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Showing 1–24 of 89 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Paraesophageal Hernia
Interventions
POSTERIOR RECTUS SHEATH HIATAL AUGMENTATION (PORSHA)
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair

NCT06444347
Conditions
Hiatal Hernia
Interventions
Biosynthetic Mesh, Hiatal Hernia Repair
Device · Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
6
States / cities
Los Angeles, California • New Orleans, Louisiana • St Louis, Missouri + 1 more
Conditions
General Laparoscopic Surgery Candidate, Bariatric Laparoscopic Surgery Candidate
Interventions
AutoLap
Device
Lead sponsor
M.S.T. Medical Surgery Technology LTD.
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Burlington, Massachusetts
Conditions
Paraesophageal Hernia
Interventions
Not listed
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Grand Rapids, Michigan
Conditions
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
1 Day to 30 Days
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Houston, Texas
Conditions
Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Conditions
Severe Congenital Diaphragmatic Hernia
Interventions
Goldballoon Detachable Balloon (GOLDBAL2)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
New York, New York
Conditions
Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Reflux, Gastroesophageal, Reflux Acid
Interventions
LINX Reflux Management System, Fundoplication
Device · Procedure
Lead sponsor
Foregut Research Foundation
Other
Eligibility
21 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
6
States / cities
Los Angeles, California • Lone Tree, Colorado • Coral Springs, Florida + 3 more
Conditions
Congenital Diaphragmatic Hernia
Interventions
Fetoscopic Endoluminal Tracheal Occlusion Surgery
Device
Lead sponsor
Hanmin Lee
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2028
U.S. locations
1
States / cities
San Francisco, California
Conditions
Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula, Esophageal Atresia
Interventions
Thoracoscopic surgery
Procedure
Lead sponsor
Arlyne Thung
Other
Eligibility
Up to 6 Months
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions
TIF Transoral Fundoplication, Sham placebo procedure
Device · Other
Lead sponsor
EndoGastric Solutions
Industry
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
9
States / cities
Los Angeles, California • Englewood, Colorado • Chicago, Illinois + 5 more
Conditions
Congenital Diaphragmatic Hernia, Congenital Abnormalities, Neonatal Diseases and Abnormalities, Hernia, DIaphragmatic, Congenital, Internal Hernia, Hernia, Pathological Conditions, Anatomical, Pathological Conditions, Signs and Symptoms
Interventions
Fetal Treatment Arm (FETO Group)
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2031
U.S. locations
1
States / cities
Baltimore, Maryland
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia

NCT05953428
Conditions
Hiatal Hernia
Interventions
Opioid Sparing Anesthesia Protocol (OSA), Opioid Based Anesthesia Protocol (OBA)
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Evanston, Illinois
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Fundoplication in Laparoscopic PEH Repair Based on FLIP

NCT05807763
Conditions
Paraesophageal Hernia
Interventions
Laparoscopic paraesophageal hernia repair without fundoplication
Procedure
Lead sponsor
The Foundation for Surgical Innovation and Education
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
2
States / cities
Evanston, Illinois • Portland, Oregon
Conditions
Congenital Diaphragmatic Hernia
Interventions
Fetal Endotracheal Occlusion (FETO)
Device
Lead sponsor
Eyal Krispin
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Hiatal Hernia
Interventions
Veritas® Collagen Matrix
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia
Interventions
GoldBAL2 Detachable Balloon and BALTACCIBDPE100 Delivery Catheter
Device
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Not listed No phase listed Observational Accepts healthy volunteers

Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia

NCT01098929
Conditions
Congenital Diaphragmatic Hernia
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Congenital Diaphragmatic Hernia
Interventions
Balt "Goldballoon"
Device
Lead sponsor
Yair Blumenfeld
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Stanford, California
Completed Not applicable Interventional Results available

Miromatrix Biological Mesh for Hiatal Hernia Repair

NCT02436681
Conditions
Hiatal Hernia
Interventions
MIROMESH
Device
Lead sponsor
Miromatrix Medical Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Lexington, Kentucky • Long Branch, New Jersey • Charlotte, North Carolina + 3 more
Conditions
Congenital Diaphragmatic Hernia, Pulmonary Hypertension
Interventions
Sildenafil Oral Suspension, Placebo
Drug · Other
Lead sponsor
University of Utah
Other
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Conditions
Congenital Diaphragmatic Hernia
Interventions
FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100)
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Sacramento, California
Conditions
Hiatal Hernia, Interstitial Lung Disease
Interventions
Blood Collection, Bronchoscopy
Diagnostic Test
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Conditions
Twin to Twin Transfusion Syndrome, Congenital Diaphragmatic Hernia, Neural Tube Defects, Lower Urinary Tract Infection
Interventions
Automated Myocardial Performance Index (MPI)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota