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Showing 1–15 of 15 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Diving Clear all
Completed Early Phase 1 Interventional Accepts healthy volunteers

Prevention and Treatment of Immersion Pulmonary Edema

NCT00815646
View directory record Official record
Conditions
Immersion Pulmonary Edema (IPE), Swimming Induced Pulmonary Edema (SIPE)
Interventions
Sildenafil
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2016 · Synced Sep 6, 2026, 5:45 PM EDT
Recruiting Phase 3 Interventional Accepts healthy volunteers

Exploring Sympathetic Nervous System Function in Individuals With Down Syndrome

NCT07238465
View directory record Official record
Conditions
Down Syndrome, Autonomic Dysfunction
Interventions
Fear Response, Cold Stress, Pain Response, Caffeine, 12-Hour Fast, Maximal Dynamic Exercise
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 6, 2026, 5:45 PM EDT
Recruiting Not applicable Interventional

Deployment of Irrigating Intraventricular Catheter System for Intraventricular Hemorrhage

NCT05970549
View directory record Official record
Conditions
Intraventricular Hemorrhage (IVH)
Interventions
IRRAflow® Active Fluid Exchange System, Traditional extraventricular drain, Non-contrast head CTs
Device · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

NCT02064361
View directory record Official record
Conditions
Decompression Sickness, SCUBA Diving
Interventions
High intensity exercise
Other
Lead sponsor
University of Split
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 16, 2014 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention

NCT03686813
View directory record Official record
Conditions
Edema, Pulmonary, Immersion, Diving
Interventions
Sildenafil Citrate, Placebo Oral Tablet
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 45 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 21, 2022 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Common Recreational Diving Practices: A Randomized Control Trial Using Pre-Dive Checklist

NCT01960738
View directory record Official record
Conditions
Injuries
Interventions
A pre-dive checklist
Other
Lead sponsor
Divers Alert Network
Network
Eligibility
18 Years and older
Enrollment
1,116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Wilmington, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2013 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Deep Dive Randomized Control Trial

NCT00793260
View directory record Official record
Conditions
Chronic Disease, Arthritis, Uterine Diseases, Spinal Diseases, Preventive Health Services
Interventions
Enhanced Support, Usual-Support
Behavioral
Lead sponsor
Health Dialog
Industry
Eligibility
Not listed
Enrollment
174,120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated Nov 18, 2008 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 2)

NCT05831228
View directory record Official record
Conditions
Oxygen Toxicity
Interventions
Ketogenic food products, Control: Placebo
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years to 39 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Results available

Does an Occupational Therapy Program Enhance Mental Health Outcomes for Veterans Who Scuba Dive

NCT03928392
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Depression, Anxiety, Stress, Psychological
Interventions
SCUBA with Occupational Therapy (OT), Self-Contained Underwater Breathing Apparatus (SCUBA) without OT
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 95 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Decompression Tables for Diving at Altitude

NCT03390335
View directory record Official record
Conditions
Decompression Sickness, Acute Mountain Sickness
Interventions
Pressure, Breathing Gas
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 40 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 13, 2021 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension?

NCT03945643
View directory record Official record
Conditions
Patent Foramen Ovale, Intrapulmonary Arteriovenous Anastamosis
Interventions
Sildenafil, Placebo
Drug · Other
Lead sponsor
University of Oregon
Other
Eligibility
18 Years to 65 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Pre-dive Ketone Food Products on Latency to CNS Oxygen Toxicity (Aim 1)

NCT05801120
View directory record Official record
Conditions
Oxygen Toxicity
Interventions
Ketogenic food products
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
18 Years to 39 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise and Repetitive Diving

NCT02118207
View directory record Official record
Conditions
Decompression Sickness, Endothelial Dysfunction, Neutrophil Activation, Venous Gas Emboli
Interventions
Aerobic running exercise
Other
Lead sponsor
University of Split
Other
Eligibility
18 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 20, 2014 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation

NCT01976429
View directory record Official record
Conditions
Middle-ear Barotrauma
Interventions
flight/diving simulation, ET function testing at ambient pressure, nasal video-endoscopy
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
10 Years to 50 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 6, 2019 · Synced Sep 6, 2026, 5:45 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Hypercapnia: Cognitive Effects and Monitoring

NCT01782625
View directory record Official record
Conditions
Hypercapnia, Exercise, Nitrogen Narcosis, Diving, Immersion
Interventions
NO exercise at depth, exercise at depth
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated May 24, 2016 · Synced Sep 6, 2026, 5:45 PM EDT