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Showing 1–24 of 77 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fontan Clear all
Completed Not applicable Interventional

Enhanced External Counterpulsation in Patients With Fontan Circulation

NCT04956952
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
EECP
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Jul 21, 2026, 6:04 PM EDT
Terminated Not applicable Interventional Results available

Perioperative Treprostinil in Pediatric Patients Undergoing the Fontan Operation

NCT02498444
View directory record Official record
Conditions
Single Ventricle
Interventions
Treprostinil
Drug
Lead sponsor
Stanford University
Other
Eligibility
1 Year to 18 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 30, 2022 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational

The Effect of Fontan Fenestration Closure on Hepatic Stiffness

NCT03481985
View directory record Official record
Conditions
Single-ventricle, Hepatic Congestion
Interventions
Fenestration status
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
Not listed
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 18, 2023 · Synced Jul 21, 2026, 6:04 PM EDT
Terminated Phase 4 Interventional Results available

Aspirin as a Novel Anti-Inflammatory Modality in the Fontan Patients

NCT02966002
View directory record Official record
Conditions
Fontan Procedure
Interventions
Aspirin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 17, 2018 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 1Phase 2 Interventional

Fibrosis and the Fontan

NCT04901975
View directory record Official record
Conditions
Single-ventricle
Interventions
Spironolactone
Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Year to 6 Years
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Not applicable Interventional

Re-Energize Fontan

NCT04195451
View directory record Official record
Conditions
Single-ventricle
Interventions
Live-Video-Supervised Exercise Intervention, Usual Care then Live-Video Supervised Exercise Intervention
Other
Lead sponsor
Stanford University
Other
Eligibility
8 Years to 19 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 3 Interventional Results available

The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease

NCT00480740
View directory record Official record
Conditions
Cardiac Transplant, Patent Ductus Arterious, Atrial Septal Defect, Bidirectional Cavopulmonary Anastomosis
Interventions
Dexmedetomidine
Drug
Lead sponsor
Children's National Research Institute
Other
Eligibility
Up to 18 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jun 25, 2015 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Not applicable Interventional

Fontan Physiology Ventilation Strategy

NCT04672538
View directory record Official record
Conditions
Anesthesia, Congenital Heart Disease
Interventions
Low Vt protocol, High Vt protocol
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Jul 21, 2026, 6:04 PM EDT
Terminated Phase 3 Interventional Results available

An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients.

NCT03775421
View directory record Official record
Conditions
Congenital Heart Disease With Fontan Circulation
Interventions
macitentan 10 mg
Drug
Lead sponsor
Actelion
Industry
Eligibility
12 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Boston, Massachusetts • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Mar 6, 2023 · Synced Jul 21, 2026, 6:04 PM EDT
Withdrawn Phase 3 Interventional

Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients

NCT01607983
View directory record Official record
Conditions
Congenital Heart Disease, Fontan
Interventions
inhaled nitric oxide
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
4 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cerebral Anatomy, Hemodynamics and Metabolism

NCT02919956
View directory record Official record
Conditions
Hypoplastic Left Heart Syndrome
Interventions
Magnetic Resonance Imaging, Neurodevelopmental Testing
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
3 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Jul 21, 2026, 6:04 PM EDT
Enrolling by invitation Phase 4 Interventional

The Fontan Dapagliflozin Pilot Study

NCT05741658
View directory record Official record
Conditions
Heart Failure
Interventions
Dapagliflozin 10mg Tab
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational

Ocular and Vision Problems in Patients After Fontan Operation

NCT03170778
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Use of Vasopressin Following the Fontan Operation

NCT02975999
View directory record Official record
Conditions
Pleural Effusion, Single-ventricle
Interventions
Vasopressin, Normal Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Months to 7 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Jul 21, 2026, 6:04 PM EDT
Terminated No phase listed Observational

Pulmonary Resistance in Fontan Who Have Undergone Heart Transplantation

NCT00268047
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 21 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 5, 2011 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational

Fontan Imaging Biomarkers (FIB) Study

NCT03119090
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Jul 21, 2026, 6:04 PM EDT
Recruiting No phase listed Observational

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

NCT06932081
View directory record Official record
Conditions
Adult Congenital Heart Disease, Congenital Heart Disease, Systemic Right Ventricle, Transposition of the Great Arteries, Congenitally Corrected Transposition of the Great Arteries, Fontan, Single Ventricle, Tetralogy of Fallot (TOF)
Interventions
SGLT2 inhibitors
Drug
Lead sponsor
Leiden University Medical Center
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
3
States / cities
Baltimore, Maryland • Grand Rapids, Michigan • New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents

NCT02201342
View directory record Official record
Conditions
Single Ventricle Heart Disease After Fontan Surgery
Interventions
Udenafil
Drug
Lead sponsor
Mezzion Pharma Co. Ltd
Industry
Eligibility
14 Years to 18 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
5
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational

Biomarker Study for Heart Failure in Children With Single Ventricle Physiology

NCT00571233
View directory record Official record
Conditions
Tricuspid Atresia, Hypoplastic Left Heart Syndrome, Unbalanced AV Canal
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
1 Month to 6 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 2 Interventional Results available

Nitrate Effect on Exercise Capacitance

NCT04297241
View directory record Official record
Conditions
Fontan
Interventions
Isosorbide Dinitrate
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
9 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 21, 2021 · Synced Jul 21, 2026, 6:04 PM EDT
Terminated Phase 4 Interventional Results available

The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease

NCT01971593
View directory record Official record
Conditions
Tetralogy of Fallot, Transposition of the Great Vessels With an Arterial Switch, Single Ventricle With a Fontan Palliation
Interventions
Eplerenone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 3, 2018 · Synced Jul 21, 2026, 6:04 PM EDT
Completed No phase listed Observational

Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology

NCT01563757
View directory record Official record
Conditions
Fontan Physiology Patients With PB or PLE, Fontan Physiology Patients Without PB or PLE
Interventions
Not listed
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
6 Months and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 28, 2013 · Synced Jul 21, 2026, 6:04 PM EDT
Completed Phase 4 Interventional Results available

TRPV2 Agonists in the Fontan Circulation

NCT03965351
View directory record Official record
Conditions
Fontan
Interventions
Probenecid, Placebo
Drug · Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 8, 2021 · Synced Jul 21, 2026, 6:04 PM EDT
Withdrawn Not applicable Interventional

The Destination Therapy Evaluation for Failing Fontan Study

NCT01149603
View directory record Official record
Conditions
Failing Fontan Physiology, Failing Fontan, Single-ventricle, Single-ventricle Fontan, Single-ventricle Physiology
Interventions
HeartMate II Ventricular Assist Device
Device
Lead sponsor
Timothy Icenogle, MD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Sep 20, 2017 · Synced Jul 21, 2026, 6:04 PM EDT