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Showing 1–24 of 26 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Distal Femur Fracture Clear all
Completed Not applicable Interventional

Trial of a Distal Targeting System for Cephalomedullary Nails as Part of Surgical Repair of Hip and Femoral Shaft Fractures

NCT03943329
View directory record Official record
Conditions
Hip Fractures, Femoral Shaft Fractures
Interventions
Standard of Care, Distal targeting device technique of distal screw placement
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 13, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Completed No phase listed Observational

Plating of Distal Femur Fractures by Far Cortical Locking Using MotionLoc Screws

NCT01667887
View directory record Official record
Conditions
Fracture of Distal Femur
Interventions
Not listed
Lead sponsor
Legacy Biomechanics Laboratory
Other
Eligibility
17 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 28, 2013 · Synced Jul 21, 2026, 6:07 PM EDT
Withdrawn No phase listed Observational

Mobile Weight-Support Therapy (MWeST) for Mobility After Geriatric Fracture

NCT03864367
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Device - Prism Medical FGA-700 Bariatric Floor Lift
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 6, 2021 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated Phase 4 Interventional Results available

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

NCT01693367
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
21 Years to 120 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Sacramento, California • Columbia, Missouri • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Early Advanced Weight Bearing for Peri-articular Knee and Pilon Injuries

NCT03562364
View directory record Official record
Conditions
Distal Femur Fracture, Tibial Plateau Fracture, Distal Tibia Fracture, Pilon Fracture
Interventions
AlterG anti-gravity treadmill
Other
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 55 Years
Enrollment
81 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
10
States / cities
San Diego, California • San Francisco, California • Lexington, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Early Weight Bearing on Supracondylar Distal Femur Fractures in Elderly Patients

NCT02475941
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
Non Weight bearing, Early Weight Bearing
Other
Lead sponsor
St. Louis University
Other
Eligibility
64 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
6
States / cities
Atlanta, Georgia • St Louis, Missouri • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated Not applicable Interventional Results available

TRIGEN SURESHOT™ Distal Targeting System Study

NCT01327508
View directory record Official record
Conditions
Femoral Shaft Fracture
Interventions
TRIGEN SURESHOT Distal Targeting Instrumentation., Free-hand technique
Device · Other
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
6
States / cities
Sacramento, California • Gainesville, Florida • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2018 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Single Versus Dual Implant Fixation of Distal Femur Fractures

NCT06286670
View directory record Official record
Conditions
Articular Fractures
Interventions
Single Implant Fixation, Dual Implant Fixation
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
16
States / cities
Birmingham, Alabama • Los Angeles, California • Atlanta, Georgia + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Immediate Weight Bearing Versus Protected Weight Bearing in Supracondylar Distal Femur Fractures

NCT03167099
View directory record Official record
Conditions
Closed Supracondylar Fracture of Femur
Interventions
Full Weight Bearing
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 4, 2022 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting No phase listed Observational

Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS®

NCT04113044
View directory record Official record
Conditions
Hip Fractures, Tibial Fractures, Ankle Fractures, Humeral Fracture, Proximal, Distal Radius Fracture
Interventions
All treatments will remain the standard (routine) care procedures based on individual clinician's judgment and the patient characteristics.
Other
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Timeline
2021 – 2026
U.S. locations
4
States / cities
Los Angeles, California • Miami, Florida • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed No phase listed Observational

RFN-Advanced Retrograde Femoral Nailing System

NCT05668117
View directory record Official record
Conditions
Femur Fracture
Interventions
Depuy Synthes Advanced Retrograde femoral nail
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Apr 30, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Completed No phase listed Observational

Locking Plates for Distal Femur Fractures - a Multicenter Case Review

NCT04008940
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Distal femur plates
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2025
U.S. locations
3
States / cities
Sacramento, California • Houston, Texas • Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

NCT05792189
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

Distal Targeter vs Free-hand

NCT05613257
View directory record Official record
Conditions
Femur Fracture, Tibial Fractures, Nonunion of Fracture, Nonunion of Fracture of Tibia, Nonunion of Fracture of Femur (Diagnosis), Tibia Fracture
Interventions
Distal targeting jig, Free-hand/perfect circles technique
Device · Procedure
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Not listed No phase listed Observational

Radiostereometric Analysis of Fracture Healing in Distal Femur Fractures

NCT01593176
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
Placement of RSA beads
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2015 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures

NCT00429663
View directory record Official record
Conditions
Femoral Fractures
Interventions
reamed, interlocking intramedullary nail, locking periarticular plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
Not listed
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
22
States / cities
Sacramento, California • Tampa, Florida • Indianapolis, Indiana + 18 more
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures

NCT05680987
View directory record Official record
Conditions
Femoral Fracture
Interventions
RFN-Advanced Retrograde Femoral Nailing System
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Completed Not applicable Interventional

Distal Locking Using an Electromagnetic Field Guided Computer Based Real Time System for Orthopaedic Trauma Patients

NCT01183078
View directory record Official record
Conditions
Tibial Fractures, Femoral Fractures
Interventions
free-hand, Wand technique
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2023 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

NCT03076034
View directory record Official record
Conditions
Distal Radius Fracture, Osteoporosis, Hip Fractures
Interventions
Reference Point Indentation
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
50 Years to 100 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 21, 2026, 6:07 PM EDT
Active, not recruiting Not applicable Interventional

Dual Implant Versus Single Implant Distal End of Femur

NCT06032299
View directory record Official record
Conditions
Femur Fracture
Interventions
Single Distal Femur Implant, Dual Distal Femur Implant
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Recruiting Not applicable Interventional

Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures

NCT07280169
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 21, 2026, 6:07 PM EDT
Withdrawn Phase 4 Interventional

Supracondylar Distal Femur Fractures and Abaloparatide

NCT04626141
View directory record Official record
Conditions
Femoral Fractures
Interventions
Abaloparatide, Placebo
Drug
Lead sponsor
Daniel Horwitz
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Jul 21, 2026, 6:07 PM EDT
Terminated Not applicable Interventional

Reamed Locked Plating - Metaphyseal Fractures of the Distal Femur and Tibia

NCT01553630
View directory record Official record
Conditions
Femoral Fractures, Tibial Fractures
Interventions
RIA bone graft, Surgery without bone graft
Procedure
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
18 Years to 90 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 10, 2014 · Synced Jul 21, 2026, 6:07 PM EDT
Enrolling by invitation Not applicable Interventional

Dual Implant Versus Single Implant Distal End of Femur

NCT05292313
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Single distal femur implant, Dual distal femur implants
Procedure
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Rochester, Minnesota • New York, New York • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 21, 2026, 6:07 PM EDT