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Showing 1–24 of 67 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Internal Fixation Clear all
Withdrawn No phase listed Observational

Treatment Of Supracondylar Fractures Closed Reduction And Circular Ring External Fixation Versus Open Reduction and Internal Fixation

NCT02196311
View directory record Official record
Conditions
Supracondylar Humerus Fractures
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional

A Clinical Trial for the Surgical Treatment of Elderly Distal Radius Fractures

NCT01589692
View directory record Official record
Conditions
Distal Radius Fracture
Interventions
Open Reduction and Internal Fixation, External Fixation, Percutaneous Pinning, Closed Reduction and casting
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
20
States / cities
Farmington, Connecticut • Louisville, Kentucky • Baltimore, Maryland + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Sep 6, 2026, 7:22 PM EDT
Not listed Not applicable Interventional

Sinus Tarsi Versus Extensile Lateral Approach for Calcaneus Fractures

NCT02446470
View directory record Official record
Conditions
Intra-articular Fractures
Interventions
Sinus Tarsi approach, Extensile Lateral approach
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Sep 6, 2026, 7:22 PM EDT
Recruiting Not applicable Interventional

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

NCT06863129
View directory record Official record
Conditions
Metastatic Bone Disease
Interventions
Internal Fixation, Resection and reconstruction
Procedure
Lead sponsor
Michelle Ghert, MD
Other
Eligibility
18 Years and older
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
7
States / cities
Aurora, Colorado • Fort Wayne, Indiana • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 6, 2026, 7:22 PM EDT
Terminated Not applicable Interventional

Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

NCT02597972
View directory record Official record
Conditions
Closed Fracture Proximal Humerus, Four Part
Interventions
Fracture repair, Fracture repair with joint replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 6, 2026, 7:22 PM EDT
Completed No phase listed Observational

Pediatric Femur Fracture Registry

NCT03211546
View directory record Official record
Conditions
Femoral Shaft Fracture
Interventions
Conservative (non-surgical) treatment, Surgical treatment
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
Up to 16 Years
Enrollment
322 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 6, 2026, 7:22 PM EDT
Recruiting Not applicable Interventional

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

NCT07244211
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Hip arthroplasty, Internal fixation
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
20
States / cities
Irvine, California • Los Angeles, California • Miami, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures

NCT00429585
View directory record Official record
Conditions
Tibial Fractures
Interventions
reamed, interlocking intramedullary nail, locking periarticular plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2020
U.S. locations
27
States / cities
Birmingham, Alabama • Davis, California • San Francisco, California + 22 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Sep 6, 2026, 7:22 PM EDT
Terminated Not applicable Interventional Results available

Comparison of Subcutaneous INFIX and EXFIX for Anterior Pelvic Ring Fractures Requiring Stabilization

NCT02403154
View directory record Official record
Conditions
Anterior Pelvic Ring Fractures
Interventions
Internal Fixator, External fixator
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 120 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Sep 6, 2026, 7:22 PM EDT
Completed No phase listed Observational

Development and Validation of Intraoperative Image-quality Criteria

NCT01660490
View directory record Official record
Conditions
Proximal Femur Fractures
Interventions
ORIF
Procedure
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
Not listed
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2014 · Synced Sep 6, 2026, 7:22 PM EDT
Completed No phase listed Observational Results available

MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants

NCT03132246
View directory record Official record
Conditions
Open Reduction and Internal Fixation of Extremity Fractures
Interventions
Blood draws
Diagnostic Test
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2020 · Synced Sep 6, 2026, 7:22 PM EDT
Terminated Not applicable Interventional Results available

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

NCT01430182
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2016 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional

Open Reduction Internal Fixation of Calcaneus Fractures With and Without Bone Graft

NCT00582686
View directory record Official record
Conditions
Calcaneus Fractures
Interventions
ORIF of Calcaneus with bone grafting, ORIF of Calcaneus without bone grafting
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2013 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional Results available

Platelet Rich Plasma Injection in Pilon Fractures

NCT02481869
View directory record Official record
Conditions
Fracture
Interventions
Arthrocentesis/PRP, Arthrocentesis/Saline
Biological · Drug
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 4, 2021 · Synced Sep 6, 2026, 7:22 PM EDT
Recruiting Phase 4 Interventional

Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients

NCT07561541
View directory record Official record
Conditions
Fracture Lower Leg, Diabetes, Fracture Fixation, Internal
Interventions
Cefadroxil 500 mg Capsules, Clindamycin, Bactrim DS
Drug
Lead sponsor
Texas Tech University Health Sciences Center, El Paso
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Los Angeles, California • El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Early Elbow Motion Improve Patient Outcomes After Surgically Treated Elbow Fractures?

NCT05980312
View directory record Official record
Conditions
Elbow Fracture, Range of Motion, Immobilization
Interventions
Splint Immobilization, Early Motion
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 6, 2026, 7:22 PM EDT
Terminated Phase 4 Interventional Results available

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

NCT01693367
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
21 Years to 120 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Sacramento, California • Columbia, Missouri • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 6, 2026, 7:22 PM EDT
Not yet recruiting Not applicable Interventional

Study on Outcomes of Proximal Humerus Fractures

NCT07060664
View directory record Official record
Conditions
Proximal Humerus Fracture
Interventions
open reduction internal fixation, intramedullary nail, reverse total shoulder arthroplasty
Procedure
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
65 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Not applicable Interventional Results available

Sacroiliac (SI) Screws: The Effect of SI Screw Removal on Patient-Reported Pain and Functional Outcomes

NCT02652611
View directory record Official record
Conditions
Sacroiliac Joint, Pain, Pelvis
Interventions
SI Screw Removal Surgery, Non-screw removal treatment (non-operative management)
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Sep 6, 2026, 7:22 PM EDT
Completed No phase listed Observational

MatrixRIB Implants for Surgical Stabilization of Flail Chest Injuries: A Registry

NCT00810251
View directory record Official record
Conditions
Flail Chest
Interventions
MatrixRIB (FDA Approval # K081623)
Device
Lead sponsor
Legacy Biomechanics Laboratory
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 5, 2011 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Dose-Escalation Study of HTX-034 Following Bunionectomy

NCT04398329
View directory record Official record
Conditions
Bunions, Postoperative Pain
Interventions
HTX-034 low dose, HTX-034 high dose, Luer lock applicator, Bupivacaine HCl
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
4
States / cities
Phoenix, Arizona • Bellaire, Texas • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Sep 6, 2026, 7:22 PM EDT
Completed Phase 3 Interventional

Assessment of Fixation Strategies for Severe Open Tibia Fractures

NCT01494519
View directory record Official record
Conditions
Severe Open Fractures of the Tibia (Shin) Bone
Interventions
Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
Procedure
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 27 more
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Sep 6, 2026, 7:22 PM EDT