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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Limb Ischemia Clear all
Completed Phase 2 Interventional Results available

A Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial Occlusion

NCT01222117
View directory record Official record
Conditions
Acute Peripheral Arterial Occlusion
Interventions
Plasmin, Plasminogen Activator, Placebo
Biological · Other
Lead sponsor
Grifols Therapeutics LLC
Industry
Eligibility
18 Years and older
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Buffalo, New York • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 15, 2017 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Not applicable Interventional

Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment

NCT05411315
View directory record Official record
Conditions
Mechanical Ventilation Complication, Arterial Thrombosis, Limb Ischemia, Shock, Hypotension, Bloodstream Infection, Vasopressor Adverse Reaction, Renal Failure
Interventions
Restricted-use of arterial catheter, Standard-use of arterial catheter
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Feb 25, 2024 · Synced Sep 28, 2026, 2:19 AM EDT
Not listed Phase 1 Interventional

Safety Study of Using Stem Cells to Stimulate Development of New Blood Vessels in Peripheral Vascular Disease

NCT00113243
View directory record Official record
Conditions
Peripheral Vascular Diseases
Interventions
adult stem cells
Drug
Lead sponsor
Murphy, Michael P., MD
Individual
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 28, 2026, 2:19 AM EDT
Recruiting Not applicable Interventional

The ROAMM-EHR Study

NCT06263322
View directory record Official record
Conditions
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Interventions
Actionable remotely generated health data, Non-Actionable remotely generated health data
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
60 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 26, 2025 · Synced Sep 28, 2026, 2:19 AM EDT
Active, not recruiting No phase listed Observational

VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home

NCT05691023
View directory record Official record
Conditions
Ischemic Stroke, Upper Extremity Problem
Interventions
Vivistim System
Device
Lead sponsor
MicroTransponder Inc.
Industry
Eligibility
19 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 28, 2026, 2:19 AM EDT
Recruiting Not applicable Interventional

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

NCT05313165
View directory record Official record
Conditions
Critical Limb Ischemia, Chronic Limb-Threatening Ischemia, Peripheral Arterial Disease
Interventions
LimFlow Stent Graft System
Device
Lead sponsor
LimFlow, Inc.
Industry
Eligibility
18 Years to 95 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
30
States / cities
La Jolla, California • Palo Alto, California • San Francisco, California + 22 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Terminated Phase 3 Interventional

Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease

NCT00059644
View directory record Official record
Conditions
Peripheral Vascular Disease
Interventions
Ecraprost in lipid emulsion
Drug
Lead sponsor
Tanabe Pharma Corporation
Industry
Eligibility
40 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
20
States / cities
Phoenix, Arizona • Tucson, Arizona • Glendale, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 28, 2026, 2:19 AM EDT
Terminated Not applicable Interventional Results available

Dissolved Oxygen Dressing to Improve Chronic Wound Healing After Revascularization for Critical Limb Ischemia

NCT02046226
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Oxygenesys(TM) Dissolved Oxygen Dressing
Device
Lead sponsor
Halyard Health
Industry
Eligibility
21 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 11, 2015 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Phase 2 Interventional

Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia

NCT00721006
View directory record Official record
Conditions
Critical Limb Ischemia, Severe Leg Ischemia, Peripheral Artery Disease, Peripheral Vascular Disease
Interventions
MESENDO, Placebo
Biological
Lead sponsor
TCA Cellular Therapy
Industry
Eligibility
19 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Covington, Louisiana
Source: ClinicalTrials.gov public record
Updated May 8, 2014 · Synced Sep 28, 2026, 2:19 AM EDT
Active, not recruiting Phase 3 Interventional

Trial to Assess Chelation Therapy in Critical Limb Ischemia

NCT03982693
View directory record Official record
Conditions
Critical Limb Ischemia, Diabetes
Interventions
Edetate Disodium, Placebo
Drug · Other
Lead sponsor
Mt. Sinai Medical Center, Miami
Other
Eligibility
50 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Miami Beach, Florida
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Enrolling by invitation Not applicable Interventional

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke

NCT04534556
View directory record Official record
Conditions
Stroke, Chronic Stroke, Upper Extremity Paresis, Ischemic Stroke, Hemorrhagic Stroke
Interventions
Active Vagus Nerve Stimulation, Placebo Vagus Nerve Stimulation
Device
Lead sponsor
Baylor Research Institute
Other
Eligibility
22 Years to 79 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Not applicable Interventional

Laser Atherectomy Versus Angioplasty for the Treatment of Critical Limb Ischemia

NCT01579123
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Angioplasty, Laser atherectomy
Procedure
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Dallas, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Sep 28, 2026, 2:19 AM EDT
Terminated Phase 2 Interventional Results available

HEROIC (Heparin Requirement in Counterpulsation)

NCT00445211
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Heparin, Without Heparin
Drug · Other
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Sep 28, 2026, 2:19 AM EDT
Recruiting Not applicable Interventional

Cortical Recording and Stimulating Array Brain-Machine Interface

NCT01894802
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury, Above Elbow Amputation
Interventions
Implantation of CRS Arrays
Device
Lead sponsor
Michael Boninger
Other
Eligibility
22 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Retrospective Analysis of Patients With Full Thickness Wounds in Limbs With Critical Ischemia

NCT00760357
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Not listed
Lead sponsor
Southwest Regional Wound Care Center
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Nov 25, 2015 · Synced Sep 28, 2026, 2:19 AM EDT
No Longer Available No phase listed Expanded access

Expanded Access Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization

NCT03886506
View directory record Official record
Conditions
Critical Limb Ischemia (CLI)
Interventions
PLX-PAD
Biological
Lead sponsor
Pluristem Ltd.
Industry
Eligibility
45 Years to 99 Years
U.S. locations
2
States / cities
Clifton, New Jersey • Teaneck, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Phase 2 Interventional Results available

ACP-01 in Patients With Critical Limb Ischemia

NCT02551679
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
ACP-01, Placebo
Biological
Lead sponsor
Hemostemix
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
16
States / cities
Sacramento, California • Aurora, Colorado • Gainesville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Sep 28, 2026, 2:19 AM EDT
Recruiting No phase listed Observational

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

NCT05145478
View directory record Official record
Conditions
Femoral Arterial Calcification, Peripheral Arterial Disease, Claudication, Critical Limb Ischemia
Interventions
Shockwave Intravascular Lithotripsy (IVL)
Device
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
New Haven, Connecticut • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Not listed Phase 2 Interventional

UT-15C SR in the Treatment of Critical Limb Ischemia

NCT00445159
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
Drug
Lead sponsor
Southern Arizona Vascular Institute
Other
Eligibility
45 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
2
States / cities
Tucson, Arizona • Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2007 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Not applicable Interventional

Comparison of Lower vs Upper Extremity Injection Agitated Saline to Identify Patent Foramen Ovale With Echocardiography

NCT07009678
View directory record Official record
Conditions
Patent Foramen Ovale, Cryptogenic Stroke, Embolic Infarction
Interventions
intravenous access in greater saphenous vein compared to upper extremity site.
Diagnostic Test
Lead sponsor
St. John's Hospital
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Maple Grove, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 5, 2025 · Synced Sep 28, 2026, 2:19 AM EDT
Withdrawn Not applicable Interventional

Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI)

NCT07175129
View directory record Official record
Conditions
Chronic Limb Threatening Ischemia
Interventions
Transverse Tibial Bone Transport, TrueLok Elevate
Procedure · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries

NCT07387653
View directory record Official record
Conditions
Neuropathy;Peripheral, Limb Ischemia
Interventions
Lower-Extremity Perfusion Monitoring
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 28, 2026, 2:19 AM EDT
Active, not recruiting Not applicable Interventional Results available

LIFE-BTK Randomized Controlled Trial

NCT04227899
View directory record Official record
Conditions
Critical Limb Ischemia (CLI)
Interventions
Esprit BTK Device, Percutaneous Transluminal Angioplasty (PTA) Device
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
261 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
43
States / cities
Gilbert, Arizona • Little Rock, Arkansas • Deer Park, California + 36 more
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Sep 28, 2026, 2:19 AM EDT
Completed Not applicable Interventional

Ischemic Conditioning to Enhance Function (I-C-FUN) in Children With Cerebral Palsy

NCT04598711
View directory record Official record
Conditions
Cerebral Palsy
Interventions
RLIC, Sham Conditioning, Muscle Power training, Balance training, Treadmill Training
Behavioral
Lead sponsor
East Carolina University
Other
Eligibility
6 Years to 16 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2023 · Synced Sep 28, 2026, 2:19 AM EDT