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ClinicalTrials.gov public records Last synced Jul 22, 2026, 11:41 PM EDT

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Showing 1–24 of 41 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hiatal Hernia Clear all
Completed No phase listed Observational Results available

Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH

NCT03735862
View directory record Official record
Conditions
Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux, GERD
Interventions
Hepatic derived surgical matrix
Biological
Lead sponsor
Miromatrix Medical Inc.
Industry
Eligibility
Not listed
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Lorton, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 30, 2019 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair

NCT06444347
View directory record Official record
Conditions
Hiatal Hernia
Interventions
Biosynthetic Mesh, Hiatal Hernia Repair
Device · Procedure
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2030
U.S. locations
6
States / cities
Los Angeles, California • New Orleans, Louisiana • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 22, 2026, 11:41 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Fundoplication in Laparoscopic PEH Repair Based on FLIP

NCT05807763
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
Laparoscopic paraesophageal hernia repair without fundoplication
Procedure
Lead sponsor
The Foundation for Surgical Innovation and Education
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
2
States / cities
Evanston, Illinois • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Jul 22, 2026, 11:41 PM EDT
Not listed No phase listed Observational

Registry of Outcomes From AntiReflux Surgery

NCT02923362
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions
Laparoscopic Fundoplication, LINX Antireflux
Procedure · Device
Lead sponsor
The Heartburn Foundation
Other
Eligibility
21 Years and older
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
19
States / cities
Birmingham, Alabama • Mobile, Alabama • Heber Springs, Arkansas + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2023 · Synced Jul 22, 2026, 11:41 PM EDT
Completed No phase listed Observational

Use of Strattice Mesh in Paraesophageal Hernia Surgery

NCT01678157
View directory record Official record
Conditions
Esophageal Hernia, Hernia, Esophageal, Hernia, Paraesophageal, Hiatal Hernia, Paraesophageal Hiatal Hernia, Sliding Esophageal Hernia, Sliding Hiatal Hernia
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

Mesh Vs Pledgets for Repair of Paraesophageal Hernia

NCT05974722
View directory record Official record
Conditions
Paraesophageal Hernia, GERD
Interventions
OviTex Mesh, Pledgeted sutures
Device · Other
Lead sponsor
David Krpata
Other
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jul 22, 2026, 11:41 PM EDT
Not listed No phase listed Observational

Study of Paraesophageal Hernia Repair With Small Intestine Submucosa

NCT00786084
View directory record Official record
Conditions
Hiatal Hernia, Paraesophageal Hernia
Interventions
Not listed
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
4
States / cities
St Louis, Missouri • Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 30, 2009 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Not applicable Interventional Results available

Miromatrix Biological Mesh for Hiatal Hernia Repair

NCT02436681
View directory record Official record
Conditions
Hiatal Hernia
Interventions
MIROMESH
Device
Lead sponsor
Miromatrix Medical Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
6
States / cities
Lexington, Kentucky • Long Branch, New Jersey • Charlotte, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2019 · Synced Jul 22, 2026, 11:41 PM EDT
Completed No phase listed Observational

ACELL Mesh for Paraesophageal Hernia Repair

NCT03058731
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
Matristem, Control
Device
Lead sponsor
University of South Florida
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 27, 2019 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Postoperative Opioids in Patients Undergoing Laparoscopic Hiatal Hernia

NCT05953428
View directory record Official record
Conditions
Hiatal Hernia
Interventions
Opioid Sparing Anesthesia Protocol (OSA), Opioid Based Anesthesia Protocol (OBA)
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Randomized, Prospective Controlled Trial of Paraesophageal Hernia Repair With Small Intestinal Submucosa (SIS)

NCT00272922
View directory record Official record
Conditions
Hernia, Paraesophageal Hernia
Interventions
hernia repair
Device
Lead sponsor
Cook Group Incorporated
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 17, 2007 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting No phase listed Observational

Posterior Rectus Sheath Hiatal Augmentation in Paraesophageal Hernia Repair

NCT06551077
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
POSTERIOR RECTUS SHEATH HIATAL AUGMENTATION (PORSHA)
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

Ovitex in Paraesophageal and Large Hiatal Hernia Repair

NCT06193551
View directory record Official record
Conditions
Paraesophageal Hernia, Large Hiatal Hernia
Interventions
Ovitex LPR
Device
Lead sponsor
Foregut Research Foundation
Other
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
Lone Tree, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Not yet recruiting Not applicable Interventional

Antireflux Surgery Without Preoperative Esophageal Manometry

NCT07659080
View directory record Official record
Conditions
GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia, Gastroesophageal Reflux
Interventions
Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
Procedure
Lead sponsor
McMaster University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Improving Pain Control in Paraesophageal Hernia Repair: Intravenous Lidocaine Versus Placebo

NCT04096170
View directory record Official record
Conditions
Hernia, Paraesophageal
Interventions
IV lidocaine, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

Evaluating Clinical Hiatal Hernia Outcomes Using OviTex®

NCT07070115
View directory record Official record
Conditions
Hiatal Hernia
Interventions
OviTex Reinforced Tissue Matrix
Device
Lead sponsor
Tela Bio Inc
Industry
Eligibility
22 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
2
States / cities
Mobile, Alabama • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Terminated No phase listed Observational

LINX Reflux Management System or Fundoplication Clinical Study in Patients With Hiatal Hernia >3 cm

NCT04695171
View directory record Official record
Conditions
Hiatal Hernia Large, Gastro Esophageal Reflux, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Reflux, Gastroesophageal, Reflux Acid
Interventions
LINX Reflux Management System, Fundoplication
Device · Procedure
Lead sponsor
Foregut Research Foundation
Other
Eligibility
21 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
6
States / cities
Los Angeles, California • Lone Tree, Colorado • Coral Springs, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Genetic Analysis of Congenital Diaphragmatic Disorders

NCT01243229
View directory record Official record
Conditions
Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration, Congenital Hiatal Hernia, Congenital Diaphragmatic Disorders
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
Not listed
Enrollment
305 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2021
U.S. locations
2
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 2, 2023 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Transoral Incisionless Fundoplication (TIF) Registry Study for Treatment of Gastroesophageal Reflux Disease (GERD)

NCT01118585
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Hiatal Hernia
Interventions
TIF Procedure
Procedure
Lead sponsor
EndoGastric Solutions
Industry
Eligibility
18 Years to 75 Years
Enrollment
278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
14
States / cities
Safford, Arizona • Tempe, Arizona • Englewood, Colorado + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2019 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting No phase listed Observational

Esophageal Cancer Risk Registry

NCT00260585
View directory record Official record
Conditions
Esophageal Cancer, Gastroesophageal Reflux Disease (GERD), Esophageal Diseases, Hiatal Hernia, Esophageal Achalasia
Interventions
Survey of client health, personal habits, family history, Blood specimen for non-DNA and DNA parts, Biopsy of esophageal/stomach tissue, lymph nodes, tumor, Biopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
7,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2050
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Not yet recruiting Not applicable Interventional

Low Pressure Pneumoperitoneum Using AirSeal® for Reduction in Postoperative Shoulder Pain Following Robot Assisted Hiatal Hernia Repair

NCT06737068
View directory record Official record
Conditions
Hernia, Hiatal, Pneumoperitoneum, Postoperative Pain, Shoulder Pain
Interventions
Low pressure pneumoperitoneum (8-10mmHg) with AirSeal device, Standard pressure pneumoperitoneum (13- 15 mmHg) with AirSeal device
Procedure
Lead sponsor
Riverside University Health System Medical Center
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Moreno Valley, California
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Jul 22, 2026, 11:41 PM EDT
Recruiting No phase listed Observational

Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair

NCT07197619
View directory record Official record
Conditions
Paraesophageal Hernia
Interventions
Not listed
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 80 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jul 22, 2026, 11:41 PM EDT
Not yet recruiting Not applicable Interventional

Image-Guided Herniorrhaphy Study

NCT07267494
View directory record Official record
Conditions
Hernia, Hernia Abdominal Wall, Ventral Hernia, Inguinal Hernia, Hiatal Hernia, Diastasis Recti
Interventions
Image-Guided Herniorrhaphy
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Jul 22, 2026, 11:41 PM EDT
Completed Not applicable Interventional Results available

SurgiMend Mesh at the Hiatus

NCT04282720
View directory record Official record
Conditions
Hiatal Hernia
Interventions
SurgiMend Mesh
Device
Lead sponsor
Kettering Health Network
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 22, 2026, 11:41 PM EDT