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ClinicalTrials.gov public records Last synced Oct 21, 2026, 2:56 PM EDT

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Showing 25–48 of 75 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extubation Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

METEOR Think NIV Pilot

NCT04052542
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Traditional online continuing education, Interprofessional education, Just-in-time education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
1,328 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 6, 2021 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Phase 4 Interventional Results available

Quality of Recovery After Reversal With Neostigmine or Sugammadex.

NCT02909439
View directory record Official record
Conditions
Incomplete Reversal of Neuromuscular Block
Interventions
Sugammadex, Neostigmine
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated May 22, 2020 · Synced Oct 21, 2026, 2:56 PM EDT
Terminated Not applicable Interventional Results available

Postextubation Management in Patients at Risk for Extubation Failure

NCT04258020
View directory record Official record
Conditions
Ventilatory Failure
Interventions
BiPAP, HFNC
Device
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 13, 2022 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Not applicable Interventional

Comparing NAVA Levels in Intubated and Recently Extubated Neonates to Determine Optimal Non-invasive Ventilatory Support

NCT02048280
View directory record Official record
Conditions
Other Specified Respiratory Problems in Fetus or Neonate
Interventions
NAVA level, NAVA level
Procedure · Other
Lead sponsor
ProMedica Health System
Other
Eligibility
23 Weeks to 40 Weeks
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2015 · Synced Oct 21, 2026, 2:56 PM EDT
Withdrawn No phase listed Observational

Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population

NCT01795196
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 28, 2022 · Synced Oct 21, 2026, 2:56 PM EDT
Not yet recruiting Not applicable Interventional

Randomized Evaluation of Operating Room Extubation After Cardiac Surgery

NCT07757880
View directory record Official record
Conditions
Cardiac Surgery
Interventions
OR extubation, ICU extubation
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Phase 2Phase 3 Interventional

Nebulised Heparin in Patients With Severe COVID-19

NCT04545541
View directory record Official record
Conditions
Covid19, Respiratory Failure
Interventions
Nebulised unfractionated heparin (UFH)
Drug
Lead sponsor
Australian National University
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Frederick, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 5, 2025 · Synced Oct 21, 2026, 2:56 PM EDT
Recruiting Phase 2 Interventional

Corticosteroids for Post-Extubation Dysphagia

NCT06670521
View directory record Official record
Conditions
Dysphagia, Laryngeal Edema
Interventions
Methylprednisolone, Normal Saline
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Not listed No phase listed Observational

Predictors of Respiratory Failure Following Extubation in the SICU

NCT01967056
View directory record Official record
Conditions
Muscle Weakness, Renal Failure, Respiratory Comorbidities
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2013 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Weaning And Variability Evaluation

NCT01237886
View directory record Official record
Conditions
Mechanically Ventilated Patients, Extubation
Interventions
Not listed
Lead sponsor
Ottawa Hospital Research Institute
Other
Eligibility
18 Years and older
Enrollment
660 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
7
States / cities
Ann Arbor, Michigan • Billings, Montana • Lebanon, New Hampshire + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2017 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Post-extubation Assessment of Laryngeal Symptoms and Severity

NCT03726086
View directory record Official record
Conditions
Intubation, Intratracheal, Critical Illness, Mechanical Ventilation Complication, Complication of Ventilation Therapy
Interventions
laryngoscopy
Diagnostic Test
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 6, 2023 · Synced Oct 21, 2026, 2:56 PM EDT
Active, not recruiting Not applicable Interventional

The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial

NCT05523479
View directory record Official record
Conditions
Acute Respiratory Failure, Airway Extubation
Interventions
Traditional online education, Interprofessional education, Clinical protocol, Risk-stratified preventive post-extubation noninvasive ventilation (NIV) or high-flow nasal cannula oxygen (HFNC), Preventive post-extubation high-flow nasal cannula oxygen (HFNC)
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
13,018 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
17
States / cities
Carlisle, Pennsylvania • Hanover, Pennsylvania • Harrisburg, Pennsylvania + 7 more
Source: ClinicalTrials.gov public record
Updated May 8, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Extubation Criteria in Patients Greater Than 59 Years of Age

NCT04596735
View directory record Official record
Conditions
Extubation, Respiratory Complications
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Not applicable Interventional

Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients

NCT01095276
View directory record Official record
Conditions
Atelectasis, Ventilation, Mechanical
Interventions
Pulmozyme (nebulized dornase alpha), Saline
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2010 · Synced Oct 21, 2026, 2:56 PM EDT
Recruiting Not applicable Interventional

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

NCT05918575
View directory record Official record
Conditions
Obesity, Morbid, Extubation Failure
Interventions
Noninvasive ventilation alternating with high flow nasal cannula, High flow nasal cannula
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
4
States / cities
Chicago, Illinois • Winfield, Illinois • Houston, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Breathing Patterns in Infants Before and After Extubation

NCT07542301
View directory record Official record
Conditions
Respiratory Distress Syndrome (RDS), PreTerm Neonate
Interventions
Observation
Other
Lead sponsor
Christiana Care Health Services
Other
Eligibility
0 Days to 6 Months
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Withdrawn Not applicable Interventional

Early Extubation for Patients With Acute Hypoxemic Respiratory Failure

NCT04349332
View directory record Official record
Conditions
Mechanical Ventilation, Corona Virus Infection
Interventions
Helmet non-invasive ventilation (NIV)
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Oct 21, 2026, 2:56 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Deflated and Inflated Cuff Endotracheal Extubations

NCT06990308
View directory record Official record
Conditions
Anesthesia Airway Management, Respiratory Complications
Interventions
Inflated Cuff Extubation, Deflated Cuff Extubation
Procedure
Lead sponsor
Naval Medical Center Camp Lejeune
Federal
Eligibility
18 Years to 50 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Marine Corps Base Camp Lejeune, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 21, 2026, 2:56 PM EDT
Recruiting Not applicable Interventional

BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

NCT07204990
View directory record Official record
Conditions
Endotracheal Extubation, Airway Anesthesia, Paediatric
Interventions
Direct removal of endotracheal tube, Laryngeal mask airway inserted following deep extubation
Procedure
Lead sponsor
Telethon Kids Institute
Other
Eligibility
0 Years to 16 Years
Enrollment
1,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Mechanical Ventilation Discontinuation Practices

NCT03955874
View directory record Official record
Conditions
Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation, Tracheostomy, Direct Extubation
Interventions
Not listed
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
1,868 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
Boston, Massachusetts • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 2, 2021 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Not applicable Interventional

Early Identification and Prevention of Extubation Failure in Adults Using Integrated Pulmonary Index

NCT04231890
View directory record Official record
Conditions
Mechanical Ventilation Complication, Extubation
Interventions
IPI monitoring
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 8, 2021 · Synced Oct 21, 2026, 2:56 PM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness Study of Bubble CPAP Devices in the NICU

NCT02392806
View directory record Official record
Conditions
Respiratory Distress Syndrome
Interventions
Bubble CPAP- BabiPlus, Respiralogics, Bubble CPAP- B&B Bubbler, B&B Medical devices
Device
Lead sponsor
Marya Strand, MD
Other
Eligibility
1 Day to 100 Days
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2018 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Respiratory-Swallow Coordination in Cardiothoracic Surgical Patients

NCT05173207
View directory record Official record
Conditions
Thoracic Diseases, Cardiovascular Diseases
Interventions
Videofluoroscopic swallow exam with concurrent monitoring of respiratory-swallow coordination
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 90 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 21, 2026, 2:56 PM EDT
Completed No phase listed Observational

Extubation in Pediatric Patients: An Observational Study

NCT02963532
View directory record Official record
Conditions
Anesthesia, Pediatric
Interventions
We are observing criteria present at extubation
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
1 Month to 7 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2018 · Synced Oct 21, 2026, 2:56 PM EDT