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ClinicalTrials.gov public records Last synced Sep 16, 2026, 5:41 PM EDT

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Showing 1–24 of 81 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Emergence Delirium, Anesthesia Clear all
Terminated Not applicable Interventional

TSA Exercise Prehabilitation in Older Adults

NCT03212300
View directory record Official record
Conditions
Postoperative Delirium and Delayed Functional Recovery
Interventions
Aerobic Exercise Training (AET)
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years to 75 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2020 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Monochromatic Light on Incidence of Emergence Delirium in Children

NCT03285243
View directory record Official record
Conditions
Emergence Delirium, Anesthesia Emergence Delirium
Interventions
Monochromatic blue light
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
2 Years to 6 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Sep 16, 2026, 5:41 PM EDT
Completed No phase listed Observational

Effect of Duration of Exposure of Anesthesia With Sevoflurane on Emergence Delirium

NCT02509221
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
1 Year to 6 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

NCT02856594
View directory record Official record
Conditions
Postoperative Delirium, Sleep, Anesthesia
Interventions
Dexmedetomidine, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
469 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State

NCT06133842
View directory record Official record
Conditions
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities, Intraoperative Hypotension, Cerebral Hypoperfusion
Interventions
Intra-op EEG and CO data collection
Diagnostic Test
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cerebral Oxygenation in Total Hip Arthroplasty Patients

NCT02325154
View directory record Official record
Conditions
Cerebral Oxygen Desaturation, Post-operative Delirium
Interventions
Cerebral Oximeter
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Sep 16, 2026, 5:41 PM EDT
Terminated Not applicable Interventional

iPad for Post Operative Pain After Tonsillectomy

NCT07770529
View directory record Official record
Conditions
Pain
Interventions
iPad, Intervention Control
Device · Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
3 Years to 10 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Phase 4 Interventional Results available

Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care

NCT01993836
View directory record Official record
Conditions
Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
Interventions
Total intravenous anesthesia with propofol, General anesthesia with isoflurane
Drug
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
191 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Sep 16, 2026, 5:41 PM EDT
Recruiting Phase 3 Interventional

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

NCT06624592
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Sevoflurane, Isoflurane
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
2 Years to 7 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Phase 4 Interventional Results available

Suvorexant and Sleep/Delirium in ICU Patients

NCT04092894
View directory record Official record
Conditions
Insomnia, Sleep Fragmentation, Sleep Initiation and Maintenance Disorders, Postoperative Delirium
Interventions
Suvorexant 20 mg, Placebo oral tablet
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
2
States / cities
Boston, Massachusetts • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Completed No phase listed Observational Results available

A Study to Evaluate ICU Simulation Experience in the Cardiothoracic Surgical Population to Reduce Post-operative Delirium

NCT05159648
View directory record Official record
Conditions
Post-Operative Delirium
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 60 Years
Enrollment
234 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 7, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional

Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery

NCT06326983
View directory record Official record
Conditions
Tonsillitis, Post-operative Nausea and Vomiting (PONV), Emergence Delirium, Opioid Analgesic Adverse Reaction, Anesthesia, Pain
Interventions
Dexmedetomidine, Acetaminophen, Ketorolac, Morphine
Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years to 17 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional

Post Anesthesia Care Unit (PACU) Weighted Blanket Study

NCT05632640
View directory record Official record
Conditions
Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
Interventions
Standard of Care, Weighted blanket
Other · Device
Lead sponsor
University of Michigan
Other
Eligibility
3 Years to 17 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Phase 2 Interventional Results available

Daridorexant to Prevent Delirium After Heart Surgery

NCT06630390
View directory record Official record
Conditions
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Interventions
Daridorexant 50 mg, Placebo
Drug · Other
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 16, 2026, 5:41 PM EDT
Recruiting Not applicable Interventional

Language During Inhalational Induction

NCT06324955
View directory record Official record
Conditions
Emergence Delirium, Anesthesia; Adverse Effect
Interventions
Standard/common language during induction, Positive language during induction
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
5 Years to 10 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Trajectory of Recovery in the Elderly

NCT02275026
View directory record Official record
Conditions
Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
Interventions
Functional magnetic resonance imaging
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
40 Years to 80 Years
Enrollment
104 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 14, 2021 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery

NCT03062488
View directory record Official record
Conditions
Emergence Agitation, Pain
Interventions
IV acetaminophen, Fentanyl, PO acetaminophen
Drug
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
24 Months to 7 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 16, 2026, 5:41 PM EDT
Completed Not applicable Interventional Results available

Preoperative Gabapentin for Post-tonsillectomy Pain in Children

NCT01707420
View directory record Official record
Conditions
Post Operative Pain Management in Children With Tonsillectomy/Adenoidectomy
Interventions
Gabapentin, liquid placebo
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
5 Years to 16 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 14, 2021 · Synced Sep 16, 2026, 5:41 PM EDT
Enrolling by invitation Phase 4 Interventional Accepts healthy volunteers

Pediatric Delirium

NCT04669457
View directory record Official record
Conditions
Pediatric Delirium
Interventions
Intra-nasal Dexmedetomidine, Oral Midazolam
Drug
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
3 Months to 9 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Recruiting Not applicable Interventional

Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

NCT07610655
View directory record Official record
Conditions
Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
Interventions
Transcutaneous vagal nerve stimulation, Sham (No Treatment)
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients

NCT00417664
View directory record Official record
Conditions
Delirium
Interventions
Dexmedetomidine, Propofol, Midazolam
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 89 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 26, 2022 · Synced Sep 16, 2026, 5:41 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients

NCT04443517
View directory record Official record
Conditions
Postoperative Delirium
Interventions
Alpha Optimization, Emergence from anesthesia with Dexmedetomidine
Procedure · Behavioral
Lead sponsor
Columbia University
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Recruiting Not applicable Interventional

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

NCT06375265
View directory record Official record
Conditions
Insomnia, Postoperative Delirium, Delayed Neurocognitive Recovery, Postoperative Neurocognitive Disorder
Interventions
digital Cognitive Behavioral Therapy for Insomnia (dCBT-I), Sleep Health Education
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 16, 2026, 5:41 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine

NCT04746079
View directory record Official record
Conditions
Procedural Sedation, Emergence Delirium
Interventions
Positive Imagery Therapy
Behavioral
Lead sponsor
Mercy Health Ohio
Other
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 22, 2022 · Synced Sep 16, 2026, 5:41 PM EDT