Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Sep 10, 2026, 6:11 PM EDT

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Showing 1–24 of 146 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Interventions
Deep Brain Stimulation (DBS)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
23
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 19 more
Completed No phase listed Observational Accepts healthy volunteers

Movement Disorder Quantification Algorithm Development

NCT01534650
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Valley View, Ohio
Conditions
Essential Tremor
Interventions
Kinesia HomeView
Device
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
Not listed
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
2
States / cities
Chicago, Illinois • Houston, Texas
Conditions
Essential Tremor
Interventions
10 mg PRAX-114, 20 mg PRAX-114, and Placebo, 10 mg PRAX-114 or 20 mg PRAX-114
Drug
Lead sponsor
Praxis Precision Medicines
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
3
States / cities
Boca Raton, Florida • Farmington Hills, Michigan • Kirkland, Washington
Conditions
Movement Disorders (Incl Parkinsonism), Stroke, Traumatic Brain Injury, Brain Diseases, Parkinson Disease, Essential Tremor, Movement Disorders
Interventions
Direct cortical stimulation and deep brain stimulation of motor thalamus
Device
Lead sponsor
Jorge Gonzalez-Martinez
Other
Eligibility
18 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Conditions
Essential Tremor
Interventions
Cala Trio
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years and older
Enrollment
276 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
San Mateo, California
Conditions
Upper Limb Essential Tremor (UL ET)
Interventions
BOTOX, Placebo for BOTOX
Biological · Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years to 80 Years
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
36
States / cities
Hoover, Alabama • Phoenix, Arizona • Tucson, Arizona + 31 more
Terminated No phase listed Observational Results available

Brain Networks and Consciousness

NCT04502550
Conditions
Loss of Consciousness, Parkinson Disease, Essential Tremor, Anesthesia
Interventions
Propofol
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Essential Tremor
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Conditions
Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor, Vocal Tremor
Interventions
Propranolol, Botulinum Toxin
Drug · Procedure
Lead sponsor
Emory University
Other
Eligibility
45 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Atlanta, Georgia
Conditions
Epilepsy, Essential Tremor, Seizures, Memory Consolidation, Memory Disorders, Memory Replay, Memory Encoding, Cognitive Control, Motor Abilities
Interventions
Cobenfy KarXT pill (50/20 mg), Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Dallas, Texas
Conditions
Essential Tremor
Interventions
Transcranial ExAblate
Device
Lead sponsor
InSightec
Industry
Eligibility
22 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
7
States / cities
Stanford, California • Baltimore, Maryland • Boston, Massachusetts + 4 more
Conditions
Parkinson's Disease, Essential Tremor, Dystonia
Interventions
Activa RC
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
7 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
5
States / cities
Washington D.C., District of Columbia • Cincinnati, Ohio • Nashville, Tennessee + 2 more
Completed No phase listed Observational Accepts healthy volunteers

Environmental Epidemiology of Essential Tremor

NCT04576676
Conditions
Essential Tremor, Parkinson Disease
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years and older
Enrollment
1,497 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Recruiting Not applicable Interventional Accepts healthy volunteers

Attention and Eye Movement in Parkinson's Disease

NCT06899022
Conditions
Essential Tremor, Parkinson's Disease (PD), Dystonias
Interventions
Normal therapeutic DBS, Reduced current DBS, Reduced frequency DBS
Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 90 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Omaha, Nebraska
Completed Phase 4 Interventional Accepts healthy volunteers

A Pilot Clinical Trial Of Memantine for Essential Tremor

NCT00439699
Conditions
Essential Tremor
Interventions
Memantine
Drug
Lead sponsor
VA Greater Los Angeles Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Tremor, Essential, Parkinson's Disease
Interventions
Automatic DRT/VIM target-recognition method using MR-SISET and ML approaches, Routine clinical MRI protocol
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Recruiting Not applicable Interventional

Motor Network Physiology

NCT04957095
Conditions
Parkinson Disease, Essential Tremor
Interventions
Apomorphine Injectable Solution, Subcortical Stimulation
Drug · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Active, not recruiting Not applicable Interventional

Responsive Deep Brain Stimulator for Essential Tremor

NCT02649166
Conditions
Essential Tremor
Interventions
Deep brain stimulation, Closed-loop deep brain stimulation
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Conditions
Parkinson Disease, Essential Tremor, Dystonia
Interventions
Deep Brain Stimulation
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2030
U.S. locations
1
States / cities
St Louis, Missouri
Completed Not applicable Interventional Results available

Prospective Study for Symptomatic Relief of ET With Cala Therapy

NCT03597100
Conditions
Essential Tremor
Interventions
Cala TWO
Device
Lead sponsor
Cala Health, Inc.
Industry
Eligibility
22 Years and older
Enrollment
263 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
32
States / cities
Phoenix, Arizona • Los Angeles, California • Mountain View, California + 28 more
Conditions
Essential Tremor
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
2
States / cities
Chicago, Illinois • Houston, Texas
Conditions
Essential Tremor
Interventions
Transcranial ExAblate, Sham Transcranial ExAblate
Device
Lead sponsor
InSightec
Industry
Eligibility
22 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
5
States / cities
Stanford, California • Baltimore, Maryland • Boston, Massachusetts + 2 more
Conditions
Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor, Dyskinesias, Myoclonus, Tic Disorders, Torticollis, Ulnar Nerve Entrapment, Temporomandibular Joint Disorders, Dysphonia
Interventions
DystoniaNet-based diagnosis of isolated dystonia
Diagnostic Test
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts