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ClinicalTrials.gov public records Last synced Oct 2, 2026, 7:59 AM EDT

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Showing 25–48 of 133 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lower Extremity Musculoskeletal Injury Clear all
Not listed Not applicable Interventional

Comparison of TKAs Using Force Plate Analysis

NCT04163445
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee Injuries, Knee Arthritis
Interventions
MicroPort Orthopedics EVOLUTION Medial Pivot TKA, Depuy Synthes ATTUNE PCR TKA
Device
Lead sponsor
Russell Nevins, M.D.
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 2, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization

NCT07069426
View directory record Official record
Conditions
Muscle Disuse, Muscle Disuse Atrophy
Interventions
20 grams protein, 40 grams protein
Dietary Supplement
Lead sponsor
United States Army Research Institute of Environmental Medicine
Federal
Eligibility
17 Years to 39 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Natick, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Enrolling by invitation Not applicable Interventional

G7 Freedom Constrained Vivacit-E Liners

NCT05587244
View directory record Official record
Conditions
Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip
Interventions
Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2038
U.S. locations
10
States / cities
Birmingham, Alabama • Los Angeles, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Terminated Not applicable Interventional Results available

Foot and Ankle Range of Motion (Stretching) Apparatus

NCT00527748
View directory record Official record
Conditions
Plantar Fasciitis, Flatfoot, Calcaneus Fractures
Interventions
Non-Measuring Ankle Exerciser
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 2, 2026, 7:59 AM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)

NCT04113785
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions
Klassic Knee System
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 2, 2026, 7:59 AM EDT
Recruiting Not applicable Interventional

Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

NCT05926596
View directory record Official record
Conditions
Spasticity, Movement Disorders, Spinal Cord Injury
Interventions
Wearable Robotic Exoskeleton
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Feb 23, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

NCT03076034
View directory record Official record
Conditions
Distal Radius Fracture, Osteoporosis, Hip Fractures
Interventions
Reference Point Indentation
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
50 Years to 100 Years
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Recruiting Phase 2 Interventional

Preventing Injured Knees From osteoArthritis: Severity Outcomes

NCT06096259
View directory record Official record
Conditions
Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
Interventions
Metformin, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
9
States / cities
Atlanta, Georgia • Iowa City, Iowa • Lexington, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

The Sequestration of Holistic Stress Management Techniques for Adults

NCT06098755
View directory record Official record
Conditions
Stress, Job, PTSD, Hypervigilance, Hyperthyroidism, Migraine, Migraine With Aura, Immunodeficiency, Sickle Cell Trait, Sickle Cell Disease, Anemia, Sickle Cell, Anemia, Fatigue, Anxiety, Depression, Flat Feet, Lordosis, TBI (Traumatic Brain Injury), Rheumatoid Arthritis, Arthritis, Masturbation, Priapism, Erectile Dysfunction, Flight Reaction, Hypertension, Sexual Arousal Disorder, Hemorrhoids, Fibroid
Interventions
Holistic Medicine (HM)
Behavioral
Lead sponsor
Goddess Zena I. Jones
Other
Eligibility
22 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Withdrawn Not applicable Interventional

Bilateral Versus Unilateral Strength Training After ACLR

NCT06032247
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Atrophy, Muscular, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
Interventions
Resistance exercise program- UL, Resistance exercise program- BL
Behavioral
Lead sponsor
University of Kansas
Other
Eligibility
18 Years to 35 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Overland Park, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Clinical Outcomes Following Patellar Dislocation in Young Athletes

NCT03040232
View directory record Official record
Conditions
Patella Dislocation Recurrent, Patellar Dislocation
Interventions
biomechanical assessment
Other
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
12 Years to 25 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Oct 2, 2026, 7:59 AM EDT
Enrolling by invitation Not applicable Interventional

Conjoint Analysis of Patient Preferences in Joint Interventions

NCT02664337
View directory record Official record
Conditions
Arthritis, Femoroacetabular Impingement, Osteochondritis Dissecans, Hip Fractures, Ankle Fractures, Tibial Fractures
Interventions
Decision tool, Standard treatment information
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
2,310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

Mitigation of Major Hip Injury Due to Fall With a Smart Belt

NCT05245097
View directory record Official record
Conditions
Hip Injuries, Fractures, Hip, Fall Injury, Fall Risk, Osteoporosis, Osteoporosis Risk
Interventions
Tango Belt, Standard of Care (SOC)
Device · Other
Lead sponsor
ActiveProtective Technologies, Inc
Industry
Eligibility
65 Years and older
Enrollment
471 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
10
States / cities
Sacramento, California • Bensalem, Pennsylvania • Gwynedd, Pennsylvania + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Psychologically Informed Education Intervention for Adolescents With Atraumatic Lower-Extremity Injuries

NCT05701618
View directory record Official record
Conditions
Leg Injury
Interventions
Psychologically Informed Education Video Series, Anatomy and biomedical education videos
Other
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
12 Years to 18 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Hallux Limitus Treated With Dynamic Splinting: A Randomized, Controlled Trial

NCT00717691
View directory record Official record
Conditions
Hallux Limitus
Interventions
Metatarsophalangeal Extension Dynasplint System, Standard of Care
Device · Other
Lead sponsor
Dynasplint Systems, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
2
States / cities
Jonesboro, Georgia • Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 30, 2012 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Medial Tibial Stress Syndrome Prevention

NCT07256808
View directory record Official record
Conditions
Medial Tibial Stress Syndrome
Interventions
Resistance Training
Other
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 65 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Glassboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effects of an Isometric Loading Intervention on Lower Extremity Landing Biomechanics in Individuals With Patellar Tendinopathy

NCT03262181
View directory record Official record
Conditions
Tendinopathy
Interventions
Isometric Exercise, Sham Transcutaneous Electrical Nerve Stimulation
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
15 Years to 28 Years · Male only
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Results available

An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

NCT03809520
View directory record Official record
Conditions
Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
Interventions
pedCAT
Radiation
Lead sponsor
J L Marsh
Other
Eligibility
18 Years to 70 Years
Enrollment
97 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Terminated Not applicable Interventional

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

NCT04537013
View directory record Official record
Conditions
Knee Injuries, Cartilage Injury, Cartilage Disease, Knee Discomfort
Interventions
Microfracture, Microfracture plus placement of Chondro-Gide® ACC
Procedure · Device
Lead sponsor
Geistlich Pharma AG
Industry
Eligibility
18 Years to 55 Years
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
3
States / cities
Phoenix, Arizona • Stamford, Connecticut • Johns Creek, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 13, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using SWE and MFI

NCT05608824
View directory record Official record
Conditions
Lower Extremity Musculoskeletal Injury
Interventions
Shear wave elastography and microvascular flow imaging.
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
Eugene, Oregon • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Nordic Hamstring Exercise After ACL Reconstruction Reconstruction

NCT05738200
View directory record Official record
Conditions
ACL Injury, Muscle Weakness, Neuromuscular Manifestations
Interventions
Nordic Hamstring Exercise
Other
Lead sponsor
University of Toledo
Other
Eligibility
18 Years to 35 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 21, 2023 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Walking Gait Biomechanics Following Knee Joint Effusion

NCT03805464
View directory record Official record
Conditions
Knee Injuries, Knee Osteoarthritis
Interventions
Knee Joint Effusion
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 35 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Oct 2, 2026, 7:59 AM EDT
Terminated Not applicable Interventional

Gait Retraining Enhances Athletes' Technique

NCT03918681
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Knee Osteoarthritis
Interventions
Therapeutic Intervention
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 2, 2026, 7:59 AM EDT
Completed Not applicable Interventional

Gait-Training Using Wearable Sensors

NCT04270565
View directory record Official record
Conditions
Shin Splint, Running-related Injury
Interventions
In-Field Gait-Training, Home Exercise
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 2, 2026, 7:59 AM EDT