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ClinicalTrials.gov public records Last synced Sep 19, 2026, 4:53 AM EDT

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Showing 1–24 of 82 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hypertension, Portal Clear all
Completed No phase listed Observational

Endoscopic Ultrasound-Guided Portosystemic Pressure Gradient Measurements

NCT04668664
View directory record Official record
Conditions
Liver Cirrhosis, Liver Diseases, Hypertension, Portal
Interventions
EchoTip® Insight™ Portosystemic Pressure Gradient Measurement System (EchoTip® Insight™)
Device
Lead sponsor
Cook Research Incorporated
Industry
Eligibility
18 Years to 85 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
5
States / cities
Orange, California • Kansas City, Kansas • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 20, 2022 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 3 Interventional Results available

LiveSMART Trial to Prevent Falls in Patients With Cirrhosis

NCT05794555
View directory record Official record
Conditions
Cirrhosis, Liver, Portal Hypertension
Interventions
Enhanced Usual Care, Lactulose, Investigator recommended exercise, TeleTai-Chi (virtual)
Behavioral · Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
3
States / cities
Ann Arbor, Michigan • Philadelphia, Pennsylvania • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate

NCT02665117
View directory record Official record
Conditions
Hypertension
Interventions
Potassium Magnesium Citrate (KMgCit), Potassium Chloride (KCl), Chlorthalidone
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years and older
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
3
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 24, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

A Pilot Trial to Test the Feasibility of Utilizing Home Blood Pressure Monitoring to Optimize the Administration of Midodrine Among Decompensated Cirrhosis Patients

NCT05928624
View directory record Official record
Conditions
Cirrhosis, Liver, Portal Hypertension, Ascites Hepatic
Interventions
Withings Home Blood Pressure Device and Scale, Standard of Care
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational

Study of Capsule Endoscopy to Determine the Accuracy for Detection of Esophageal Varices

NCT01079416
View directory record Official record
Conditions
Esophageal Varices
Interventions
Capsule endoscopy, Esophagogastroduodenoscopy
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 85 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 31, 2013 · Synced Sep 19, 2026, 4:53 AM EDT
Withdrawn Phase 3 Interventional

Carvedilol vs Band Ligation vs Combination Therapy for Primary Prophylaxis of Variceal Bleeding

NCT02066649
View directory record Official record
Conditions
Portal Hypertension Related to Cirrhosis
Interventions
Carvedilol, Variceal band ligation
Drug · Procedure
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 4 Interventional Results available

Time Interval for Endoscopic Variceal Ligation

NCT01291277
View directory record Official record
Conditions
Variceal Bleeding
Interventions
Endoscopic Variceal Ligation
Device
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure

NCT03427164
View directory record Official record
Conditions
Portal Hypertension
Interventions
Transjugular Intrahepatic Portosystemic Shunt
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Sep 19, 2026, 4:53 AM EDT
Terminated Phase 2Phase 3 Interventional

NEPH-ROSIS (NEPHrology in CirRhOSIS) Pilot Trial: A Trial to Treat Acute Kidney Injury Among Hospitalized Cirrhosis Patients

NCT06000748
View directory record Official record
Conditions
Acute Kidney Injury, Cirrhosis, Portal Hypertension, Hepatorenal Syndrome, Acute Tubule Necrosis, Prerenal Failure
Interventions
MAP-Target Algorithm
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

3D Sonographic Measurement of Volumetric Flow in Transjugular Intrahepatic Porto-Systemic Shunts

NCT02046473
View directory record Official record
Conditions
Portal Hypertension, Liver Disease
Interventions
Volumetric Flow in TIPS
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 9, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Age-Related Changes in Body Composition

NCT01517113
View directory record Official record
Conditions
Hypertension, Atherosclerosis
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
50 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 3 Interventional

Decompression Intervention of Variceal Rebleeding Trial (DIVERT)

NCT00006161
View directory record Official record
Conditions
Esophageal and Gastric Varices, Liver Cirrhosis
Interventions
Transjugular Intrahepatic Portosystemic Shunt (TIPS), Distal Splenorenal Shunt
Procedure
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 2003
U.S. locations
5
States / cities
Miami, Florida • Atlanta, Georgia • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2010 · Synced Sep 19, 2026, 4:53 AM EDT
Terminated Phase 2 Interventional Results available

A Study to Test Whether Two Different Doses of Avenciguat Help People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

NCT05161481
View directory record Official record
Conditions
Hypertension, Portal
Interventions
Avenciguat (BI 685509), Placebo matching Avenciguat (BI 685509)
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
6
States / cities
Pasadena, California • Rialto, California • Miami Lakes, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Patient-Portal vs Text-based Hypertension Monitoring Among Black Medicaid/Medicare Patients

NCT05186831
View directory record Official record
Conditions
Hypertension, Cardiovascular Diseases
Interventions
Texting, Online patient portal
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2022 · Synced Sep 19, 2026, 4:53 AM EDT
Active, not recruiting Not applicable Interventional

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes

NCT01047735
View directory record Official record
Conditions
Type 2 Diabetes Mellitus, Obesity
Interventions
Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
Procedure · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
25 Years to 55 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2028
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Enrolling by invitation No phase listed Observational

International Registry of Congenital Portosystemic Shunt (IRCPSS)

NCT06041906
View directory record Official record
Conditions
Congenital Portosystemic Shunt, CPSS (Congenital Portosystemic Shunt)
Interventions
Shunt Closure
Procedure
Lead sponsor
Prof. Valérie Mc Lin
Other
Eligibility
1 Day and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
2
States / cities
New Haven, Connecticut • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Surrogate Markers of Portal Pressure

NCT02508298
View directory record Official record
Conditions
Portal Hypertension, Cirrhosis
Interventions
HVPG, Indocyanine Green Retention test, Liver stiffness measurement, Spleen stiffness measurement
Procedure · Drug · Device
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 85 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
2
States / cities
New Haven, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 24, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational

Non-invasive Evaluation of Portal Hypertension in Patients With Compensated Advanced Chronic Liver Disease by Assessment of Spleen Stiffness Using VCTE by FibroScan.

NCT03778411
View directory record Official record
Conditions
Advanced Chronic Liver Disease, NASH
Interventions
VCTE with splenic stiffness measurement
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
298 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 18, 2024 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Phase 2 Interventional

SHAPE of Portal Hypertension in Children

NCT04720456
View directory record Official record
Conditions
Hypertension, Portal
Interventions
SHAPE measurement using the ultrasound contrast agent Sonazoid (perfluorobutane microbubbles), SHAPE measurement using the ultrasound contrast agent Lumason (sulfur hexafluoride lipid-type A microspheres)
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
6 Years to 21 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Non-invasive Diagnosis of Portal Hypertension With Acoustic Radiation Force Impulse (ARFI)

NCT01644656
View directory record Official record
Conditions
Portal Hypertension, Chronic Liver Disease
Interventions
ARFI ultrasound
Device
Lead sponsor
VA Connecticut Healthcare System
Federal
Eligibility
18 Years to 85 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
New Haven, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 5, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Velacur by Sonic Incytes for Portal Hypertension

NCT04576897
View directory record Official record
Conditions
Portal Hypertension, Chronic Advanced Liver Disease
Interventions
Velacur
Diagnostic Test
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Sep 4, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Phase 1 PK Study to Evaluate the PK of CIN-107 in Subjects With Hepatic Impairment

NCT05961397
View directory record Official record
Conditions
Hypertension
Interventions
baxdrostat
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
5
States / cities
Rialto, California • Miami, Florida • Orlando, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension

NCT02230683
View directory record Official record
Conditions
Liver Cirrhosis, Hepatic Cirrhosis, Portal Hypertension
Interventions
IDN-6556
Drug
Lead sponsor
Conatus Pharmaceuticals Inc.
Industry
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
16
States / cities
West Haven, Connecticut • Washington D.C., District of Columbia • Miami, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Assessment of Portal Hypertension With Multiparametric MRI

NCT03436550
View directory record Official record
Conditions
Portal Hypertension, Clinically Significant Portal Hypertension
Interventions
mpMRI, ARFI US
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Sep 19, 2026, 4:53 AM EDT