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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Limb Ischemia Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

NCT03481205
View directory record Official record
Conditions
Acute Stroke
Interventions
Ischemic conditioning device
Device
Lead sponsor
Enrique Leira
Other
Eligibility
18 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Feasibility Study of the TGI Adipose-derived Stromal Cell (ASC)-Coated ePTFE Vascular Graft

NCT01305863
View directory record Official record
Conditions
Lower Limb Ischemia
Interventions
ASC coated ePTFE vascular graft, Propaten graft
Device
Lead sponsor
Tissue Genesis
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2022
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced Jul 23, 2026, 1:27 AM EDT
Completed No phase listed Observational

Peripheral Registry of Endovascular Clinical Outcomes "The PRIME Registry"

NCT02786173
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Critical Limb Ischemia
Interventions
Not listed
Lead sponsor
Metro Health, Michigan
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2021
U.S. locations
6
States / cities
Orlando, Florida • Springfield, Illinois • Wyoming, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2023 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Phase 2 Interventional Results available

Study of Hepatocyte Growth Factor (HGF) Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia Patients With Peripheral Ischemic Ulcers

NCT00189540
View directory record Official record
Conditions
Arterial Occlusive Disease, Peripheral Vascular Disease, Ischemia, Ulcers
Interventions
HGF plasmid, Placebo
Genetic
Lead sponsor
AnGes USA, Inc.
Industry
Eligibility
40 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
4
States / cities
Pensacola, Florida • Indianapolis, Indiana • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Phase 1 Interventional

VEGF Gene Transfer for Critical Limb Ischemia

NCT00304837
View directory record Official record
Conditions
Critical Limb Ischemia, Ischemia, Leg Ulcer
Interventions
pVGI.1 (VEGF-2)
Genetic
Lead sponsor
Losordo, Douglas, M.D.
Individual
Eligibility
21 Years and older
Timeline
Ends 2008
U.S. locations
3
States / cities
Birmingham, Alabama • Boston, Massachusetts • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 18, 2010 · Synced Jul 23, 2026, 1:27 AM EDT
Not listed No phase listed Observational

The Use of FlowMet-R Technology to Predict Wound Healing in CLI Patients in a Wound Care Center Setting

NCT05455554
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Flowmet-D, ABI
Diagnostic Test
Lead sponsor
Stanford University
Other
Eligibility
30 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jul 12, 2022 · Synced Jul 23, 2026, 1:27 AM EDT
Not listed Phase 2 Interventional

UT-15C SR in the Treatment of Critical Limb Ischemia

NCT00445159
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
Drug
Lead sponsor
Southern Arizona Vascular Institute
Other
Eligibility
45 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
2
States / cities
Tucson, Arizona • Springfield, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2007 · Synced Jul 23, 2026, 1:27 AM EDT
Not yet recruiting Not applicable Interventional

Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers

NCT07290673
View directory record Official record
Conditions
Diabetic Foot Ulcer (DFU)
Interventions
FoundationDRS Solo, Standard of Care
Other
Lead sponsor
Samaritan Biologics
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Hollywood, Florida
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Not applicable Interventional

A Non-significant Risk Clinical Study to Assess Perfusion Changes With Application of a TUS for Patients With PAD

NCT05100745
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
Therapeutic Device
Device
Lead sponsor
Vibrato Medical, Inc.
Industry
Eligibility
22 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Not applicable Interventional Results available

A Prospective Single-Arm Multicenter StuDy of the BarE TEmporary SPur StEnt System foR the tREatment of Vascular Lesions Located in the infrapoplitEal Arteries beLow the Knee (DEEPER REVEAL)

NCT05358353
View directory record Official record
Conditions
Peripheral Arterial Disease, Critical Limb Ischemia
Interventions
Bare Temporary Spur Stent System
Device
Lead sponsor
ReFlow Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
48
States / cities
Jonesboro, Arkansas • Little Rock, Arkansas • Orange, California + 44 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting Phase 3 Interventional

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

NCT04774159
View directory record Official record
Conditions
Peripheral Arterial Disease, Atherosclerosis of Extremities, Inflammation
Interventions
Colchicine 0.5 MG Oral Tablet, Colchicine-Placebo
Drug
Lead sponsor
Population Health Research Institute
Other
Eligibility
18 Years and older
Enrollment
6,150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
19
States / cities
New Haven, Connecticut • Gainesville, Florida • Tampa, Florida + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting Not applicable Interventional

Serrantor OCT Study

NCT06434194
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Serranator PTA Serration Catheter, PTA (Standard of Care)
Device · Drug
Lead sponsor
Cagent Vascular LLC
Industry
Eligibility
19 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Phase 2 Interventional

Study to Assess Efficacy and Safety of Bone Marrow Derived Stem Cells in Patients With Critical Limb Ischemia

NCT01867190
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
ASCT01 (Autologous Stem Cell Transplantation)
Biological
Lead sponsor
Lifecells, LLC.
Industry
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
North Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 21, 2019 · Synced Jul 23, 2026, 1:27 AM EDT
Not listed Phase 2 Interventional

Lower-Limb Adventitial Infusion of DexaMethasone Via Bullfrog to Reduce Occurrence of Restenosis After Atherectomy (ATX)-Based Revascularization

NCT02479620
View directory record Official record
Conditions
Chronic Limb Ischemia
Interventions
Dexamethasone Sodium Phosphate Injection, USP, 4 mg/mL
Drug
Lead sponsor
Mercator MedSystems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
10
States / cities
Little Rock, Arkansas • Denver, Colorado • Saginaw, Michigan + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Jul 23, 2026, 1:27 AM EDT
Completed No phase listed Observational

BEST vCLI Registry

NCT04191746
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
Not listed
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
1,009 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting No phase listed Observational

Pounce™ Thrombectomy System Retrospective Registry

NCT05868161
View directory record Official record
Conditions
Peripheral Arterial Disease, Acute Limb Ischemia
Interventions
Pounce Thrombectomy System
Device
Lead sponsor
SurModics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
9
States / cities
Peoria, Illinois • Munster, Indiana • Baton Rouge, Louisiana + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Active, not recruiting Not applicable Interventional

Esprit BTK Post-Approval Study

NCT06656364
View directory record Official record
Conditions
Chronic Limb-Threatening Ischemia
Interventions
Esprit BTK System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
36
States / cities
Scottsdale, Arizona • Tucson, Arizona • Fresno, California + 27 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Withdrawn Not applicable Interventional

Transverse Tibial Transport for Chronic Limb-Threatening Ischemia (CLTI)

NCT07175129
View directory record Official record
Conditions
Chronic Limb Threatening Ischemia
Interventions
Transverse Tibial Bone Transport, TrueLok Elevate
Procedure · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 95 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Phase 1Phase 2 Interventional

ALD-301 for Critical Limb Ischemia, Randomized Trial

NCT00392509
View directory record Official record
Conditions
Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
Interventions
ALDH-br bone marrow cells vs. mononuclear bone marrow cells
Procedure
Lead sponsor
Aldagen
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
5
States / cities
Birmingham, Alabama • Atlanta, Georgia • Indianapolis, Indiana + 2 more
Source: ClinicalTrials.gov public record
Updated May 13, 2009 · Synced Jul 23, 2026, 1:27 AM EDT
Completed No phase listed Observational

SCOPE CLI (Shifting Care and Outcomes for Patients With Endangered Limbs - Critical Limb Ischemia)

NCT03171259
View directory record Official record
Conditions
Critical Limb Ischemia
Interventions
care as usual
Other
Lead sponsor
Saint Luke's Health System
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
New Haven, Connecticut • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting Not applicable Interventional

Implementation of IVS3 for Upper Limb Motor Recovery

NCT06483230
View directory record Official record
Conditions
Neglect, Hemispatial, Stroke, Cardiovascular, Mirror Movement, Motor Activity
Interventions
Intensive Visual Stimulation Device
Device
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries

NCT07387653
View directory record Official record
Conditions
Neuropathy;Peripheral, Limb Ischemia
Interventions
Lower-Extremity Perfusion Monitoring
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jul 23, 2026, 1:27 AM EDT
Recruiting Phase 3 Interventional

Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

NCT04433572
View directory record Official record
Conditions
Peripheral Artery Disease, Critical Limb Ischemia
Interventions
Temsirolimus, Saline placebo
Drug
Lead sponsor
Mercator MedSystems, Inc.
Industry
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2032
U.S. locations
2
States / cities
Houma, Louisiana • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 4, 2025 · Synced Jul 23, 2026, 1:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)

NCT05888740
View directory record Official record
Conditions
Peripheral Arterial Disease
Interventions
VibratoSleeve Therapeutic Ultrasound Device
Device
Lead sponsor
Vibrato Medical, Inc.
Industry
Eligibility
65 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jul 23, 2026, 1:27 AM EDT