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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Frailty Clear all
Recruiting Not applicable Interventional

Structured Program of Exercise for Recipients of Kidney Transplantation

NCT04954690
View directory record Official record
Conditions
Kidney Transplant; Complications, Dialysis; Complications, Physical Disability, Frailty Syndrome
Interventions
Structured Program of exercise for Recipients of Kidney Transplantation (WC), Structured Program of exercise for Recipients of Kidney Transplantation (WC + CG), Usual Care
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
50 Years and older
Enrollment
136 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2029
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Does Pulmonary Rehabilitation Improve Frailty?

NCT02512874
View directory record Official record
Conditions
Disease, Pulmonary
Interventions
Pulmonary Rehabilitation, Dynamometer, DEXA, Gait Speed Test, Activity Monitor, Questionnaires
Other · Device · Radiation
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 22, 2020 · Synced Sep 5, 2026, 5:57 AM EDT
Suspended Phase 2 Interventional

Reducing Frailty for Older Cancer Survivors Using Supplements II

NCT06068543
View directory record Official record
Conditions
Frailty, Inflammation
Interventions
Epigallocatechin-3-Gallate (EGCG), Microcrystalline cellulose (MCC), Ascorbic Acid (Vitamin C)
Drug · Dietary Supplement
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Recruiting Not applicable Interventional

Improve Outcomes for Older Allogeneic Transplant Recipients

NCT05612789
View directory record Official record
Conditions
Allogeneic Transplantation
Interventions
Exercise Program (Cohort A Prehab), Exercise Program (Cohort B Rehab)
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
60 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Sep 5, 2026, 5:57 AM EDT
Completed No phase listed Observational

Comprehensive Frailty Assessment

NCT02033928
View directory record Official record
Conditions
Myeloma, Multiple, Paraproteinemias, Hematologic Neoplasms
Interventions
Not listed
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 27, 2018 · Synced Sep 5, 2026, 5:57 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Functional Capacity in Older Adults With Short Session High Intensity Interval Training

NCT03750006
View directory record Official record
Conditions
Frailty
Interventions
Short session HIIT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years to 85 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Sep 5, 2026, 5:57 AM EDT
Completed No phase listed Observational

A Comparative Study of Subjects Past Their Final Follow-ON Visit

NCT03071835
View directory record Official record
Conditions
Cardiomyopathies, Heart Diseases, Aging Frailty
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Phase 1 Interventional

Telephone Call From Acute Care Physicians to Long Term Care Physicians: Impact on Transitional Care of Elderly Patients

NCT00281749
View directory record Official record
Conditions
Alzheimer Disease, Parkinson Disease, Dysphagia
Interventions
TELEPHONE CALL
Procedure
Lead sponsor
Maimonides Medical Center
Other
Eligibility
65 Years and older
Timeline
Ends 2006
U.S. locations
2
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Aug 17, 2011 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Phase 2 Interventional

HORMA: Hormonal Regulators of Muscle and Metabolism in Aging

NCT00183040
View directory record Official record
Conditions
Sarcopenia, Muscle Weakness, Frailty
Interventions
Topical testosterone, Recombinant human growth hormone
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
65 Years to 90 Years · Male only
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
2
States / cities
Boston, Massachusetts • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 1, 2009 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Strength on Wheels: A Meal Delivery and Exercise Intervention for Homebound Older Adults

NCT04087343
View directory record Official record
Conditions
Frailty
Interventions
Meals plus exercise, Meals only
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
60 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Frailty in Children With Cardiac Disease

NCT02999438
View directory record Official record
Conditions
Pulmonary Hypertension, Heart Failure, Single Ventricle
Interventions
Actigraph to check activity levels at home
Device
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
8 Years to 18 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Active, not recruiting Not applicable Interventional

The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail

NCT07167277
View directory record Official record
Conditions
Pre-frail, Pre-Frail Older Adults, Cognition, Physical Function, Dietary Intake Assessment, MRI
Interventions
Whey Protein, Placebo
Dietary Supplement
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Recruiting Not applicable Interventional

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

NCT05725928
View directory record Official record
Conditions
Mobility Limitation, Frailty, Hospital Acquired Condition, Weakness, Muscle
Interventions
Mobility technician
Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
65 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
5
States / cities
Springfield, Massachusetts • Cleveland, Ohio • Garfield Heights, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure

NCT06576297
View directory record Official record
Conditions
Aging, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Frailty, Physical Function, Quality of Life
Interventions
Inspiratory Muscle Training (IMT), Standard of Care
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
70 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Not applicable Interventional Results available

Boston ARCH 4F Intervention to Reduce Fall Risk in People With HIV and Alcohol Use

NCT04804579
View directory record Official record
Conditions
HIV Infection, Alcohol Consumption, Falls, Accidental, Falls
Interventions
Fall Prevention Intervention
Behavioral
Lead sponsor
Boston University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Pilot-testing the Effect of Magnetic Mitohormesis Therapy for Treating Frailty in Older Adults

NCT05930470
View directory record Official record
Conditions
Frailty
Interventions
Magnetic Mitohormesis Therapy
Other
Lead sponsor
Auburn University
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 4, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Not applicable Interventional

Psychosocial Stress and Aging in HIV

NCT02965469
View directory record Official record
Conditions
HIV, Aging, Stress, Psychological, Frailty
Interventions
Breathe2Relax
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Sep 5, 2026, 5:57 AM EDT
Completed No phase listed Observational

Frailty: Prevalence and Response to Left Ventricular Assist Device Therapy in Older Heart Failure Patients

NCT02156583
View directory record Official record
Conditions
Systolic Heart Failure
Interventions
Not listed
Lead sponsor
Thomas Jefferson University
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Phase 2 Interventional

Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty

NCT05283486
View directory record Official record
Conditions
Sarcopenia, Frailty, Aging
Interventions
MYMD-1 600MG, MYMD-1 750mg, MYMD-1 900mg, MYMD-1 1050mg, placebo 600mg, placebo 750mg, placebo 900mg, placebo 1050mg
Drug
Lead sponsor
TNF Pharmaceuticals, Inc.
Industry
Eligibility
65 Years to 99 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
3
States / cities
Clearwater, Florida • Tampa, Florida • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 29, 2023 · Synced Sep 5, 2026, 5:57 AM EDT
Suspended Phase 2 Interventional

Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease

NCT03325322
View directory record Official record
Conditions
Chronic Kidney Diseases, Diabetes Mellitus, Diabetic Nephropathies
Interventions
Fisetin, Placebo oral capsule
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
40 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Completed Phase 3 Interventional Results available

PREPARE (A5361s) Ancillary Study of REPRIEVE (A5332)

NCT03070223
View directory record Official record
Conditions
HIV-1 Infection
Interventions
Pitavastatin, Placebos
Drug
Lead sponsor
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Network
Eligibility
40 Years to 75 Years
Enrollment
602 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
30
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 22 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2024 · Synced Sep 5, 2026, 5:57 AM EDT
Recruiting No phase listed Observational

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

NCT04717869
View directory record Official record
Conditions
Frailty, Sarcopenia
Interventions
Ultrasound, Biomarker Analysis, Frailty Index
Diagnostic Test · Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 5, 2026, 5:57 AM EDT
Withdrawn Not applicable Interventional

Cardiac Rehab for Advanced Heart Failure-LVAD Candidates

NCT03132441
View directory record Official record
Conditions
Heart Failure
Interventions
Strength Training for Frailty
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 25, 2018 · Synced Sep 5, 2026, 5:57 AM EDT
Terminated Not applicable Interventional

A Pilot Study of High Intensity Walking in Older Adults in the Pre-operative Period

NCT04241419
View directory record Official record
Conditions
Frailty
Interventions
High Intensity Walking
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
60 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 22, 2024 · Synced Sep 5, 2026, 5:57 AM EDT