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ClinicalTrials.gov public records Last synced Oct 28, 2026, 5:10 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 147 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Essential Tremor Clear all
Completed No phase listed Observational

Ethanol Response in Essential Tremor: Clinical and Neurophysiological Correlates

NCT01200966
View directory record Official record
Conditions
Essential Tremor
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
21 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 28, 2026, 5:10 PM EDT
Active, not recruiting No phase listed Observational

Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:

NCT03100474
View directory record Official record
Conditions
Essential Tremor, Parkinson's Disease, Movement Disorders, Neuropathic Pain
Interventions
Not listed
Lead sponsor
InSightec
Industry
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
5
States / cities
Stanford, California • Baltimore, Maryland • Philadelphia, Pennsylvania + 2 more
Source: ClinicalTrials.gov public record
Updated May 2, 2025 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting No phase listed Observational

ET Stigma Response to Tremor Suppression

NCT07430761
View directory record Official record
Conditions
Action Tremor, Stigma, Social
Interventions
stereotactic thalamotomy with focused ultrasound
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional Results available

Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)

NCT02909907
View directory record Official record
Conditions
Essential Tremor
Interventions
Botulinum toxin, Placebo
Drug · Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 8, 2019 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Phase 4 Interventional Results available

Propranolol and Botulinum Toxin for Essential Vocal Tremor

NCT02111369
View directory record Official record
Conditions
Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor, Vocal Tremor
Interventions
Propranolol, Botulinum Toxin
Drug · Procedure
Lead sponsor
Emory University
Other
Eligibility
45 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2016 · Synced Oct 28, 2026, 5:10 PM EDT
Not listed No phase listed Observational

Deep Brain Stimulation (DBS) Data Base Study

NCT01909531
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2023
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Oct 28, 2026, 5:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Movement Disorder Quantification Algorithm Development

NCT01534650
View directory record Official record
Conditions
Parkinson's Disease, Essential Tremor
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Valley View, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Phase 1 Interventional

1-Octanol to Treat Essential Tremor

NCT00016679
View directory record Official record
Conditions
Essential Tremor
Interventions
1-Octanol
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional

Modulatory Effects of Deep Brain Stimulation on Cerebral Cortical Activity

NCT04361955
View directory record Official record
Conditions
DBS, Parkinson Disease, Essential Tremor, Healthy
Interventions
EMG, EEG
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Early Phase 1 Interventional

Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor

NCT07599592
View directory record Official record
Conditions
Essential Tremor
Interventions
Low Intensity Focused Ultrasound (LIFU)
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Electrophysiological Study of the Effects of Limb Cooling on Essential Tremor

NCT01093027
View directory record Official record
Conditions
Tremor
Interventions
15 - 30, 30 - 15
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 95 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional Results available

Physiology, Imaging and Modeling of Essential Tremor

NCT03811405
View directory record Official record
Conditions
Essential Tremor, Parkinson Disease, Dystonia
Interventions
Active biphasic pulse stimulation---Home Settings, Active biphasic pulse stimulation---VIN Biphasic, Active biphasic pulse stimulation---Stimulator Off
Device
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
2
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Phase 1 Interventional

Coordinated Reset Deep Brain Stimulation for Essential Tremor

NCT05897775
View directory record Official record
Conditions
Essential Tremor, Upper Extremity Essential Tremor
Interventions
Deep brain stimulation
Device
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

NCT05366751
View directory record Official record
Conditions
Essential Tremor
Interventions
SAGE-324
Drug
Lead sponsor
Sage Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
38
States / cities
Hoover, Alabama • Scottsdale, Arizona • Fountain Valley, California + 32 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Phase 1 Interventional

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

NCT07049003
View directory record Official record
Conditions
Tremor, Essential Tremor
Interventions
Deep Brain Stimulation
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
21 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor

NCT03041714
View directory record Official record
Conditions
Essential Tremor, Cervical Dystonia, Focal Dystonia
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 1, 2018 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Not applicable Interventional

Deep Brain Stimulation Therapy in Movement Disorders

NCT02119611
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Deep Brain Stimulation management
Device
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 100 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Not applicable Interventional

Circadian Adaptive DBS in Essential Tremor

NCT06635811
View directory record Official record
Conditions
Essential Tremor, Essential Tremor (ET), Essential Tremor, Movement Disorders
Interventions
Circadian Adaptive DBS, Conventional DBS
Device
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 89 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Pilot Clinical Trial Of Memantine for Essential Tremor

NCT00439699
View directory record Official record
Conditions
Essential Tremor
Interventions
Memantine
Drug
Lead sponsor
VA Greater Los Angeles Healthcare System
Federal
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2012 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional

The Effects of Vibrotactile Stimulation in Patients With Movement Disorders

NCT05106816
View directory record Official record
Conditions
Parkinson Disease, Essential Tremor, Dystonia
Interventions
skin surface vibration, light skin surface vibration- SHAM
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting No phase listed Observational

Abbott DBS Post-Market Study of Outcomes for Indications Over Time

NCT04071847
View directory record Official record
Conditions
Movement Disorders, Parkinson Disease, Essential Tremor, Tremor, Dystonia, Primary Dystonia, Secondary Dystonia
Interventions
Deep Brain Stimulation (DBS)
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2030
U.S. locations
23
States / cities
Tucson, Arizona • Los Angeles, California • Sacramento, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Trial of Cannabis for Essential Tremor

NCT03805750
View directory record Official record
Conditions
Essential Tremor
Interventions
CBD/THC, Placebo oral capsule
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 13, 2022 · Synced Oct 28, 2026, 5:10 PM EDT
Recruiting Not applicable Interventional

Cortical-Basal Ganglia Speech Networks

NCT04286308
View directory record Official record
Conditions
Parkinson Disease, Essential Tremor, Dystonia
Interventions
electrophysiological data collection
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 85 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 28, 2026, 5:10 PM EDT
Completed Not applicable Interventional

Demand-driven Management of Essential Tremor

NCT02443181
View directory record Official record
Conditions
Essential Tremor
Interventions
Activa PC+S
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 16, 2022 · Synced Oct 28, 2026, 5:10 PM EDT