Independent directory Public ClinicalTrials.gov records United States
Clear filters
ClinicalTrials.gov public records Last synced Jul 22, 2026, 3:56 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 123 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Conditions
Wrinkle, Lax Skin, Lines Skin
Interventions
Thermage FLX
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
30 Years to 60 Years
Enrollment
164 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
New York, New York
Completed Not applicable Interventional Accepts healthy volunteers

Straberi Epistamp Needling Treatment For Skin Rejuvenation

NCT04742803
Conditions
Wrinkle, Elastic Skin, Collagen Degeneration
Interventions
Straberi Epistamp Microneedling Treatment
Device
Lead sponsor
Universal Skincare Institute
Other
Eligibility
21 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
New York, New York
Conditions
Skin Wrinkling
Interventions
Emervel Deep Lidocaine, Juvederm Ultra Plus
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years and older
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
11
States / cities
Los Angeles, California • San Francisco, California • New Haven, Connecticut + 8 more
Conditions
Lipoatrophy, Aging, Wrinkles
Interventions
SVF
Biological
Lead sponsor
Antria
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Greensburg, Pennsylvania
Conditions
Lax Skin, Improve Facial Wrinkles
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Diego, California
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles

NCT07222176
Conditions
Periocular Fine Wrinkles
Interventions
Split-Face Tixel Treatment With and Without Topical Peptide-Based Cosmeceutical (P-TIOX)
Combination Product
Lead sponsor
Main Line Center for Laser Surgery
Other
Eligibility
30 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Ardmore, Pennsylvania
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Cryo-Touch II for the Treatment of Wrinkles

NCT01167140
Conditions
Facial Wrinkles
Interventions
Cryo-Touch II
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
30 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Redwood City, California
Conditions
Facial Photo Damage, Periocular Fine Wrinkles, Perioral Fine Wrinkles
Interventions
Obagi New-Derm System, Standard of Care
Other
Lead sponsor
The Plastic Surgery Foundation
Other
Eligibility
18 Years to 65 Years · Female only
U.S. locations
9
States / cities
Oxnard, California • Rancho Santa Margarita, California • Greeley, Colorado + 6 more
Conditions
Wrinkles
Interventions
Not listed
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
35 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
2
States / cities
La Jolla, California • San Francisco, California
Conditions
Wrinkle, Photoaging, Fine Lines
Interventions
Gentle Cleansing Lotion, Revision Skincare, Aveeno Face Milk SPF 40+
Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Richardson, Texas
Conditions
Wrinkle, Facial and Neck Skin Laxity
Interventions
micro-excisional skin removal with coring needle
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
40 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
6
States / cities
Sacramento, California • Miami, Florida • Chestnut Hill, Massachusetts + 3 more
Conditions
Wrinkle
Interventions
BTL-785-2, No Treatment
Device · Other
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years to 70 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Hackensack, New Jersey
Conditions
Upper Facial Lines
Interventions
BOTOX
Drug
Lead sponsor
AbbVie
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
7
States / cities
Birmingham, Alabama • San Francisco, California • Vista, California + 4 more
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Cryo-Touch III Refinement Study Investigational Plan

NCT01379365
Conditions
Facial Wrinkles, Skin Aging
Interventions
Cryo-Touch III
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
30 Years to 70 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Redwood City, California
Conditions
Laxity; Skin
Interventions
MCD
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
5
States / cities
Sacramento, California • Miami, Florida • New York, New York + 2 more
Conditions
Forehead Rhytides, Glabellar Rhytides
Interventions
OnabotulinumtoxinA, Normal Saline
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
421 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
9
States / cities
Birmingham, Alabama • Glendale, Arizona • Santa Monica, California + 6 more
Conditions
Wrinkle
Interventions
Venus Aime
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years to 75 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Charlotte, North Carolina
Conditions
Wrinkle
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Global Aesthetics LLC
Other
Eligibility
20 Years to 65 Years
Enrollment
500 participants
Timeline
2024 – 2027
U.S. locations
2
States / cities
Cisco, Texas • Lubbock, Texas
Conditions
Wrinkle
Interventions
Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Santa Rosa Beach, Florida
Completed Phase 4 Interventional Results available

The Treatment of Glabellar Frown Lines

NCT02096081
Conditions
Glabellar Frown Lines
Interventions
IncobotulinumtoxinA, OnabotulinumtoxinA
Drug
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
10
States / cities
Los Angeles, California • Sacramento, California • Santa Monica, California + 6 more
Conditions
Wrinkle
Interventions
BTL-785-7 Treatment
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
21 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Completed Not applicable Interventional Accepts healthy volunteers

Device for Improving Skin Quality and Texture on the Face and Neck

NCT06645366
Conditions
Wrinkle, Pigmentation, Skin Laxity, Skin Scarring
Interventions
Treatment with BTL-785F
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Greenwood Village, Colorado • Chevy Chase, Maryland • Birmingham, Michigan
Conditions
Rhytides
Interventions
PrabotulinumtoxinA-Xvfs, OnabotulinumtoxinA
Drug
Lead sponsor
Lupo Center for Aesthetic and General Dermatology
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
New Orleans, Louisiana
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles

NCT03831477
Conditions
Rhytides, Wrinkle
Interventions
Venus Viva
Device
Lead sponsor
Venus Concept
Industry
Eligibility
22 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York