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ClinicalTrials.gov public records Last synced Nov 6, 2026, 7:21 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Heart Disease Structural Disorder Clear all

Conditions: Atrial Fibrillation, Cardiovascular Diseases, Arrhythmia, Valvular Disease
Interventions: Risk-Based Assessment for Cardiac Dysfunction; Device
Lead sponsor: Northwestern University; Other
Eligibility: 40 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cardiovascular Disease
Interventions: Vitamin D3 + fish oil/fish oil placebo, Vitamin D3 placebo + fish oil/fish oil placebo; Dietary Supplement
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 50 Years and older
Enrollment: 1,025 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Cardiac Disease
Interventions: AI-Flex; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 85 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale, PIVSD - Post Infarct Muscular Ventricular Septal Defect, Valvular Heart Disease
Interventions: Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: Not listed
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2039
U.S. locations: 13
States / cities: Los Angeles, California • Washington D.C., District of Columbia • Miami, Florida + 9 more

Conditions: Mitral Regurgitation (MR)
Interventions: Capstan Compass Robotic System for Transcatheter Mitral Valve Replacement; Device
Lead sponsor: Capstan Medical; Industry
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 3
States / cities: San Francisco, California • Cincinnati, Ohio • Nashville, Tennessee

Conditions: Obesity, Metabolic Dysfunction-associated Steatotic Liver Disease
Interventions: Survodutide, Placebo matching survodutide; Combination Product
Lead sponsor: Boehringer Ingelheim; Industry
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 15
States / cities: Peoria, Arizona • Los Angeles, California • Oxnard, California + 12 more

Conditions: Atrial Fibrillation, Structural Heart Disease
Interventions: Zio Patch Monitor, Echocardiogram; Device
Lead sponsor: Tempus AI; Industry
Eligibility: 40 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 3
States / cities: Grand Rapids, Michigan • Cincinnati, Ohio • Danville, Pennsylvania

Conditions: Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 80 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2030
U.S. locations: 2
States / cities: Newark, Delaware • Baltimore, Maryland

Conditions: Chronic Hemodialysis (ESRD)
Interventions: Hydralazine/Isorsorbide Dinitrate, Placebo; Drug
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Heart Failure, Ischemic Cardiomyopathy
Interventions: Not listed
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2006
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Aortic Valve Stenosis, Heart Valve Diseases, Aortic Valve Disease, Heart Disease Structural Disorder
Interventions: Navitor Transcatheter Aortic Valve Implantation (TAVI) System, Any Commercially Available Transcatheter Aortic Valve (CAV) System; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 1,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2036
U.S. locations: 74
States / cities: Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 65 more

Conditions: Isolated Aortic Stenosis, Mitral Regurgitation
Interventions: ©VoqX stethoscope; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Postpartum Depression (PPD), Cardiac Event
Interventions: LHMoms Intervention, No intervention; Behavioral · Other
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 4
States / cities: Brooklyn, New York • Jamaica, New York • New York, New York

Conditions: Tricuspid Regurgitation, Heart Failure, Structural Heart Disease, Interventional Cardiology
Interventions: Not listed
Lead sponsor: Columbia University; Other
Eligibility: 18 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Cardiomyopathy, Hypertrophic
Interventions: PET Scan; Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Atrial Fibrillation, Stroke, Valve Disease, Heart, Atrial Septal Defect, Patent Foramen Ovale, Mitral Valve Disease, Tricuspid Valve Disease, Aortic Valve Disease
Interventions: ICE Image guidance; Device
Lead sponsor: Philips Clinical & Medical Affairs Global; Industry
Eligibility: 18 Years and older
Enrollment: 155 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 5
States / cities: Aurora, Colorado • Chicago, Illinois • Boston, Massachusetts + 2 more

Conditions: Structural Heart Disease
Interventions: Not listed
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2032
U.S. locations: 2
States / cities: Atlanta, Georgia • Bethesda, Maryland

Conditions: Congenital Heart Disease
Interventions: Entresto Pill, Placebo; Drug · Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Valvular Heart Disease, Aortic Valve Failure
Interventions: TELLTALE BASILICA procedure; Device
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 21 Years to 109 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 10
States / cities: San Francisco, California • Fort Collins, Colorado • Washington D.C., District of Columbia + 7 more

Conditions: Cardiac Disease
Interventions: AI-ECG (artificial intelligence-enabled electrocardiogram), Focus Screening (focused cardiac ultrasonography); Diagnostic Test
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 2,705 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Mucopolysaccharidoses, Carotid Disease, Cardiac Disease, Inflammation
Interventions: Carotid ultrasonography, Echocardiography, transthoracic, Venipuncture; Diagnostic Test · Procedure
Lead sponsor: Children's Hospital of Orange County; Other
Eligibility: Not listed
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Orange, California

Conditions: Structural Heart Disease
Interventions: Transesophageal Echocardiography/angiography (TEE/Angio); Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Pulmonary Artery Hypertension, Congenital Heart Disease, Structural Heart Disease
Interventions: MRI Heart guidewire catheterization; Diagnostic Test
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
Interventions: contrast-enhanced magnetic resonance imaging; Procedure
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years to 120 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Search by objective public record fields.

NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

Impact of Vitamin D Supplementation on Cardiac Structure and Function

A Study of a Multi-Modal Sensor Patch for Real-Time Physiological Monitoring and Inference

Abbott Structural Heart Device Registry

Early Feasibility Study of the Capstan Medical TMVR System

ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease

Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease

Left Ventricular Structural Predictors of Sudden Cardiac Death

Safety and Cardiovascular Efficacy of Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD

Optima Coronary Artery Disease (CAD) (Optimal Mechanical Evaluation)

ENVISION IDE Trial: Safety and Effectiveness of NAVITOR in Transcatheter Aortic Valve Implantation

A Study to Evaluate a Computerized Stethoscope Called ©Voqx to Diagnose Heart Disease

Living Healthy for Moms RCT

Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study

The Impact of Exercise-Induced Cardiac Remodeling on Myocardial Efficiency

Philips Intracardiac Echocardiography (ICE) Clinical Registry

NHLBI-Emory Advanced Cardiac CT Reconstruction

Effect of Sacubitril-Valsartan on Cardiac Structure and Function

NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial

A Study of Electrocardiogram and Focused Cardiac Ultrasound for Enhanced Cardiac Disease Screening

Cardiovascular Structure and Function in the Mucopolysaccharidoses

TEE/Angio Fusion Study

Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive Guidewires

Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin