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Conditions: Cardiovascular, Comorbidity, Diabetes, Inflammatory Joint Diseases, Chronic Kidney Diease, Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease
Interventions: Not listed
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 50 Years to 99 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Effect of Drug
Interventions: Placebo, Calcium Fructoborate; Dietary Supplement
Lead sponsor: Auburn University; Other
Eligibility: 40 Years to 65 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Auburn, Alabama

Conditions: Smoking, Smoking Cessation
Interventions: Comprehensive Relapse Prevention Intervention, Standard Treatment Counseling, Nicotine Replacement Therapy (NRT); Behavioral · Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 100 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Joint Pain
Interventions: Joint Health Product, Placebo, Glucosamine / Chondroitin; Dietary Supplement
Lead sponsor: U.S. Nutraceuticals, LLC; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Sausalito, California

Conditions: Rheumatoid Arthritis
Interventions: Mobile Health App; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Ann Arbor, Michigan • Rochester, Minnesota

Conditions: Spinal Cord Injury, Shoulder Pain
Interventions: Shoulder home exercise program; Other
Lead sponsor: Rancho Research Institute, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 148 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Downey, California

Conditions: Freeman-Burian Syndrome, Freeman-Sheldon Syndrome, Whistling Face Syndrome, Sheldon-Hall Syndrome, Freeman-Sheldon Syndrome Variant, Arthrogryposis Distal Type 1, Arthrogryposis Distal Type 3, Gordon Syndrome
Interventions: Guided Health History for Freeman-Burian Syndrome Questionnaire, Freeman-Burian syndrome Semi-Structured Quality of Life Interview, Medical Records Review, PTSD Checklist for DSM-5, Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale, Review of Systems, FACE-Q | Craniofacial - Appearance of the Face, FACE-Q | Craniofacial - Appearance Distress, FACE-Q | Craniofacial - Facial Function; Other
Lead sponsor: Dufresne, Craig, MD, PC; Other
Eligibility: Not listed
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Rheumatoid Arthritis
Interventions: AD 452; Drug
Lead sponsor: Sosei; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 232 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2005
U.S. locations: 10
States / cities: Clearwater, Florida • Fort Lauderdale, Florida • Ocala, Florida + 7 more

Conditions: Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain, Knee Acute and Chronic Pain
Interventions: NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin; Dietary Supplement
Lead sponsor: Hofseth Biocare ASA; Industry
Eligibility: 20 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Chronic Mental Illness, Chronic Physical Illness
Interventions: Patient-Directed Wellness Account, Health Navigator; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 21 Years to 55 Years
Enrollment: 1,663 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
Interventions: POPOP (preoperative patient optimization program), SOC (standard of care); Other
Lead sponsor: University of Arkansas; Other
Eligibility: 18 Years to 80 Years
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Little Rock, Arkansas

Conditions: Hypertension, Arthritis, Coronary Artery Disease, Hepatitis, Diabetes, Asthma, Hyperlipidemia, HIV
Interventions: HARP Intervention; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Rheumatic Diseases, Arthritis
Interventions: Not listed
Lead sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); NIH
Eligibility: 18 Years to 100 Years
Enrollment: 7,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2001
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy, Bursitis, Depression, Anxiety, Diabetes Mellitus, Esophageal Reflux, HIV Infections, Hyperlipidemia, Hypertension, Insomnia, Irritable Bowel Syndrome, Obesity, Osteoporosis (Senile), Shoulder Pain, Sinusitis, Symptomatic Menopause, Urinary Incontinence, Urinary Tract Infection, Vaginitis
Interventions: Health Information Prescription; Other
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 224 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Bone Mineral Density, Hemophilia A, Hemophilia B
Interventions: DXA scan + MRI; Other
Lead sponsor: Baxalta now part of Shire; Industry
Eligibility: 25 Years and older · Male only
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Chronic Musculoskeletal Pain
Interventions: Practitioner-delivered CIH therapies, Combination of practitioner-delivered and self-care CIH therapies, Self-care CIH therapies; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 3,603 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 2
States / cities: Sepulveda, California • Seattle, Washington

Conditions: Osteoarthritis
Interventions: Diclofenac Sodium gel, 1%, Voltaren® Gel, Placebo; Drug
Lead sponsor: Glenmark Pharmaceuticals Ltd. India; Industry
Eligibility: 35 Years and older
Enrollment: 1,164 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 44
States / cities: Mesa, Arizona • Anaheim, California • Canoga Park, California + 32 more

Conditions: Knee Injuries, Joint Surface Knee Lesions
Interventions: Marketed Product - MP01, Other Surgical Treatments; Device · Procedure
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 1,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2034
U.S. locations: 3
States / cities: Washington D.C., District of Columbia • Indianapolis, Indiana • Oklahoma City, Oklahoma

Conditions: Gut -Microbiota, Inflammation Biomarkers, Pain Assessment, Joint Pain
Interventions: Wild blueberry, Placebo; Dietary Supplement
Lead sponsor: University of Nevada, Las Vegas; Other
Eligibility: 40 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Rheumatoid Arthritis
Interventions: Peer Support Program; Behavioral
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Pain, Atrophic, Goals, Impairment, Infiltration, Injury, Muscle Weakness, Pain, Pathology, Shoulder Pain, Syndrome, Tendinopathy
Interventions: Subacromial injection, Physical Therapy; Procedure · Other
Lead sponsor: University of Oregon; Other
Eligibility: 21 Years to 45 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Shoulder Pain, Chronic Pain, Musculoskeletal Injury
Interventions: Dry Needling, Sham Dry Needling; Device · Other
Lead sponsor: Army-Baylor University Doctoral Program in Physical Therapy; Other
Eligibility: 18 Years to 50 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Arthritis, Osteoarthritis, Rheumatoid Arthritis
Interventions: People with Arthritis Can Exercise; Behavioral
Lead sponsor: Centers for Disease Control and Prevention; Federal
Eligibility: 18 Years and older
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Gout
Interventions: Not listed
Lead sponsor: jasvinder singh; Federal
Eligibility: 18 Years to 110 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Minneapolis, Minnesota

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Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities

Joint Health Study

Preventing Smoking Relapse After Total Joint Replacement Surgery

Study to Evaluate the Safety and Efficacy of a Proprietary "Joint Health" Dietary Supplement in Subjects With Joint and Connective Tissue Pain

A Multi-Center Clinical Trial to Determine the Impact of a Mobile Health Application on Rheumatoid Arthritis Shared Decision Making

Maintenance of Shoulder Health and Function After Spinal Cord Injury

Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome

A Multicentre Trial to Determine the Efficacy of AD 452 in RA Subjects.

NT-II™ Collagen for Joint Discomfort and Function

Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project

Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA

The Health Access and Recovery Peer Program

Studies of the Natural History of Rheumatic Diseases

Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow

Osteoporosis and MRI Study in Hemophilia

Assessing Pain, Patient Reported Outcomes and Complementary and Integrative Health

To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).

Knee Cartilage Repair Registry

Dietary Wild Blueberries and Joint Health

Patient Rheumatoid Arthritis Social Support Study

Neurophysiology of Weakness and Exercise in Rotator Cuff Tendinopathy

Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling

Program Evaluation of People With Arthritis Can Exercise

CLinical Prediction Rule Score in Veterans