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ClinicalTrials.gov public records Last synced Oct 2, 2026, 5:50 AM EDT

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Showing 25–48 of 133 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Lumbar Spinal Stenosis Clear all
Withdrawn Not applicable Interventional

Indirect vs. Direct Decompression for Treatment of Central Stenosis: RCT

NCT04708977
View directory record Official record
Conditions
Patients With Spinal Stenosis Indicated for LLIF
Interventions
One-level lateral lumbar interbody fusion with Indirect Decompression, One-level lateral lumbar interbody fusion with Direct Decompression
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2021 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Not applicable Interventional

Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine

NCT02023372
View directory record Official record
Conditions
Intervertebral Disc Disease, Intervertebral Disc Degeneration, Spondylosis, Spondylolisthesis, Spinal Stenosis
Interventions
NuCel with Autograft
Other
Lead sponsor
NuTech Medical, Inc
Industry
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 2, 2026, 5:50 AM EDT
Withdrawn Not applicable Interventional

Comparison of the Order of Treatment in Lumbar Spinal Stenosis

NCT02103543
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
physical therapy, lumbar interlaminar epidural steroid injection, epidural steroid injection
Other · Procedure · Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 23, 2017 · Synced Oct 2, 2026, 5:50 AM EDT
Completed No phase listed Observational

Perioperative Local Anesthesia Block in Spine Surgery

NCT05094427
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Disc Herniation, Lumbar Spinal Stenosis
Interventions
Preoperative fluoroscopically-guided dorsal ramus block placed by the operative neurosurgeon
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
232 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Oct 2, 2026, 5:50 AM EDT
Completed No phase listed Observational Results available

Postmarket Outcomes Study for Evaluation of the Superion™ Spacer

NCT04563793
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Superion™ IDS
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
21 Years and older
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
23
States / cities
Fountain Valley, California • Larkspur, California • San Diego, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Oct 2, 2026, 5:50 AM EDT
Withdrawn Not applicable Interventional

Proprio Spine Measurement Tool

NCT07023393
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Intervertebral Disc Displacement, Spinal Curvatures, Spinal Osteochondrosis, Spinal Osteophytosis, Spinal Stenosis, Spondylitis, Spondylosis
Interventions
Intraoperative spinal measurement system
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Phase 4 Interventional Results available

Efficacy of Pregabalin in Patients With Radicular Pain

NCT00908375
View directory record Official record
Conditions
Neuropathy; Radicular, Lumbar, Lumbosacral, Failed Back Surgery Syndrome, Spinal Stenosis, Herniated Disc
Interventions
Pregabalin, Sugar Pill
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 64 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 13, 2014 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Not applicable Interventional Results available

The STEPS - Totalis™ Trial

NCT02079038
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Totalis, Comparator Surgical Procedure
Device · Procedure
Lead sponsor
VertiFlex, Incorporated
Industry
Eligibility
55 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
19
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 16 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2020 · Synced Oct 2, 2026, 5:50 AM EDT
Active, not recruiting Not applicable Interventional

A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)

NCT04192591
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Superion™ IDS device
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
45 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2041
U.S. locations
23
States / cities
Carlsbad, California • Larkspur, California • Rancho Mirage, California + 20 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 2, 2026, 5:50 AM EDT
Withdrawn No phase listed Observational

Radiation Exposure Reduction Protocol for Minimally Invasive Lumbar Decompression (mild) Techniques

NCT06651138
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Radiation Exposure
Interventions
Fluoroscopy
Radiation
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Oct 2, 2026, 5:50 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.

NCT06157177
View directory record Official record
Conditions
Sciatica Acute, Lumbar Spinal Stenosis
Interventions
Metaxalone 640 mg Oral Tablet
Drug
Lead sponsor
Primus Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
24
States / cities
Auburn, Alabama • Valley Village, California • Aventura, Florida + 21 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 2, 2026, 5:50 AM EDT
Not yet recruiting Not applicable Interventional

VR-Cognitive Behavioral Therapy Prehabilitation for Spinal Deformity Surgery

NCT07777679
View directory record Official record
Conditions
Degenerative Spine Disease, Spinal Stenosis Lumbar
Interventions
Virtual Reality-Based CBT Prehabilitation (VR-CBT), CBT Prehabilitation without Virtual Reality
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years to 75 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Irvine, California • Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

NCT00405691
View directory record Official record
Conditions
Low Back Pain, Leg Pain, Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
"TOPS System" - Total Posterior Arthroplasty Implant
Device
Lead sponsor
Impliant, Ltd.
Industry
Eligibility
40 Years to 75 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2006
U.S. locations
16
States / cities
Beverly Hills, California • Daly City, California • New Haven, Connecticut + 12 more
Source: ClinicalTrials.gov public record
Updated May 18, 2011 · Synced Oct 2, 2026, 5:50 AM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion

NCT03327272
View directory record Official record
Conditions
Stenosis, Herniated Nucleus Pulposus, Degenerative Disc Disease, Spondylosis, Myelopathy, Radiculopathy, Myeloradiculopathy
Interventions
Methylprednisolone, Saline
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 2, 2026, 5:50 AM EDT
Completed No phase listed Observational

Examining the Effects of Dorsal Column Stimulation on Pain From Lumbar Spinal Stenosis Related to Epidural Lipomatosis.

NCT05811143
View directory record Official record
Conditions
Lipomatosis, Low Back Pain
Interventions
Spinal Cord Stimulator
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Oct 2, 2026, 5:50 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Assessing Superion Clinical Endpoints vs. Decompression

NCT03048955
View directory record Official record
Conditions
Spinal Stenosis, Lumbar Region With Neurogenic Claudication
Interventions
Superion® IDS, Direct decompression Surgery
Device · Procedure
Lead sponsor
VertiFlex, Incorporated
Industry
Eligibility
45 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Birmingham, Alabama • Carlsbad, California • Celebration, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2019 · Synced Oct 2, 2026, 5:50 AM EDT
Terminated Not applicable Interventional

Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix (DBM) Mixed With Autograft

NCT00254852
View directory record Official record
Conditions
Stenosis, Spondylolisthesis, Degenerative Disc Disease
Interventions
Posterior Lateral Fusion (PLF), Anterior Lumbar Interbody Fusion (ALIF), Transforaminal lumbar interbody fusion (TLIF), Posterior lumbar interbody fusion (PLIF), Extreme lateral interbody fusion (XLIF)
Procedure
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
6
States / cities
Long Beach, California • San Diego, California • New Hartford, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Nov 21, 2013 · Synced Oct 2, 2026, 5:50 AM EDT
Recruiting No phase listed Observational

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

NCT05648474
View directory record Official record
Conditions
Intervertebral Disc Degeneration, Stenosis, Spinal, Spondylolisthesis, Spinal Deformity, Spinal Instability
Interventions
Somatosensory evoked potential [SSEP] intraoperative monitoring
Diagnostic Test
Lead sponsor
Alphatec Spine, Inc.
Industry
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 2, 2026, 5:50 AM EDT
Not listed Phase 2 Interventional

Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine

NCT04066296
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Liposomal bupivacaine
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Oct 2, 2026, 5:50 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Multimodal Analgesia Versus Routine Care Pain Management

NCT01861743
View directory record Official record
Conditions
Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
Interventions
Multimodal Analgesia, Patient controlled analgesia
Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
Not listed
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 29, 2018 · Synced Oct 2, 2026, 5:50 AM EDT
Active, not recruiting Not applicable Interventional

LimiFlex Clinical Trial for the Treatment of Degenerative Spondylolisthesis With Spinal Stenosis

NCT03115983
View directory record Official record
Conditions
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Interventions
LimiFlex, Fusion Instrumentation, Decompression, Fusion
Device · Procedure
Lead sponsor
Empirical Spine, Inc.
Industry
Eligibility
25 Years to 80 Years
Enrollment
299 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2026
U.S. locations
28
States / cities
Tempe, Arizona • Oakland, California • Redwood City, California + 24 more
Source: ClinicalTrials.gov public record
Updated Aug 7, 2025 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Early Phase 1 Interventional

Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain

NCT00370799
View directory record Official record
Conditions
Low Back Pain
Interventions
Caudal epidural injection, Caudal Epidural Injection with generic Celestone, Caudal Epidural Injection with Celestone, Caudal Epidural Injection with DepoMedrol
Drug
Lead sponsor
Pain Management Center of Paducah
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 16, 2013 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Not applicable Interventional

Dry Needling and Spinal Manipulation vs. Conventional PT for Lumbar Spinal Stenosis

NCT03167736
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
electric dry needling, manipulation, conventional physical therapy
Other
Lead sponsor
Alabama Physical Therapy & Acupuncture
Other
Eligibility
50 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Canton, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 12, 2024 · Synced Oct 2, 2026, 5:50 AM EDT
Completed Not applicable Interventional

Physical Activity Intervention for Patients Following Lumbar Spine Surgery

NCT04591249
View directory record Official record
Conditions
Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
Interventions
Physical activity intervention, Usual care
Behavioral · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 2, 2026, 5:50 AM EDT