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ClinicalTrials.gov public records Last synced Oct 25, 2026, 3:01 AM EDT

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Showing 1–24 of 93 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Infertility, Male Clear all
Active, not recruiting No phase listed Observational

Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration

NCT03291522
View directory record Official record
Conditions
Azoospermia, Nonobstructive, Infertility, Male
Interventions
Ultrasound-guided rete testis flushing and aspiration
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Oct 25, 2026, 3:01 AM EDT
Not listed Not applicable Interventional

Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation

NCT04142112
View directory record Official record
Conditions
Infertility, Infertility, Male
Interventions
Ohana IVF Sperm Preparation Kit (OHB035), Standard IVF Preparation Kit (OHB037)
Device
Lead sponsor
Ohana BioSciences
Industry
Eligibility
25 Years to 37 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
7
States / cities
Tempe, Arizona • Clearwater, Florida • Rockville, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 9, 2020 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting Not applicable Interventional

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

NCT04452305
View directory record Official record
Conditions
Infertility, Male, Cancer, Autoimmune Disorder
Interventions
Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
Procedure
Lead sponsor
University of Pittsburgh
Other
Eligibility
Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Completed No phase listed Observational

Hormonal Regulation of Puberty and Fertility

NCT01511588
View directory record Official record
Conditions
Endocrine Disease, Infertility, Hypogonadism, Amenorrhea, Adolescents
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
14 Years to 100 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
2
States / cities
Bethesda, Maryland • Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants

NCT07097259
View directory record Official record
Conditions
Hypogonadism
Interventions
Test: Follitropin alfa, Reference: Follitropin alfa, Zoladex
Combination Product · Drug
Lead sponsor
EMD Serono Research & Development Institute, Inc.
Industry
Eligibility
18 Years to 45 Years · Male only
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Completed No phase listed Observational

Small RNA Pathways in Mammalian Gametogenesis

NCT02864329
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 90 Years · Male only
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 19, 2024 · Synced Oct 25, 2026, 3:01 AM EDT
Active, not recruiting Not applicable Interventional

To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.

NCT07369362
View directory record Official record
Conditions
Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate, Euploidy Rate
Interventions
microfludics semen processing device
Device
Lead sponsor
MotilityCount aps
Industry
Eligibility
21 Years to 45 Years
Enrollment
1,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Completed Phase 2 Interventional

Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer

NCT00080808
View directory record Official record
Conditions
Prostate Cancer
Interventions
Alprostadil (E1), Papaverine, Phentolamine mesylate, Sildenafil citrate, conventional surgery
Drug · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Up to 65 Years · Male only
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2012 · Synced Oct 25, 2026, 3:01 AM EDT
Completed No phase listed Observational Results available

Impact of Sperm DNA Integrity on In Vitro Cycles

NCT01232465
View directory record Official record
Conditions
Male Infertility, Unexplained Infertility, Abortion, Habitual
Interventions
Not listed
Lead sponsor
Northwell Health
Other
Eligibility
Male only
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 11, 2014 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting No phase listed Observational

Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)

NCT07357701
View directory record Official record
Conditions
Primary Ovarian Insufficiency, Azoospermia, Oligospermia
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 100 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
2
States / cities
Bethesda, Maryland • Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Terminated Phase 3 Interventional Results available

Aromatase Inhibitors in the Treatment of Male Infertility

NCT00440180
View directory record Official record
Conditions
Obesity, Oligospermia
Interventions
Anastrozole, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
16 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 6, 2016 · Synced Oct 25, 2026, 3:01 AM EDT
Completed No phase listed Observational

A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery

NCT00596739
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2016 · Synced Oct 25, 2026, 3:01 AM EDT
Active, not recruiting Not applicable Interventional

A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard Abstinence

NCT07062237
View directory record Official record
Conditions
Infertility, Male Factor Infertility
Interventions
Ultrashort abstinence, Standard abstinence
Other
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 42 Years
Enrollment
187 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility

NCT07740161
View directory record Official record
Conditions
Male Infertility, Low Sperm Quality, Low Testosterone, Low Energy, Low Libido
Interventions
WeNatal For Him Supplement
Dietary Supplement
Lead sponsor
WeNatal
Industry
Eligibility
30 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Terminated Phase 3 Interventional Results available

Microsurgical Varicocelectomy Versus No Surgery in Men With a Palpable Varicocele and an Abnormal Semen Analysis

NCT00767338
View directory record Official record
Conditions
Pregnancy, Infertility
Interventions
Timed intercourse, Microsurgical varicocelectomy, Intrauterine insemination
Behavioral · Procedure
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Aurora, Colorado • New Haven, Connecticut • Ann Arbor, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2013 · Synced Oct 25, 2026, 3:01 AM EDT
Withdrawn Phase 2Phase 3 Interventional

Androxal in Male Infertility

NCT02160704
View directory record Official record
Conditions
Infertility
Interventions
Enclomiphene citrate, Placebo
Drug · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 35 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 11, 2019 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prospective Study on Power Prenatal Vitamins for Males on YO Score At-home Sperm Test Results

NCT05951075
View directory record Official record
Conditions
Spermatogenesis and Semen Disorders, Infertility, Male
Interventions
Power Prenatal for Sperm
Dietary Supplement
Lead sponsor
The Bird and Be Co Inc
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
174 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Encino, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Oct 25, 2026, 3:01 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Evaluating the Safety and Clinical Efficacy of the BAIBYS™ System in Intracytoplasmic Sperm Injection (ICSI)

NCT06990906
View directory record Official record
Conditions
Male Infertility, Azoospermia
Interventions
BAIBYS Sperm selection, Intra cytoplasmatic sperm injection, Conventional manual sperm selection
Device · Procedure
Lead sponsor
BAIBYS Fertility
Industry
Eligibility
21 Years to 42 Years
Enrollment
260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Stamford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0

NCT02839447
View directory record Official record
Conditions
Male Infertility
Interventions
Diagnostic
Diagnostic Test
Lead sponsor
Aytu BioPharma, Inc.
Industry
Eligibility
21 Years to 45 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
6
States / cities
Miami, Florida • New Orleans, Louisiana • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2024 · Synced Oct 25, 2026, 3:01 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Duloxetine on Male Fertility

NCT03038867
View directory record Official record
Conditions
Infertility, Male, Depression
Interventions
Duloxetine, Placebo
Drug
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 12, 2020 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Testicular Evaluation of Azoospermia Using Micro-Ultrasound

NCT06941922
View directory record Official record
Conditions
Azoospermia
Interventions
Not listed
Lead sponsor
Paul Shin
Other
Eligibility
18 Years and older · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 11, 2025 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting Not applicable Interventional

Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples

NCT04298255
View directory record Official record
Conditions
Infertility, Male
Interventions
Round Spermatid Injection (ROSI), Half ROSI-half Sperm Donor Fertilization
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Male only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 17, 2026 · Synced Oct 25, 2026, 3:01 AM EDT
Recruiting Not applicable Interventional

Testicular Tissue Cryopreservation in Children

NCT02872532
View directory record Official record
Conditions
Cancer, Cancer-Related Condition, Infertility
Interventions
Testicular tissue cryopreservation
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
0 Years to 17 Years · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2030
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 25, 2026, 3:01 AM EDT
Completed Not applicable Interventional Results available

Home Semen Testing in Men Beginning Attempts to Conceive

NCT05503862
View directory record Official record
Conditions
Male Infertility
Interventions
YoSperm
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Male only
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2026 · Synced Oct 25, 2026, 3:01 AM EDT