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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Hypoxemia Clear all
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude

NCT07517068
View directory record Official record
Conditions
Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
Interventions
ACETAZOLAMIDE oral capsule, Placebo Arm
Drug · Device
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

The Effect of Womb Recordings on Maturation of Respiratory Control in Preterm Infants

NCT05298748
View directory record Official record
Conditions
Apnea of Prematurity, Intermittent Hypoxemia, Bradycardia
Interventions
Womb sound recordings
Other
Lead sponsor
Case Western Reserve University
Other
Eligibility
1 Week to 5 Weeks
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 4, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated Phase 1Phase 2 Interventional

Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation

NCT00041548
View directory record Official record
Conditions
Lung Disease, Hypoxemia, Respiratory Acidosis
Interventions
nitric oxide for inhalation, Oxygen
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
Up to 120 Hours
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 18, 2016 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting No phase listed Observational

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

NCT05336890
View directory record Official record
Conditions
Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
Interventions
Not listed
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
30 Weeks to 83 Months
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

The Effect of Cetirizine HCl on Exercise-induced Arterial Hypoxemia in Highly-trained Swimmers

NCT05095311
View directory record Official record
Conditions
Exercise-induced Arterial Hypoxemia
Interventions
Cetirizine HCl, Placebo
Drug · Other
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Bloomington, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 4, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

"Facemask Use During High-intensity Interval Exercise in Temperate and Hot Environments"

NCT05143801
View directory record Official record
Conditions
Hypoxemia, Physiological Stress
Interventions
High-intensity interval exercise with surgical face mask in a temperate environment, High-intensity interval exercise with surgical face mask in a hot environment, High-intensity interval exercise without using a surgical face mask in a hot environment, High-intensity interval exercise without using a surgical face mask in a temperate environment
Device · Other
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Apr 24, 2022 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

NCT05256069
View directory record Official record
Conditions
Vasodilation, Hypoxia
Interventions
Propranolol Pill, Placebo
Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 45 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Not listed Phase 1Phase 2 Interventional

Tolerability and Efficacy of RJX in Patients With COVID-19

NCT04708340
View directory record Official record
Conditions
COVID-19, Acute Respiratory Distress Syndrome, SARS-CoV-2, Hypoxemia
Interventions
Rejuveinix (RJX) Active Comparator, Placebo Comparator
Drug
Lead sponsor
Reven Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
237 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
3
States / cities
Houston, Texas • New Braunfels, Texas
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Point of Care Ultrasound Evaluation in the Post-Anesthesia Unit

NCT04410757
View directory record Official record
Conditions
Hypotension, Hypoxemia, Altered Mental Status, Urine Output Low, Chest Pain
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Aug 30, 2020 · Synced Jul 21, 2026, 4:53 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude

NCT05971290
View directory record Official record
Conditions
Hypoxemia, Altitude Hypoxia
Interventions
Continuous positive airway pressure, Ambient air
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Jul 21, 2026, 4:53 AM EDT
Not listed No phase listed Observational

Perioperative Vaping Complications

NCT05912023
View directory record Official record
Conditions
Vaping, Complication of Anesthesia
Interventions
Not listed
Lead sponsor
Navy Medical Center San Diego
Federal
Eligibility
12 Years to 80 Years
Enrollment
300 participants
Timeline
2023 – 2025
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Terminated Phase 1 Interventional

Pilot Study of Pentoxifylline for Hepatopulmonary Syndrome

NCT00593658
View directory record Official record
Conditions
Hepatopulmonary Syndrome
Interventions
pentoxifylline
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 8, 2015 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Phase 3 Interventional

Follow-up at School-age of Children Who Participated in the Efficacy Study of Nitric Oxide for Premature Infants

NCT00152542
View directory record Official record
Conditions
Prematurity, Respiratory Distress Syndrome,Hypoxemia
Interventions
Inhaled nitric oxide, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
4 Years to 6 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 11, 2013 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Volume Guarantee Ventilation in Preterm Infants With Frequent Episodes of Hypoxemia

NCT01727505
View directory record Official record
Conditions
Episodic Hypoxemia in Mechanically Ventilated Preterm Infants
Interventions
Sequence A: Conventional-Volume Guarantee, Sequence B: Volume Guarantee-Conventional
Device
Lead sponsor
University of Miami
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Race-Specific Propofol Titration to Effect for Procedural Sedation

NCT03290859
View directory record Official record
Conditions
Unconsciousness, Apnea, Postanesthetic, Sedative Overdose, Hypoxemia
Interventions
Titrate propofol monotherapy infusion to effect
Procedure
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 80 Years
Enrollment
2,780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Jul 21, 2026, 4:53 AM EDT
Recruiting Phase 2 Interventional

Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia

NCT07037836
View directory record Official record
Conditions
COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia
Interventions
Inhaled Treprostinil (Tyvaso Nebulizer)
Drug
Lead sponsor
Bastiaan Driehuys
Other
Eligibility
40 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Pulse Oximetry With Automated Verbal Prompts

NCT02930863
View directory record Official record
Conditions
Hypoxemia
Interventions
pulse oximetry software, Brief post-PACU stay survey.
Other · Behavioral
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 14, 2019 · Synced Jul 21, 2026, 4:53 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

NCT06327373
View directory record Official record
Conditions
Pulmonary Hypertension
Interventions
Oxygen, Room air
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
11
States / cities
Durham, North Carolina • Henderson, North Carolina • Roxboro, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Hypoxemia in Infants After Palliative Surgery

NCT00327977
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 3 Years
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2011
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 1, 2014 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest

NCT04170062
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial, Pulmonary Fibrosis, Hypoxemia, Dyspnea, Oxygen Inhalation Therapy
Interventions
Nasal Delivery of High-Flow Air and Oxygen Therapy, Nasal Delivery of Oxygen Therapy
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
30 Years to 100 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 23, 2024 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Treating Sleep Apnea Induced Hypoxemia With Oxygen in Acute Stroke Patients

NCT03300063
View directory record Official record
Conditions
Stroke, Acute
Interventions
Low flow nocturnal oxygen
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Jul 21, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Intermittent Hypoxia on Glycemic Control

NCT06490900
View directory record Official record
Conditions
Hypoxemia
Interventions
Intermittent hypoxia, Intermittent normoxia
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 24, 2025 · Synced Jul 21, 2026, 4:53 AM EDT
Completed No phase listed Observational

Intermittent Hypoxemia and Acute Kidney Injury Study (IHAKI Study)

NCT02837276
View directory record Official record
Conditions
Intermittent Hypoxemia, Acute Kidney Injury, Preterm Infant
Interventions
Not listed
Lead sponsor
Elie G. Abu Jawdeh, MD
Other
Eligibility
Up to 2 Months
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Jul 21, 2026, 4:53 AM EDT
Not listed Not applicable Interventional

Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation

NCT02961933
View directory record Official record
Conditions
Intubation
Interventions
Apneic oxygenation, Pre-oxgenation with NRB, NIPPV, BVM
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Jul 21, 2026, 4:53 AM EDT