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Showing 1–24 of 71 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Intestinal Permeability Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Performance of 13C Mannitol for in Vivo Measurement of Small Intestinal Permeability

NCT02603822
View directory record Official record
Conditions
Impaired Small Intestinal Permeability
Interventions
12C mannitol, Indomethacin, 13C mannitol, Lactulose
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 3, 2019 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Phase 4 Interventional Results available

rHGH and Intestinal Permeability in Intestinal Failure

NCT01380366
View directory record Official record
Conditions
Short Bowel Syndrome
Interventions
Somatropin, Seven Day Food Diary, Blood Tests (standard of care), Fasting, Sugar Permeability Test, Urine Collection
Drug · Procedure · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoids, Exercise, Gut-Derived Phenolics

NCT03249571
View directory record Official record
Conditions
Exercise and Gut-derived Phenolics
Interventions
Flavonoid supplement, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Sep 5, 2026, 2:35 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Tributyrin: Time Course & Efficacy to Improve Health & Performance

NCT06501898
View directory record Official record
Conditions
Metabolite Concentration, Gut Permeability, Inflammation, Sleep, Performance
Interventions
CoreBiome, Placebo
Dietary Supplement
Lead sponsor
Florida State University
Other
Eligibility
30 Years to 50 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Sep 5, 2026, 2:35 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Microbiome in Colorectal Cancer Onset and Progression

NCT05368688
View directory record Official record
Conditions
Colorectal Cancer, Tumor, CRC, GI Cancer, Gastrointestinal Cancer
Interventions
Not listed
Lead sponsor
Viome
Industry
Eligibility
50 Years to 80 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Dec 26, 2022 · Synced Sep 5, 2026, 2:35 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sucrose Breath Test to Determine Intestinal Permeability in IBS

NCT01674088
View directory record Official record
Conditions
Irritable Bowel Syndrome
Interventions
Not listed
Lead sponsor
Metabolic Solutions Inc.
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 9, 2014 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Early Phase 1 Interventional

Effects of a Western-type Diet on Colorectal Inflammation

NCT00866450
View directory record Official record
Conditions
Colorectal Inflammation
Interventions
Western style diet (high fat and low in calcium), Prudent-style diet (low fat and high in calcium)
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
50 Years to 72 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2012 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Phase 1 Interventional

Intestinal Permeability in Response to Treatment in Eosinophilic Esophagitis Patients

NCT01641913
View directory record Official record
Conditions
Eosinophilic Esophagitis
Interventions
Absorbable sugars
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 23, 2014 · Synced Sep 5, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Mango Intake and Gut and Cardiometabolic Health in Hispanic/Latino Adolescents

NCT07125001
View directory record Official record
Conditions
Cardiometabolic Health Indicators, Vascular Function in Healthy Volunteers, Inflammation
Interventions
Ataulfo mango
Other
Lead sponsor
University of California, Davis
Other
Eligibility
12 Years to 19 Years
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Phase 1 Interventional Results available

Intestinal Permeability in Preterm Infants

NCT01756040
View directory record Official record
Conditions
Prematurity, Intestinal Permeability
Interventions
Lactulose -rhamnose solution
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
Up to 4 Days
Enrollment
211 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Betaine, Exercise Performance, and Gut Permeability

NCT06392360
View directory record Official record
Conditions
Metabolic Disturbance, Permeability; Increased
Interventions
Betaine, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 65 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

NCT06419231
View directory record Official record
Conditions
Gut Health
Interventions
Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo
Dietary Supplement
Lead sponsor
Supplement Formulators, Inc.
Industry
Eligibility
21 Years to 70 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Change in Permeability of the Small Intestine After Treatment With Gluten

NCT02098057
View directory record Official record
Conditions
Gastrointestinal Disorders
Interventions
Gluten Healthy, Placebo
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 7, 2019 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional

Cocoa and Metabolic Health in Prediabetes

NCT02203240
View directory record Official record
Conditions
Prediabetes
Interventions
Cocoa, Placebo
Other
Lead sponsor
Virginia Polytechnic Institute and State University
Other
Eligibility
40 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Blacksburg, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Phase 3 Interventional

Effect of VSL#3 on Intestinal Permeability in Pediatric Crohn's Disease

NCT00944736
View directory record Official record
Conditions
Crohn's Disease
Interventions
VSL#3, Placebo
Dietary Supplement
Lead sponsor
Children's Mercy Hospital Kansas City
Other
Eligibility
11 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 9, 2014 · Synced Sep 5, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Prebiotic Effects of California Grapes on Gut Health and Cardiometabolic Health in Overweight Men and Women

NCT06544954
View directory record Official record
Conditions
Arterial Stiffness, Blood Pressure, Dysbiosis, Inflammation, Permeability; Increased
Interventions
Freeze-dried grape powder, Placebo powder
Dietary Supplement · Other
Lead sponsor
University of California, Davis
Other
Eligibility
45 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Davis, California
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Vitamin D and Adipose Tissue Inflammation

NCT01477034
View directory record Official record
Conditions
Vitamin D Deficiency, Obesity, Type 2 Diabetes Mellitus, Intestinal Permeability
Interventions
Vitamin D3
Dietary Supplement
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 3, 2014 · Synced Sep 5, 2026, 2:35 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

NCT07650058
View directory record Official record
Conditions
Healthy Participants
Interventions
High-Glycemic Breakfast Containing Cereal and Fresh Mango, High-Glycemic Breakfast Containing Cereal and Table Sugar
Other
Lead sponsor
Ball State University
Other
Eligibility
18 Years to 45 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of a Cranberry Beverage on Intestinal Permeability and Gastrointestinal Function in Generally Healthy Adults

NCT03957239
View directory record Official record
Conditions
Intestinal Permeability, Gastrointestinal Function
Interventions
Cranberry Beverage, Control Beverage
Other
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 50 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 6, 2020 · Synced Sep 5, 2026, 2:35 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Intestinal Permeability and Endometriosis

NCT03042923
View directory record Official record
Conditions
Endometriosis
Interventions
lactulose:mannitol (L:M) oral challenge
Drug
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 27, 2020 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude

NCT04111263
View directory record Official record
Conditions
Gastrointestinal Injury, Acute Mountain Sickness
Interventions
FP, Placebo, High altitude, Sea level
Dietary Supplement · Other
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Study of Perturbation of Human Small Intestinal Colonic Permeability

NCT06033222
View directory record Official record
Conditions
Healthy
Interventions
Ricinoleic Acid 750 mg, Ricinoleic Acid 1500 mg, Ricinoleic Acid 3000 mg, Placebo
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Vitamin D Repletion in Chronic Kidney Disease

NCT00772772
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Vitamin D3
Drug
Lead sponsor
Rockefeller University
Other
Eligibility
50 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Sep 5, 2026, 2:35 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults

NCT03611400
View directory record Official record
Conditions
Intestinal Barrier Function
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of Florida
Other
Eligibility
21 Years to 50 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 20, 2019 · Synced Sep 5, 2026, 2:35 AM EDT