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Showing 25–44 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Facet Joint Pain Clear all
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Analysis of Crepitus in Human Subjects

NCT05425017
View directory record Official record
Conditions
Low Back Pain, Healthy
Interventions
Range of motion with spinal adjustment
Other
Lead sponsor
National University of Health Sciences
Other
Eligibility
30 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Sep 29, 2026, 8:42 AM EDT
Terminated Phase 1 Interventional

Study Evaluating the Safety and Feasibility of Platelet-rich Plasma to Treat Facetogenic Low Back Pain

NCT05250947
View directory record Official record
Conditions
Lumbar Spondylosis
Interventions
Angel® Concentrated Platelet Rich Plasma System, Platelet Rich Plasma
Device · Drug
Lead sponsor
Matthew Pingree
Other
Eligibility
22 Years to 70 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 29, 2026, 8:42 AM EDT
Recruiting Phase 4 Interventional

Endogenous Opioid Response to Injections

NCT06666621
View directory record Official record
Conditions
Low Back Pain, Zygapophyseal Joint Arthritis
Interventions
Normal saline infusion, Naloxone infusion
Drug
Lead sponsor
Middle Tennessee Research Institute
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Sep 29, 2026, 8:42 AM EDT
Recruiting No phase listed Observational

MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine

NCT01788410
View directory record Official record
Conditions
Facet Joints; Degeneration, Neuropathy, Neuralgia
Interventions
Cryoablation under image guidance, MRI Seednet Cryotherapy System (Galil Medical)
Procedure · Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2030
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 7, 2023 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Cervical Facet Joint Nerve Blocks

NCT00332722
View directory record Official record
Conditions
Neck Pain
Interventions
Cervical facet joint nerve blocks
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 30, 2013 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Using MRI Scans to Evaluate Spinal Manipulation

NCT00070902
View directory record Official record
Conditions
Lower Back Pain
Interventions
Lumbar side-posture spinal adjusting
Procedure
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
21 Years to 29 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2002
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 29, 2026, 8:42 AM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 29, 2026, 8:42 AM EDT
Completed No phase listed Observational

Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes

NCT05450679
View directory record Official record
Conditions
Cervical Facet Joint Pain, Chronic Pain, Neck Pain
Interventions
Cervical Radiofrequency Ablation (RFA)
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 13, 2026 · Synced Sep 29, 2026, 8:42 AM EDT
Not listed No phase listed Observational

Technical Description of Cooled Radiofrequency Ablation of Lumbar Medial Branches for the Treatment of Lumbar Facet Pain

NCT01590004
View directory record Official record
Conditions
Lumbar Facet Joint Pain
Interventions
Not listed
Lead sponsor
Mehul Desai
Industry
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Edina, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Sep 29, 2026, 8:42 AM EDT
Not listed No phase listed Observational

Injections of FloGraft Therapy, Autologous Stem Cells, or Platelet Rich Plasma for the Treatment of Degenerative Joint Pain

NCT01978639
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis
Interventions
Not listed
Lead sponsor
Arizona Pain Specialists
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2014
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional

Medial Branch Blocks vs. Intra-articular Injections: Randomized, Controlled Study

NCT02002429
View directory record Official record
Conditions
Lumbar Facet Joint Pain, Low Back Pain
Interventions
Intra-articular injection, Medial branch block, Saline injection
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Baltimore, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 11, 2018 · Synced Sep 29, 2026, 8:42 AM EDT
Recruiting Not applicable Interventional

Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

NCT06965452
View directory record Official record
Conditions
Facet Joint Arthropathy, Pain, Osteoarthritis
Interventions
Spinal angiography and embolization/ Embozene Microspheres
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Lumbar Facet Joint Nerve Blocks

NCT00355914
View directory record Official record
Conditions
Low Back Pain
Interventions
Lumbar Facet Joint Nerve Block
Procedure
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 25, 2013 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional Results available

FDG PET/MRI Evaluation of Facet Joint Pain

NCT02921490
View directory record Official record
Conditions
Low Back Pain
Interventions
FDG PET/MR examination.
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
50 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Sep 29, 2026, 8:42 AM EDT
Completed No phase listed Observational

Cortisone Shots for Neck Pain

NCT03534531
View directory record Official record
Conditions
Neck Pain, Cervicalgia, Facet Joint Pain
Interventions
Intra-articular cervical zygapophyseal joint injection
Procedure
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
3
States / cities
Palo Alto, California • Redwood City, California • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 2, 2024 · Synced Sep 29, 2026, 8:42 AM EDT
Suspended Not applicable Interventional

PNS vs RFA for Facet Joint Pain

NCT05952518
View directory record Official record
Conditions
Facet Joint Pain
Interventions
Sprint PNS system, Radiofrequency Ablation
Device · Procedure
Lead sponsor
Penn State University
Other
Eligibility
18 Years to 80 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Sep 29, 2026, 8:42 AM EDT
Not listed No phase listed Observational

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

NCT02529566
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Odessa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional

Z-Joint Changes in Low Back Pain Following Adjusting

NCT00284063
View directory record Official record
Conditions
Mechanical Low Back Pain
Interventions
Low back adjustment and MRI, MRI
Procedure
Lead sponsor
National University of Health Sciences
Other
Eligibility
21 Years to 69 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Lombard, Illinois
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Sep 29, 2026, 8:42 AM EDT
Recruiting Not applicable Interventional

Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks

NCT05961800
View directory record Official record
Conditions
Pain, Chronic, Facet Joint Pain, Pain, Procedural, Analgesia
Interventions
Cutaneous Probe, Quantitative Sensory Testing, Computer Tasks
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 26, 2026 · Synced Sep 29, 2026, 8:42 AM EDT
Completed Not applicable Interventional Results available

Efficacy and Cost: Benefit Ratio of 0, 1, and 2 Medial Branch Blocks for Lumbar Facet Joint Radiofrequency Denervation

NCT00484159
View directory record Official record
Conditions
Low Back Pain
Interventions
Radiofrequency denervation of medial branches, 0.5% bupivacaine, 2% lidocaine, Radiofrequency denervation
Procedure · Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 25, 2011 · Synced Sep 29, 2026, 8:42 AM EDT