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ClinicalTrials.gov public records Last synced Nov 4, 2026, 2:56 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 95 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Lumbar Spine Surgery Clear all

Conditions: Low Back Pain, Chronic Pain, Surgery, Back Pain, Low, Back Pain Lower Back Chronic
Interventions: Standard Care (SC), Enriched Pain Management Pathway (EPM); Behavioral
Lead sponsor: Dan Rhon; Federal
Eligibility: 18 Years to 75 Years
Enrollment: 267 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 3
States / cities: Honolulu, Hawaii • San Antonio, Texas • Tacoma, Washington

Conditions: Lumbar Spine Surgery
Interventions: DepoDur; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 98 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Interventions: Tranexamic Acid, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Degenerative Disc Disease
Interventions: CALIBER; Device
Lead sponsor: Globus Medical Inc; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Miami Beach, Florida • Charlotte, North Carolina

Conditions: Evoked Potentials, Visual
Interventions: SightSaver Visual Stimulator; Device
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Lumbar Disc Disease
Interventions: NOCISCAN-LS Disc MR Spectroscopy; Other
Lead sponsor: Nocimed, LLC; Other
Eligibility: 18 Years to 70 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Plano, Texas

Conditions: Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
Interventions: Physical activity intervention, Usual care; Behavioral · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Spinal Degenerative Disorder
Interventions: Physical activity intervention, Usual care; Behavioral · Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline; Drug
Lead sponsor: John O'Toole; Other
Eligibility: 18 Years to 80 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Lumbar Spinal Stenosis
Interventions: MILD® (Minimally Invasive Lumbar Decompression), Epidural Steroid Injection; Device · Drug
Lead sponsor: Coastal Orthopedics & Sports Medicine; Other
Eligibility: 18 Years and older
Enrollment: 38 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Bradenton, Florida

Conditions: Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons, Chronic Low Back Pain, Scoliosis Patients, Lumbar Spondylosis, Lumbar Spondylolisthesis, Cervical Spondylosis and Spondylolisthesis, Post Laminectomy Cervical Syndrome, Cervical Myelopathy
Interventions: Ready Set Recover; Behavioral
Lead sponsor: National University of Natural Medicine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Lumbar Spine Degenerative Changes
Interventions: Education/Self-efficacy, Education; Behavioral
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 18 Years to 80 Years
Enrollment: 260 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal, Intervertebral Disc Injury
Interventions: NSSD, Sham NSSD; Device
Lead sponsor: University of South Florida; Other
Eligibility: 18 Years to 65 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Stanford, California • Tampa, Florida

Conditions: Lumbar Spine Surgery, Chronic Low-back Pain, Postsurgical Pain
Interventions: Telehealth mindfulness-based intervention (MBI), Telehealth Education; Behavioral
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 67 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
Interventions: Erector Spinae Plane Block, Subcutaneous Anesthesia; Procedure
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Physical Capability Outcomes
Interventions: Not listed
Lead sponsor: Gundersen Lutheran Medical Foundation; Other
Eligibility: 18 Years to 60 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 6
States / cities: Denver, Colorado • Newark, Delaware • Tallahassee, Florida + 3 more

Conditions: Spine Surgery, Vision Impairment
Interventions: table tilt; Other
Lead sponsor: University of Medicine and Dentistry of New Jersey; Other
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 2
States / cities: Newark, New Jersey

Conditions: Lumbar Spine Degeneration
Interventions: saline 0.9%, Liposomal bupivacaine; Drug
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 34 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Opioid Dependence, Chronic Pain
Interventions: Ketamine, Placebo Comparator; Drug
Lead sponsor: Jacques E. Chelly; Other
Eligibility: 18 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Pain
Interventions: Ropivacaine (Epidural analgesia), Dexmedetomidine, Iohexol, QST Procedure; Drug · Procedure
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 21 Years to 75 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lumbar; Injury
Interventions: Trek for Surgical Success; Behavioral
Lead sponsor: Sara Davin, PsyD, MPH; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
Interventions: Propranolol Hcl 40mg Tab, Placebo oral tablet; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Lumbar Spondylolisthesis, Lumbar Spine Degeneration
Interventions: Not listed
Lead sponsor: Methodist Health System; Other
Eligibility: 18 Years to 85 Years
Enrollment: 3,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Lumbar Spine Injury
Interventions: Dantrolene, Placebo Oral Tablet; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 116 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Search by objective public record fields.

Non-pharmacological Treatment for Pain After Spine Surgery

Safety and Efficacy of DepoDur in Lumbar Spine Surgery Patients

Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery

Study of an Expandable Interbody Device for the Lumbar Spine

A Novel Method for Capturing the Visual Evoked Potential During Spine Surgery Under Total Intravenous Anesthesia

NOCISCAN-Lumbar Spine (LS) Clinical Evaluation Study

Physical Activity Intervention for Patients Following Lumbar Spine Surgery

Telehealth Activity Intervention After Lumbar Spine Surgery

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis

Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover

Increasing Long-Term Physical Activity After Lumbar Spine Surgery

Non-surgical Spinal Decompression Therapy and Outcomes

Telehealth Mindfulness After Spine Surgery

Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

Physical Capability Outcomes After Single-Level PD-L vs Single-Level ALIF: a Multi-Center Clinical Trial

Intraocular Pressure During Prone Spinal Surgery

A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

Contrast and Anesthetic Level With Lumbar Erector Spinae Plan (ESP) Block

A Single Session Pain Psychology Class for Spine Surgery Patients

Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery

Comparison of Complication Rates Between Initial and Re-operative Anterior Lumbar Interbody Fusion Surgery: Is There a Difference?

The Use of Dantrolene to Improve Analgesia in Posterior Lumbar Surgery