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Showing 1–24 of 98 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hydrocephalus Clear all
Recruiting Not applicable Interventional

Flow Detection in Open and Closed Shunt Valve Periods

NCT07478926
View directory record Official record
Conditions
Hydrocephalus
Interventions
Rhaeos Shunt Monitoring System
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Terminated No phase listed Observational

Prognostic Value of Aβ Imaging in NPH Prior to Shunt Placement

NCT01834625
View directory record Official record
Conditions
Normal Pressure Hydrocephalus Patients
Interventions
PET scan
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2022 · Synced Jul 21, 2026, 6:55 PM EDT
Terminated No phase listed Observational

CPT-3 in Normal Pressure Hydrocephalus

NCT03521518
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Conner's Continuous Performance Test-3
Diagnostic Test
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
8 participants
Timeline
2019 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Jul 21, 2026, 6:55 PM EDT
Terminated Not applicable Interventional

A Secondary Study Evaluating Aqueduct's Smart External Drain (SED)

NCT03471702
View directory record Official record
Conditions
Hydrocephalus, Hydrocephalus in Children, Tumor, Brain, Subarachnoid Hemorrhage
Interventions
Smart External Drain - SED
Device
Lead sponsor
Aqueduct Critical Care
Industry
Eligibility
Up to 80 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
3
States / cities
Houston, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Jul 21, 2026, 6:55 PM EDT
Completed No phase listed Observational

Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus

NCT00600795
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
CSF collection
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 3, 2017 · Synced Jul 21, 2026, 6:55 PM EDT
Recruiting Not applicable Interventional

Ultrasound (US) Guided External Ventricular Catheter Placement

NCT06253858
View directory record Official record
Conditions
Hydrocephalus
Interventions
Catheter Placement with Solopass System
Device
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Recruiting Phase 3 Interventional

HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants

NCT04177914
View directory record Official record
Conditions
Hydrocephalus
Interventions
Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
Procedure · Device
Lead sponsor
University of Utah
Other
Eligibility
1 Day to 104 Weeks
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
18
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 15 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Not yet recruiting Not applicable Interventional

Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor

NCT07679035
View directory record Official record
Conditions
Hydrocephalus
Interventions
Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Enrolling by invitation Not applicable Interventional

Non-Invasive Pressure Monitor for Neonates & Infants at Risk of Developing Hydrocephalus

NCT06310213
View directory record Official record
Conditions
Hydrocephalus in Infants
Interventions
Non-Invasive Pressure Monitor
Device
Lead sponsor
Indiana University
Other
Eligibility
0 Months to 12 Months
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Oct 7, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Completed No phase listed Observational

Establishing the Physiology of Syringomyelia

NCT00001327
View directory record Official record
Conditions
Arnold Chiari Deformity, Hydrocephalus, Syringomyelia
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1992 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 6:55 PM EDT
Completed Phase 2 Interventional

A Study Comparing Two Treatments for Infants With Hydrocephalus

NCT00652470
View directory record Official record
Conditions
Hydrocephalus
Interventions
Endoscopic Third Ventriculostomy, CSF Shunt Insertion
Procedure
Lead sponsor
The Hospital for Sick Children
Other
Eligibility
1 Day to 24 Months
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 9, 2018 · Synced Jul 21, 2026, 6:55 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics

NCT04099823
View directory record Official record
Conditions
Hydrocephalus, Alzheimer Disease
Interventions
MRI screening form, Urine pregnancy test, MR brain
Other · Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Recruiting Phase 1 Interventional

Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?

NCT05001750
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Ventriculitis, Cerebral, Hydrocephalus
Interventions
Long term (continuous) prophylactic antibiotics, 24 hours antibiotics
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Not yet recruiting Not applicable Interventional

Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic Patients

NCT06410885
View directory record Official record
Conditions
Hydrocephalus
Interventions
Thermal Anisotropy Measurement Device
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
2 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Completed No phase listed Observational

Flow Measurements in Functional CSF Shunts and Off-Shunt Locations with a Second-Generation Thermal Device

NCT06524492
View directory record Official record
Conditions
Hydrocephalus
Interventions
FlowSense
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
3
States / cities
Tampa, Florida • Chicago, Illinois • Rolling Meadows, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Active, not recruiting Not applicable Interventional

Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

NCT06498960
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
CereVasc eShunt System, VP Shunt
Device
Lead sponsor
CereVasc Inc
Industry
Eligibility
60 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2031
U.S. locations
29
States / cities
Los Angeles, California • New Haven, Connecticut • Jacksonville, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Recruiting Not applicable Interventional

Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement Device

NCT07050628
View directory record Official record
Conditions
Hydrocephalus
Interventions
wireless thermal anisotropy measurement device
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
5 Years to 21 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Jul 21, 2026, 6:55 PM EDT
Not yet recruiting No phase listed Observational

Assessment of Flow in Cerebrospinal Fluid Shunts With a Second Generation Wireless Thermal Anisotropy Measurement Device

NCT06409286
View directory record Official record
Conditions
Hydrocephalus
Interventions
Thermal Anisotropy Measurement Device
Device
Lead sponsor
Rhaeos, Inc.
Industry
Eligibility
Not listed
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Completed Not applicable Interventional Results available

A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial

NCT03350750
View directory record Official record
Conditions
Idiopathic Normal Pressure Hydrocephalus (INPH)
Interventions
programmable CSF shunt valve
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
Baltimore, Maryland • Albuquerque, New Mexico • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2022 · Synced Jul 21, 2026, 6:55 PM EDT
Completed No phase listed Observational

Magnetic Resonance Imaging (MRI) of Ventriculomegaly: Morphology and Outcome

NCT00870675
View directory record Official record
Conditions
Ventriculomegaly
Interventions
Not listed
Lead sponsor
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
NIH
Eligibility
18 Years and older · Female only
Enrollment
434 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2014 · Synced Jul 21, 2026, 6:55 PM EDT
Completed No phase listed Observational

Normal Pressure Hydrocephalus (NPH) Registry

NCT00233701
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Not listed
Lead sponsor
Codman & Shurtleff
Industry
Eligibility
18 Years and older
Enrollment
343 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
28
States / cities
Phoenix, Arizona • Los Angeles, California • Boulder, Colorado + 25 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2010 · Synced Jul 21, 2026, 6:55 PM EDT
Terminated Not applicable Interventional

Anterior Pituitary Function in Patients With Hydrocephalus

NCT00149721
View directory record Official record
Conditions
Normal Pressure Hydrocephalus
Interventions
Ventriculo-peritonal shunting
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 1, 2010 · Synced Jul 21, 2026, 6:55 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Magnetic Resonance Elastography in Hydrocephalus

NCT02230124
View directory record Official record
Conditions
Hydrocephalus
Interventions
MRE
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
45 Years to 95 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Jul 21, 2026, 6:55 PM EDT
Active, not recruiting Not applicable Interventional

Hyperfine Portable MRI in Hydrocephalus and Other Conditions Prompting Outpatient Brain Imaging

NCT04436068
View directory record Official record
Conditions
Hydrocephalus, Neurological Disorder
Interventions
Hyperfine MRI scan
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 6:55 PM EDT