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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:35 PM EST

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Showing 25–48 of 178 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lower Limb Amputation Clear all

Conditions: Lower Extremity Amputation
Interventions: Torsionally adaptive prosthesis with 0:1 coupling ratio, Torsionally adaptive prosthesis with 1:6 coupling ratio, Torsionally adaptive prosthesis with 1:4 coupling ratio, Torsionally adaptive prosthesis with 1:3 coupling ratio, Torsionally adaptive prosthesis with 1:2 coupling ratio; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Lower Limb Amputation
Interventions: Prosthetic Suction or Pin Socket, Prosthetic LimbLogic Vacuum Socket; Device
Lead sponsor: Ohio Willow Wood; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 2
States / cities: Columbus, Ohio • Mount Sterling, Ohio

Conditions: Limb Amputation, Extremity Amputation
Interventions: Limb transplantation; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2030
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Amputation, Prosthesis User
Interventions: Liner perforated with very small diameter holes, Liner perforated with somewhat larger diameter holes, Liner-liner, As-prescribed liner; Device
Lead sponsor: VA Puget Sound Health Care System; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 180 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Severe Distal Tibia Injury, Severe Ankle Injury, Severe Foot Injury, Major Soft Tissue Loss, Major Bone Articular Surface Loss, Major Ankle Articular Surface Loss
Interventions: Not listed
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 60 Years
Enrollment: 664 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2019
U.S. locations: 33
States / cities: Birmingham, Alabama • San Diego, California • San Francisco, California + 26 more

Conditions: Phantom Limb Pain After Amputation, Lower Limb Amputation, Upper Limb Amputation, Phantom Pain, Chronic Pain
Interventions: Operant Conditioning with Peripheral Stimulation, Control Group with Peripheral Stimulation Only; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Albany, New York

Conditions: Lower Limb Amputation Below Knee
Interventions: As-prescribed stiffness, Two categories stiffer than the as-prescribed stiffness, Two categories less stiff than the as-prescribed stiffness; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 70 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation
Interventions: Traditional fabricated prosthetic socket, Direct manufactured (DM) prosthetic socket; Device
Lead sponsor: Ohio Willow Wood; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Mount Sterling, Ohio

Conditions: Lower Extremity Surgical Amputation, Post-amputation Phantom Limb Pain
Interventions: Experimental continuous peripheral nerve blocks, Control continuous peripheral nerve blocks; Drug
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 8
States / cities: San Diego, California • Boston, Massachusetts • Cleveland, Ohio + 1 more

Conditions: Amputation
Interventions: Residual limb revision; Procedure
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 3
States / cities: Bethesda, Maryland • Boston, Massachusetts • Cambridge, Massachusetts

Conditions: Critical Limb Ischemia
Interventions: Open surgical revascularization, Endovascular revascularization; Procedure · Device
Lead sponsor: Carelon Research; Other
Eligibility: 18 Years and older
Enrollment: 1,843 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2022
U.S. locations: 144
States / cities: Birmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 102 more

Conditions: Amputation
Interventions: Not listed
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 89 Years
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Surgical Wound, Diabetes, Amputation Wound, Incision Wound, Peripheral Arterial Disease, Breast Cancer, Diabetic Foot
Interventions: Transcu O2®; Device
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 85 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Elevated Metabolic Cost
Interventions: Gait Training; Other
Lead sponsor: Brooke Army Medical Center; Federal
Eligibility: 18 Years to 45 Years
Enrollment: 66 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2007
U.S. locations: 1
States / cities: Fort Sam Houston, Texas

Conditions: Critical Limb Ischemia
Interventions: Liposuction, Stem Cell Injection; Procedure · Other
Lead sponsor: Ageless Regenerative Institute; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Amputation, Amputation; Postoperative, Sequelae, Wound Dehiscence, Seroma, Wound Infection, Surgical, Lymph Leakage
Interventions: PREVENA™ PEEL & PLACE™ Dressing Kit; Device
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 18 Years and older
Enrollment: 272 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Valhalla, New York • Philadelphia, Pennsylvania

Conditions: Amputation, Neuropathy
Interventions: Somatosensation Device, Baseline; Device · Other
Lead sponsor: Shirley Ryan AbilityLab; Other
Eligibility: 18 Years to 89 Years
Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Ambulation With the "Take Home" or Passive Prosthesis, Ambulation With the Motorized Prosthesis in the "Off" Configuration, Ambulation With the Motorized Prosthesis in the "Transparent" Condition, Ambulation With the Motorized Prosthesis in the "Powered" Condition
Interventions: Passive prosthesis, Motorized prosthesis; Device
Lead sponsor: Northern Arizona University; Other
Eligibility: 18 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Flagstaff, Arizona

Conditions: Amputation, Anesthesia, Local, Opioid Use
Interventions: Liposomal bupivacaine; Drug
Lead sponsor: Loma Linda University; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Amputation
Interventions: RECOVER Prosthetic Ankle-Feet System; Device
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 89 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Lower-Limb Amputation
Interventions: Exercise self-management, Attention control; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 89 Years
Enrollment: 95 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Traumatic Amputation of Lower Extremity
Interventions: Ischemic Preconditioning; Other
Lead sponsor: University of Illinois Chicago; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lower Limb Amputation
Interventions: KinetiGait; Device
Lead sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Diabetic Foot Ulcer
Interventions: Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 90 Years
Enrollment: 69 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Baltimore, Maryland

Search by objective public record fields.

Pivot-Flex Foot: Optimal Coupling Ratio Between Transverse and Sagittal-plane Motions Using a Torsionally Adaptive Prosthesis for Individuals With Lower Limb Amputation

Evaluation of Limb Health Associated With a Prosthetic Vacuum Socket System

Vascularized Composite Allotransplantation for Multiple Extremity Amputations

Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration

Outcomes Following Severe Distal Tibia, Ankle and/or Foot Trauma: Comparison of Limb Salvage Versus Transtibial Amputation Protocol

Operant Conditioning of Sensory Brain Responses to Reduce Phantom Limb Pain in People With Limb Amputation

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance

Clinical Evaluation of Direct Manufactured Prosthetic Sockets

Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

AMI Construction in Lower Extremity Residual Limbs

Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia

Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living

EO2 Oxygen Delivery To Study Success Rate of Surgically Closed Wounds

The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation

Autologous Adipose-Derived Stromal Cell Delivered Via Intramuscular Injections for the Treatment of Critical Limb Ischemia

Evaluation of Closed Incision Negative Pressure Dressing (PREVENA) to Prevent Lower Extremity Amputation Wound Complications

Somatosensation Device Trial

Investigation of Motorized Lower-limb Prostheses

Use of Long-acting Bupivacaine In Lower Extremity Amputation

Impact of Improving Footwear Options

Walking Exercise Sustainability Through Telehealth for Veterans With Lower-limb Amputation

Improving Mobility and Function Following Transfemoral Amputation: A Novel Approach to Reverse Volumetric Muscle Loss

KinetiGait- Analysis of Depth Camera to Assist Gait Analysis for Unilateral Transtibial/Transfemoral Amputees

Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration