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Showing 1–24 of 29 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Extremity Muscle Strength Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Short Term Immobilization of the Lower Limb

NCT05072652
View directory record Official record
Conditions
Weakness, Muscle, Muscle Weakness, Muscle Loss, Muscle Atrophy, Injury, Knee
Interventions
Neuromuscular Electrical Stimulation, Action Observation + Mental Imagery
Other
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 40 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 18, 2022 · Synced Sep 13, 2026, 7:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training in Patients With Lower Extremity Fractures

NCT06496035
View directory record Official record
Conditions
Tibial Fractures, Lower Extremity Fracture
Interventions
Blood Flow Restriction with low load exercise, Therapeutic Exercise
Device · Other
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Sep 13, 2026, 7:40 AM EDT
Not yet recruiting Not applicable Interventional

The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, Biomechanics, and Pain Intensity

NCT06891001
View directory record Official record
Conditions
Gluteus Medius Muscle Strength, Lateral Hip Pain, Greater Trochanter Pain Syndrome, Gluteus Medius Tendinopathy, Gluteus Minimus Tendinopathy
Interventions
Unilateral neutral shoe insert, Bilateral Shoe Insert, Physical Therapy
Device · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Glendale, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 21, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Leg Heat Therapy in Elderly Individuals

NCT05543980
View directory record Official record
Conditions
Aging, Muscle Weakness
Interventions
Sham device, Leg heat therapy device
Device
Lead sponsor
Purdue University
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 13, 2026, 7:40 AM EDT
Recruiting Not applicable Interventional

Leg Heat Therapy in Peripheral Artery Disease

NCT05465070
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Leg heat therapy, Sham Control
Device
Lead sponsor
Indiana University
Other
Eligibility
50 Years and older
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Withdrawn Not applicable Interventional

Bilateral Versus Unilateral Strength Training After ACLR

NCT06032247
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Atrophy, Muscular, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
Interventions
Resistance exercise program- UL, Resistance exercise program- BL
Behavioral
Lead sponsor
University of Kansas
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Sep 13, 2026, 7:40 AM EDT
Recruiting Not applicable Interventional

Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery

NCT05381818
View directory record Official record
Conditions
Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
Interventions
Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury

NCT01555567
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Electrical Stimulation, Eccentric Exercise
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Sep 13, 2026, 7:40 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

HIFEM and Radiofrequency for Muscular System Function Improvement

NCT06703749
View directory record Official record
Conditions
Muscle Damage, Muscle Strength, Muscle Weakness
Interventions
Treatment with BTL-899M, Treatment with BTL-899M with intensities below therapeutic threshold
Device
Lead sponsor
BTL Industries Ltd.
Industry
Eligibility
22 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
3
States / cities
Scottsdale, Arizona • Greenwood Village, Colorado • Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated Nov 24, 2024 · Synced Sep 13, 2026, 7:40 AM EDT
Enrolling by invitation Not applicable Interventional

Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients

NCT07171346
View directory record Official record
Conditions
ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy, Muscle Atrophy or Weakness
Interventions
Zynex NexWave Electrotherapy Device
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
15 Years to 50 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Active, not recruiting Not applicable Interventional

Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury

NCT02274116
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
SHAM - Intermittent Room Air - room air mixture, AIH - Intermittent Hypoxia - hypoxia air mixture
Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size.

NCT03983070
View directory record Official record
Conditions
Healthy
Interventions
Seated Rowing Ergometer, Deadlift, Blood flow restriction
Other
Lead sponsor
Campbell University, Incorporated
Other
Eligibility
18 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Buies Creek, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 13, 2022 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Lower Extremity Muscle and Function in the Elderly: Study 2

NCT01614392
View directory record Official record
Conditions
Mobility Limitation
Interventions
High velocity low force Power Training, Low velocity high force Power Training
Behavioral
Lead sponsor
Tufts University
Other
Eligibility
70 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 9, 2018 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Electromyostimulation and Strength Walking for Knee Injuries

NCT02065518
View directory record Official record
Conditions
Knee Injury
Interventions
NMES, Strength Walking, Standard Rehabilitation Protocol
Device · Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 50 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Andrews Air Force Base, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Results available

Trial Evaluating Postop Pain and Muscle Strength Among Regional Anesthesia Techniques for Ambulatory ACL Reconstruction

NCT02584452
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Tear of Anterior Cruciate Ligament
Interventions
Mepivacaine, adductor canal continuous nerve catheter, Normal Saline as bolus followed by bupivacaine, adductor canal nerve block, ropivacaine and dexamethasone, Propofol, Fentanyl
Drug · Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
14 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Intensity Blood Flow Restriction Training Study

NCT03055260
View directory record Official record
Conditions
Muscle Mass
Interventions
Blood flow restriction cuff, Blood Flow restriction Cuff-Placebo
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 49 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Sep 13, 2026, 7:40 AM EDT
Not yet recruiting Not applicable Interventional

Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation

NCT07664995
View directory record Official record
Conditions
Lower Limb Amputation Above Knee, Below Knee Amputation
Interventions
Blood pressure cuff, Neuromuscular Electrical Stimulation
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

BFRT in Adolescents After ACL Reconstruction

NCT04390035
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
12 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 1, 2021 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees

NCT03389334
View directory record Official record
Conditions
Amputation
Interventions
massage
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Sep 24, 2018 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional

The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery

NCT03035266
View directory record Official record
Conditions
Knee Injuries
Interventions
Blood Flow Restriction, Standard rehabilitation
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 50 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
2
States / cities
West Point, New York • Fort Bragg, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2020 · Synced Sep 13, 2026, 7:40 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Acute Effects of Neurodynamics on Strength and Endurance in Athletes

NCT07721220
View directory record Official record
Conditions
Sciatic Leg Pain, Hamstring Muscle Tightness, Hamstring Muscle Strain, Hamstring Muscle Strength, Hamstring Injuries, Hamstring Injury Prevention, Hamstring Rupture, Sciatic Nerve Injury, Sciatic Radiculopathy, Lumbar Disc Herniation With Radiculopathy, Lumbar Disc Herniation
Interventions
Sciatic Slider, Sciatic Tensioner, Mechanically loaded neurodynamic sciatic floss, Elastic Resistance Band
Other · Device
Lead sponsor
High Point University
Other
Eligibility
18 Years to 30 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 13, 2026, 7:40 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Fatigability of Lower Limb Muscle in Older Adults: Protective Effects of Strength Training Exercise in Old Men and Women

NCT03888040
View directory record Official record
Conditions
Aging
Interventions
Exercise
Other
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 100 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 10, 2025 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional

To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength

NCT01080703
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Exercise
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Sep 13, 2026, 7:40 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Resistance Training With Blood Flow Restriction

NCT05863039
View directory record Official record
Conditions
Healthy
Interventions
Blood flow restriction, Regular training type 1, Regular training type 2
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 50 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Norman, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Sep 13, 2026, 7:40 AM EDT