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Showing 1–24 of 88 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Executive Dysfunction Clear all
Completed No phase listed Observational Accepts healthy volunteers

Executive Dysfunction and Self-Harm Behavior: An Examination of Veterans With TBI, PTSD, or Both

NCT01334463
View directory record Official record
Conditions
Traumatic Brain Injury, Post Traumatic Stress Disorder, Suicide, Self-Injurious Behavior
Interventions
Not listed
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 45 Years
Enrollment
186 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 24, 2016 · Synced Sep 4, 2026, 9:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Connecting the Lab to Everyday Life: The Relevance of Executive Dysfunction to Participation and Quality of Life in Parkinson's Disease (PD) Without Dementia

NCT00917280
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
Washington University School of Medicine
Other
Eligibility
40 Years to 70 Years
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 2, 2015 · Synced Sep 4, 2026, 9:24 PM EDT
Active, not recruiting Not applicable Interventional

Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL)

NCT04105530
View directory record Official record
Conditions
Acute Lymphoblastic Leukemia, Transcranial Direct Current Stimulation, Executive Dysfunction
Interventions
Anodal tDCS treatment, Cathodal tDCS treatment, Sham treatment, NIH Toolbox List Sorting Working Memory Test, NIH Toolbox Flanker Inhibitory Control and Attention Test, Grooved Peg Board Test, Buschke Selective Reminding Test
Device · Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
8 Years to 215 Months
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 11, 2024 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations

NCT07424365
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
Interventions
transcutaneous auricular vagus nerve stimulation, sham stimulation
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional

High-Speed Yoga and Executive Function

NCT04215900
View directory record Official record
Conditions
Executive Dysfunction, Parkinson Disease, Quality of Life
Interventions
High-speed yoga multi-directional yoga
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
50 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated May 24, 2022 · Synced Sep 4, 2026, 9:24 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

LDX for the Treatment of Cognitive Functioning Issues in Women Post-Oophorectomy

NCT01986777
View directory record Official record
Conditions
Cognitive Impairments, RRSO
Interventions
lisdexamfetamine, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 60 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2017 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Not applicable Interventional

Non-invasive Brain Stimulation for Cognitive and Motor Dysfunction in Dementia

NCT05661084
View directory record Official record
Conditions
Dementia, Memory Loss, Alzheimer Disease, Executive Dysfunction, Mobility Limitation
Interventions
Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active), Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham), Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham), Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)
Device
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
55 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional

Online Emotion Regulation Group Intervention

NCT03479606
View directory record Official record
Conditions
Traumatic Brain Injury, Executive Dysfunction, Emotion Dysfunction, Emotion Dysregulation
Interventions
Online Emotion Regulation Skills-training
Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
137 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2022 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional Results available

Cognitive Training and tDCS for Children With FASD

NCT03361293
View directory record Official record
Conditions
Fetal Alcohol Spectrum Disorders
Interventions
Active tDCS, Cognitive training, Sham tDCS
Device · Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
10 Years to 16 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Sep 4, 2026, 9:24 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Maternal Choline Supplementation and Offspring Cognition in Adolescence

NCT05859126
View directory record Official record
Conditions
Cognitive Deficit in Attention, Executive Dysfunction, Emotional Regulation
Interventions
Maternal Choline Supplementation 930 mg/d, Maternal Choline Supplementation 480 mg/d
Dietary Supplement
Lead sponsor
Cornell University
Other
Eligibility
13 Years to 13 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ithaca, New York
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Phase 1Phase 2 Interventional

rTMS to Improve Cognition in Parkinson's

NCT03836950
View directory record Official record
Conditions
Parkinson's Disease, Mild Cognitive Impairment
Interventions
MagVenture MagProX100 stimulator (MagVenture, Falun, Denmark)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 20, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional Results available

Memantine for Executive Dysfunction in Adults With ADHD: A Pilot Study

NCT01533493
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Executive Function Deficits (EFD)
Interventions
Placebo, Memantine Hydrochloride, OROS-Methylphenidate
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 50 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2014 · Synced Sep 4, 2026, 9:24 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

WILD 5 Wellness: A 30-Day Intervention

NCT03272555
View directory record Official record
Conditions
Wellness, Anxiety, Depression, Cognitive and Executive Dysfunction
Interventions
WILD 5 Wellness Interventions
Other
Lead sponsor
Beloit College
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Beloit, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 25, 2018 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Not applicable Interventional

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

NCT05655325
View directory record Official record
Conditions
Mild Cognitive Impairment, Chronic Kidney Diseases
Interventions
Home-based walking exercise, Attention control
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
55 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Phase 1 Interventional

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

NCT07226219
View directory record Official record
Conditions
Sickle Cell Disease, Executive Dysfunction, Cognitive Impairment, Attention Deficit/Hyperactivity Disorder (ADHD)
Interventions
Extended-Release Methylphenidate
Drug
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
8 Years to 17 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Recruiting Phase 2 Interventional

Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment

NCT07097051
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI)
Interventions
real tACS, sham tACS
Other
Lead sponsor
High Point University
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bingocize: A Novel Mobile Application for Older Adult Health

NCT03629912
View directory record Official record
Conditions
Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis, Diabetes Mellitus, Type 2, Hypertension, Cognitive Decline, Executive Function, Cognitive Aging
Interventions
Socially-Based Exercise Intervention for Older Adults
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
60 Years to 85 Years
Enrollment
241 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
4
States / cities
Dixon, Kentucky • Henderson, Tennessee • Johnson City, Tennessee + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Sep 4, 2026, 9:24 PM EDT
Active, not recruiting Not applicable Interventional

Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD

NCT05131659
View directory record Official record
Conditions
Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
Interventions
Executive function group therapy
Behavioral
Lead sponsor
Children's National Research Institute
Other
Eligibility
14 Years to 18 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional

A Hybrid Effectiveness-implementation Trial of a High School-based Executive Function Treatment for Autistic Youth

NCT05017779
View directory record Official record
Conditions
Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
Interventions
Unstuck & On Target: High School, Treatment as Usual
Behavioral · Other
Lead sponsor
Children's National Research Institute
Other
Eligibility
14 Years to 22 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 4, 2026, 9:24 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Feasibility and Efficacy of rTMS in Healthy Persons

NCT04074811
View directory record Official record
Conditions
Executive Dysfunction, Pain, Mood
Interventions
Repetitive Transcranial Magnetic Stimulation (rTMS)
Device
Lead sponsor
Wayne State University
Other
Eligibility
21 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Sep 4, 2026, 9:24 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS

NCT05810454
View directory record Official record
Conditions
Parkinson's Disease, PD, Mild Cognitive Impairment, MCI
Interventions
iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
Device
Lead sponsor
iPACES LLC
Industry
Eligibility
50 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Clifton Park, New York
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 4, 2026, 9:24 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Sedation on Cognitive Performance in the Elderly

NCT03089866
View directory record Official record
Conditions
Postoperative Cognitive Dysfunction
Interventions
Midazolam (0.02mg/kg)
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
55 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 10, 2025 · Synced Sep 4, 2026, 9:24 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects

NCT00935493
View directory record Official record
Conditions
Cognitive Aging
Interventions
Guanfacine, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
75 Years and older
Enrollment
154 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 12, 2014 · Synced Sep 4, 2026, 9:24 PM EDT
Completed No phase listed Observational

Executive Function and Symptom Reduction in Youth Receiving Home-based Treatment With Collaborative Problem Solving

NCT04121650
View directory record Official record
Conditions
Child Behavior, Problem Behavior, Executive Dysfunction
Interventions
Collaborative Problem Solving
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
7 Years to 14 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 4, 2026, 9:24 PM EDT