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ClinicalTrials.gov public records Last synced May 22, 2026, 1:38 AM EDT

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Showing 1–6 of 6 matching trials from the live ClinicalTrials.gov search.

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Filters: Condition: Functional Constipation (FC) Clear all

Completed Phase 2 Interventional Results available

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)

NCT02559570

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Conditions: Functional Constipation in Children Ages 6-17 Years
Interventions: Placebo, LIN Dose A, LIN Dose B, LIN Dose C, LIN 145 µg; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 6 Years to 17 Years

Enrollment: 173 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 60
States / cities: Hot Springs, Arkansas • Little Rock, Arkansas • Anaheim, California + 51 more

Source: ClinicalTrials.gov public record

Updated Jun 18, 2019 · Synced May 22, 2026, 1:38 AM EDT

Completed Phase 2 Interventional

A Phase 2 Study to Evaluate Pharmacodynamics of YKP10811 in Patients With Chronic or Functional Constipation

NCT01523184

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Conditions: Chronic Constipation, Functional Constipation
Interventions: Placebo Capsule, YKP10811 Drug Product Capsule; Drug
Lead sponsor: SK Life Science, Inc.; Industry
Eligibility: 18 Years to 65 Years

Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Source: ClinicalTrials.gov public record

Updated Jul 3, 2014 · Synced May 22, 2026, 1:38 AM EDT

Completed Phase 3 Interventional Results available

A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation

NCT05652205

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Conditions: Functional Constipation (FC), Chronic Idiopathic Constipation (CIC)
Interventions: Placebo for Linaclotide, Linaclotide; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 2 Years to 5 Years

Enrollment: 123 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 38
States / cities: Foley, Alabama • Phoenix, Arizona • Hot Springs, Arkansas + 33 more

Source: ClinicalTrials.gov public record

Updated May 13, 2026 · Synced May 22, 2026, 1:38 AM EDT

Completed Phase 3 Interventional Results available

Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)

NCT04026113

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Conditions: Functional Constipation, Irritable Bowel Syndrome With Constipation
Interventions: Linaclotide, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 6 Years to 17 Years

Enrollment: 438 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 79
States / cities: Birmingham, Alabama • Foley, Alabama • Saraland, Alabama + 62 more

Source: ClinicalTrials.gov public record

Updated Nov 25, 2024 · Synced May 22, 2026, 1:38 AM EDT

Completed Phase 3 Interventional Results available

Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C

NCT04166058

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Conditions: Irritable Bowel Syndrome With Constipation, Functional Constipation
Interventions: Irritable Bowel Syndrome with Constipation (IBS-C) participants (LIN-MD-63 and LIN-MD-64 completers), Functional Constipation (FC) participants (LIN-MD-62 and LIN-MD-64 completers); Drug
Lead sponsor: AbbVie; Industry
Eligibility: 6 Years to 18 Years

Enrollment: 381 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2025
U.S. locations: 65
States / cities: Birmingham, Alabama • Foley, Alabama • Saraland, Alabama + 50 more

Source: ClinicalTrials.gov public record

Updated Jan 5, 2026 · Synced May 22, 2026, 1:38 AM EDT

Completed Phase 2 Interventional Results available

A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide

NCT05760313

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Conditions: Functional Constipation
Interventions: Linaclotide, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 6 Months to 23 Months

Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 18
States / cities: Phoenix, Arizona • Hot Springs, Arkansas • Anaheim, California + 14 more

Source: ClinicalTrials.gov public record

Updated Jan 5, 2026 · Synced May 22, 2026, 1:38 AM EDT