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ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:41 PM EDT

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Showing 1–24 of 86 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Hypoxemia Clear all
Completed No phase listed Observational

Reverse Trendelenburg Positioning and Its Effect on Outcomes: a Retrospective Study of Consecutive Patients

NCT02984657
View directory record Official record
Conditions
Aspiration, Respiratory, Hypoxia, Perioperative Period, Supine Position
Interventions
Surgical patients in 2012 with anesthesia and nursing staff less attuned to intraoperative RTP., Surgical patients in 2015 with enhanced anesthesia and nursing staff awareness and use of intraoperative RTP.
Procedure
Lead sponsor
C. Michael Dunham
Other
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Youngstown, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 7, 2016 · Synced Oct 20, 2026, 8:41 PM EDT
Terminated Not applicable Interventional

Correlation of Peak Tidal Inspiratory Flow Measured Before and After Extubation in Adult Patients With Hypoxemia

NCT04971148
View directory record Official record
Conditions
Hypoxemic Respiratory Failure
Interventions
HFNC flow set at patient peak tidal inspiratory flow, HFNC flow set at 1.33 times of patient peak tidal inspiratory flow, HFNC flow set at 1.67 times of patient peak tidal inspiratory flow, HFNC flow set at 2 times of patient peak tidal inspiratory flow
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 14, 2023 · Synced Oct 20, 2026, 8:41 PM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude

NCT07517068
View directory record Official record
Conditions
Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
Interventions
ACETAZOLAMIDE oral capsule, Placebo Arm
Drug · Device
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Intermittent Hypoxia on Glycemic Control

NCT06490900
View directory record Official record
Conditions
Hypoxemia
Interventions
Intermittent hypoxia, Intermittent normoxia
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 25, 2025 · Synced Oct 20, 2026, 8:41 PM EDT
Terminated Not applicable Interventional

Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Hypoxemia

NCT04619719
View directory record Official record
Conditions
Covid19
Interventions
Hyperbaric Oxygen Therapy (HBOT)
Device
Lead sponsor
Legacy Health System
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Bozeman, Montana • Mineola, New York • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 9, 2023 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD

NCT04159116
View directory record Official record
Conditions
Laryngospasm, Hypoxemia
Interventions
Prophylactic suctioning when clinically indicated
Other
Lead sponsor
Envision Healthcare Scientific Intelligence, Inc.
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Moon Township, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 17, 2021 · Synced Oct 20, 2026, 8:41 PM EDT
Completed No phase listed Observational

Point of Care Ultrasound Evaluation in the Post-Anesthesia Unit

NCT04410757
View directory record Official record
Conditions
Hypotension, Hypoxemia, Altered Mental Status, Urine Output Low, Chest Pain
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Oct 20, 2026, 8:41 PM EDT
Completed No phase listed Observational Results available

Prevention of Opioid-Induced Hypoxemia

NCT04453722
View directory record Official record
Conditions
Non-cardiac Surgery
Interventions
Oxalert Monitor Mode, Oxalert Normal mode
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 20, 2026, 8:41 PM EDT
Recruiting No phase listed Observational

Lung Function Monitoring During Hypoxemia Episodes

NCT06535074
View directory record Official record
Conditions
Hypoxemia of Newborn
Interventions
Detecting changes in lung volume with hypoxemia episodes
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Treating Sleep Apnea Induced Hypoxemia With Oxygen in Acute Stroke Patients

NCT03300063
View directory record Official record
Conditions
Stroke, Acute
Interventions
Low flow nocturnal oxygen
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 25, 2021 · Synced Oct 20, 2026, 8:41 PM EDT
Active, not recruiting Phase 3 Interventional

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

NCT04534959
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 120 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
8
States / cities
Birmingham, Alabama • Denver, Colorado • Cincinnati, Ohio + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Pulse Oximetry With Automated Verbal Prompts

NCT02930863
View directory record Official record
Conditions
Hypoxemia
Interventions
pulse oximetry software, Brief post-PACU stay survey.
Other · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 15, 2019 · Synced Oct 20, 2026, 8:41 PM EDT
Not yet recruiting Phase 4 Interventional

Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial

NCT07199192
View directory record Official record
Conditions
Hypoxemia, Severe Acute Respiratory Syndrome
Interventions
Corticosteroid
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects

NCT01477450
View directory record Official record
Conditions
Hypoxemia, Hypobaric Hypoxemia
Interventions
Pulse-dose oxygen, Cylinder oxygen delivery
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 26, 2014 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Results available

Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

NCT06374225
View directory record Official record
Conditions
Critical Illness, Wounds and Injury, Disease Attributes, Pathologic Processes
Interventions
Automated Titration (O2matic)
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional

Evaluation of POC Pulse-dose Demand Oxygen Delivery for Nocturnal Hypoxemia

NCT06000332
View directory record Official record
Conditions
Nocturnal Hypoxemia
Interventions
InogenOne Rove 6 Portable Oxygen Concentrator
Device
Lead sponsor
Inogen Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Statesville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2024 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Flow Settings During High Flow Nasal Cannula for Adult Hypoxemia Patients

NCT03738345
View directory record Official record
Conditions
Hypoxemia
Interventions
HFNC flow
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 20, 2026, 8:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Capnography Prevent Hypoxemia During Endoscopic Retrograde Cholangiopancreatography and Endoscopic Ultrasound?

NCT00675415
View directory record Official record
Conditions
Hypoxemia
Interventions
Capnography
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
263 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Oct 20, 2026, 8:41 PM EDT
Not listed No phase listed Observational

Perioperative Vaping Complications

NCT05912023
View directory record Official record
Conditions
Vaping, Complication of Anesthesia
Interventions
Not listed
Lead sponsor
Navy Medical Center San Diego
Federal
Eligibility
12 Years to 80 Years
Enrollment
300 participants
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 17, 2024 · Synced Oct 20, 2026, 8:41 PM EDT
Completed No phase listed Observational

Race-Specific Propofol Titration to Effect for Procedural Sedation

NCT03290859
View directory record Official record
Conditions
Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
Interventions
Titrate propofol monotherapy infusion to effect
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
2,780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2019 · Synced Oct 20, 2026, 8:41 PM EDT
Active, not recruiting Not applicable Interventional

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

NCT06501118
View directory record Official record
Conditions
Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia, Hypoxia, Hypoxic Respiratory Failure
Interventions
Education, Epic notification alert
Other · Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
3,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

NCT06327373
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
Oxygen, Room air
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
11
States / cities
Durham, North Carolina • Henderson, North Carolina • Roxboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 20, 2026, 8:41 PM EDT
Recruiting Not applicable Interventional

The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants

NCT05298748
View directory record Official record
Conditions
Apnea of Prematurity, Intermittent Hypoxemia, Bradycardia
Interventions
Womb sound recordings
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
1 Week to 5 Weeks
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 5, 2025 · Synced Oct 20, 2026, 8:41 PM EDT
Terminated Phase 2 Interventional Results available

Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest

NCT02989168
View directory record Official record
Conditions
Idiopathic Pulmonary Fibrosis, Hypoxemia
Interventions
GBT440
Drug
Lead sponsor
Global Blood Therapeutics
Industry
Eligibility
45 Years to 85 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
6
States / cities
Birmingham, Alabama • Denver, Colorado • New Orleans, Louisiana + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2020 · Synced Oct 20, 2026, 8:41 PM EDT