Subacute Delirium
Interventions
260279 active study product
Dietary Supplement
Lead sponsor
University of Arkansas
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Active, not recruiting No phase listed Observational

Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

NCT03839784
View directory record Official record
Conditions
Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium, Anesthesia; Reaction, Anesthesia; Adverse Effect
Interventions
Neurocognition Interventions
Combination Product
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Phase 4 Interventional Results available

Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly

NCT01951118
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Delirium, Dementia, Amnestic, Cognitive Disorders
Interventions
Donepezil
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
55 Years to 95 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 12, 2020 · Synced Sep 26, 2026, 2:28 AM EDT
Completed No phase listed Observational

Sleep & Postoperative Delirium in Hispanic/ Latino Patients After Cardiothoracic Surgery

NCT04786899
View directory record Official record
Conditions
Delirium in Old Age, Sleep Disturbance, Circadian Rhythm Sleep Disorder
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
50 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 28, 2022 · Synced Sep 26, 2026, 2:28 AM EDT
Completed No phase listed Observational

Delirium in Persons With Dementia

NCT01394328
View directory record Official record
Conditions
Delirium Superimposed on Dementia
Interventions
Not listed
Lead sponsor
Penn State University
Other
Eligibility
65 Years and older
Enrollment
308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 15, 2018 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Eyecontrol coMmunication Platform for dEliRium manaGemEnt in Intensive Care Units (EMERGE)

NCT06029244
View directory record Official record
Conditions
Delirium, Delirium in Old Age, Critical Illness, Intensive Care Unit Delirium
Interventions
EyeControl-Pro, Control
Device · Other
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
50 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional

The Effect of White and Pink Noise on Hospitalized Older Adults

NCT03485183
View directory record Official record
Conditions
Delirium in Old Age
Interventions
White/Pink Noise, Control Group
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 9, 2019 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Results available

Post-Operative Delirium in Elderly Surgical Patients

NCT00590707
View directory record Official record
Conditions
Hip Fractures, Delirium
Interventions
Deeper sedation, Moderate sedation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 10, 2018 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Using EMR Data and AI to Develop a Passive Digital Marker to Predict Postoperative Delirium

NCT06216483
View directory record Official record
Conditions
Delirium in Old Age
Interventions
PDM Alert
Other
Lead sponsor
Indiana University
Other
Eligibility
65 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Recruiting Phase 3 Interventional

The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium

NCT06721819
View directory record Official record
Conditions
Delirium, Postoperative, Delirium in Old Age
Interventions
Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control
Combination Product · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
406 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
3
States / cities
Boston, Massachusetts • New York, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Stanford PIPRA Validation Study in an Elderly Orthopedic Population

NCT06567574
View directory record Official record
Conditions
Delirium, Postoperative Delirium, Cognitive Impairment
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 26, 2026, 2:28 AM EDT
Terminated Phase 2 Interventional

The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery

NCT06434948
View directory record Official record
Conditions
Postoperative Delirium
Interventions
Omega-3 Ethyl Esters 4 g, Omega-3 Ethyl Esters 2 g
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
65 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 26, 2026, 2:28 AM EDT
Completed No phase listed Observational

Delirium in the Emergency Department and Its Extension Into Hospitalization

NCT01651897
View directory record Official record
Conditions
Delirium
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
65 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Phase 2 Interventional Results available

Cardiac Surgery Neuroprotection Study in Elders

NCT01561378
View directory record Official record
Conditions
Post-operative Cognitive Decline, Post-operative Delirium
Interventions
Aspart insulin, Normal saline, Intranasal mucosal atomizer device
Drug · Device
Lead sponsor
Albert Einstein College of Medicine
Other
Eligibility
65 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 9, 2021 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preventative Delirium Protocol in Elderly Patients

NCT03541408
View directory record Official record
Conditions
Delirium
Interventions
Control, Preventative Delirium Protocol
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
65 Years to 89 Years
Enrollment
263 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 11, 2022 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trajectory of Recovery in the Elderly

NCT02275026
View directory record Official record
Conditions
Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
Functional magnetic resonance imaging
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
40 Years to 80 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Sep 26, 2026, 2:28 AM EDT
Completed Not applicable Interventional

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

NCT00212147
View directory record Official record
Conditions
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interventions
General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
60 Years and older
Enrollment
444 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
2
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Sep 26, 2026, 2:28 AM EDT