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Showing 1–20 of 20 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hyperarousal Clear all
Not listed Phase 2 Interventional

Carvedilol Versus Placebo for Treatment in Post Traumatic Stress Disorder (PTSD)

NCT01221792
View directory record Official record
Conditions
Post-Traumatic Stress Disorder
Interventions
Carvedilol, Placebo
Drug
Lead sponsor
Columbia Northwest Pharmaceuticals
Industry
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
3
States / cities
San Diego, California • Lake Charles, Louisiana • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Jun 7, 2011 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cereset Research Long-Term Healthcare Worker Study

NCT05994261
View directory record Official record
Conditions
Stress, Anxiety, Autonomic Dysregulation, Acoustic Stimulation, Hyperarousal, Health Personnel
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 21, 2026, 11:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Impact of Hyperarousal on Simple and Complex Cognitive Task Performance Among Insomnia Sufferers

NCT02290405
View directory record Official record
Conditions
Insomnia, Primary Insomnia, Chronic Insomnia
Interventions
Multiple Sleep Latency Test (MSLT)
Behavioral
Lead sponsor
Jack Edinger, PhD
Other
Eligibility
21 Years to 80 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Jul 21, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Alpha Auditory Entrainment for Cognitive Enhancement and Sensory Hypersensitivity in Youth With Developmental Disorders

NCT06227780
View directory record Official record
Conditions
Fragile X Syndrome, Autism Spectrum Disorder, Autistic Disorder, Asperger Syndrome
Interventions
Alpha Auditory Entrainment, Sham
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
5 Years to 10 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 21, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional

Cereset Research Exploratory Study

NCT03777267
View directory record Official record
Conditions
Neurological Diseases or Conditions, Cardiovascular Conditions After Birth, Psychophysiologic Disorders
Interventions
Active CR
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
11 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 21, 2026, 11:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Metabolomics of Insomnia-Related Hyperarousal

NCT01957111
View directory record Official record
Conditions
Primary Insomnia
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
25 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management

NCT00855816
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Breathing training
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2014 · Synced Jul 21, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cereset Research for Caregivers

NCT05209438
View directory record Official record
Conditions
Caregivers
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 21, 2026, 11:33 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

INSIGHT: Insomnia, Nightmares, and Sympathetic Hyperactivity Intervention

NCT07288593
View directory record Official record
Conditions
Nightmare, Insomnia, PTSD, TBI, Sleep Disorder (Disorder), REM Behavior Disorder
Interventions
NightWare smartwatch configured to detect physiological signs of sympathetic activation during sleep, such as heart-rate spikes and movement patterns., Sham (No Treatment)
Device
Lead sponsor
Uniformed Services University of the Health Sciences
Federal
Eligibility
18 Years to 62 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bethesda, Maryland • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

HIRREM for Stage 1 Primary Hypertension

NCT03479697
View directory record Official record
Conditions
Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor, Autonomic Nervous System Imbalance
Interventions
HIRREM, Continued Current Care
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Phase 1 Interventional

NMDA Receptor Modulation for Hyperarousal in PTSD

NCT03166501
View directory record Official record
Conditions
Depression, Post Traumatic Stress Disorder
Interventions
Lanicemine, Placebo
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

HIRREM in Military Personnel

NCT03230890
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
HIRREM
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Jul 21, 2026, 11:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Glutamate, Hyperarousal and Restless Legs Syndrome

NCT01675323
View directory record Official record
Conditions
Restless Legs Syndrome
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

Study of the Effects of HIRREM-SOP for Insomnia

NCT03607994
View directory record Official record
Conditions
Insomnia, Sleep Deprivation
Interventions
HIRREM-SOP, NCC
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2022 · Synced Jul 21, 2026, 11:33 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Cereset Research For Chronic Nausea

NCT05229107
View directory record Official record
Conditions
Nausea, Gastroparesis, Stress, Anxiety, Hyperarousal, Quality of Life, Vomiting, Heart Rate Variability
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jul 21, 2026, 11:33 PM EDT
Withdrawn Phase 1 Interventional

Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study

NCT01754883
View directory record Official record
Conditions
Combat Posttraumatic Stess Disorder, Mild Traumatic Brain Injury
Interventions
Lithium Carbonate
Drug
Lead sponsor
VA Eastern Colorado Health Care System
Federal
Eligibility
18 Years to 50 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 6, 2016 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cereset Research In Healthcare Workers During COVID-19

NCT04682197
View directory record Official record
Conditions
Health Personnel, Stress, Anxiety, Insomnia, Hyperarousal, Corona Virus Infection, Covid19
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 21, 2026, 11:33 PM EDT
Recruiting Not applicable Interventional

A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD

NCT06925867
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder
Interventions
Frequency Filtered Music, Unfiltered Music, Cognitive Processing Therapy for PTSD
Other · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Columbus, Ohio • Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Not applicable Interventional Results available

HIRREM Hot Flashes Study

NCT03512002
View directory record Official record
Conditions
Vasomotor Symptoms, Hot Flashes, Menopause
Interventions
HIRREM, Continued Current Care
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years and older · Female only
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2023 · Synced Jul 21, 2026, 11:33 PM EDT
Completed Phase 2 Interventional

Mindfulness-Based Approaches to Insomnia

NCT00768781
View directory record Official record
Conditions
Insomnia
Interventions
Mindfulness-Based Stress Reduction, Mindfulness-Based Therapy for Insomnia, Wait-List + Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jul 21, 2026, 11:33 PM EDT