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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mastalgia Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Pain in Breast Surgery Intervention

NCT04058938
View directory record Official record
Conditions
Opioid Use, Pain, Postoperative
Interventions
Educational handout instrument, Control
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 27, 2020 · Synced Sep 7, 2026, 2:03 PM EDT
Terminated Phase 3 Interventional Results available

D-cycloserine in the Management of Chemotherapy-Induced Peripheral Neuropathic Pain

NCT00301080
View directory record Official record
Conditions
Neurotoxicity, Pain, Breast Cancer
Interventions
D-cycloserine, Placebo
Drug · Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
2
States / cities
Chicago, Illinois • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 1, 2013 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

An Open-Label, MultiCenter Evaluation of the Use of Topically Administered FP1198 in Subjects With Pain Associated With Cyclic Mastalgia

NCT01105793
View directory record Official record
Conditions
Moderate to Severe Cyclic Mastalgia
Interventions
Danazol
Drug
Lead sponsor
FemmePharma Global Healthcare, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
4
States / cities
San Diego, California • Denver, Colorado • Lexington, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 25, 2011 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Not applicable Interventional

Calming Alternatives Learned During MRI-Guided Breast Biopsy

NCT03877146
View directory record Official record
Conditions
Breast Cancer, Breast Pain, Pain, Acute, Anxiety, Coping Skills, Self Efficacy
Interventions
Controlled Breathing Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 24, 2020 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Randomized Clinical Trial of Vitamin E and Evening Oil of Primrose for the Managment of Breast Pain

NCT00275600
View directory record Official record
Conditions
Cyclical Breast Pain
Interventions
Vitamin E, Evening Oil of Primrose, and Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 56 Years · Female only
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 25, 2009 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2 Interventional

A Study of Topical Danazol for the Treatment of Pain Associated With Fibrocystic Breast Disease

NCT00744276
View directory record Official record
Conditions
Fibrocystic Disease of Breast
Interventions
danazol, Placebo
Drug
Lead sponsor
FemmePharma Global Healthcare, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Beverly Hills, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 26, 2010 · Synced Sep 7, 2026, 2:03 PM EDT
Not listed Phase 3 Interventional

Study for Treatment of Moderate or Severe, Periodic, "Cyclic", Breast Pain

NCT00237523
View directory record Official record
Conditions
Fibrocystic Disease of Breast, Fibrocystic Changes of Breast, Fibrocystic Mastopathy, Pain
Interventions
IoGen (molecular iodine)
Drug
Lead sponsor
Symbollon Pharmaceuticals
Industry
Eligibility
18 Years to 50 Years · Female only
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
39
States / cities
Huntsville, Alabama • Phoenix, Arizona • Tucson, Arizona + 35 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2007 · Synced Sep 7, 2026, 2:03 PM EDT
Not listed Not applicable Interventional

Exercise Program or Health Education Program in Reducing Fatigue and Pain in Breast Cancer Survivors

NCT00336089
View directory record Official record
Conditions
Breast Cancer, Cancer Survivor, Fatigue, Pain
Interventions
exercise intervention, educational intervention, complementary or alternative medicine procedure, fatigue assessment and management, management of therapy complications, pain therapy, quality-of-life assessment
Behavioral · Other · Procedure
Lead sponsor
Clayton State University
Other
Eligibility
18 Years to 60 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
2
States / cities
Atlanta, Georgia • Morrow, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 16, 2013 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2 Interventional Results available

NOLAN: Naproxen or Loratadine and Neulasta

NCT01712009
View directory record Official record
Conditions
Bone Pain in Stage I - III Breast Cancer
Interventions
Naproxen, Loratadine, Pegfilgrastim, Chemotherapy
Drug · Biological
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 100 Years · Female only
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
83
States / cities
Muscle Shoals, Alabama • Anaheim, California • Fullerton, California + 78 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2018 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2 Interventional Results available

Effect of Patient Education on Reported Bone Pain in Breast Cancer Patients Receiving Chemotherapy and Pegfilgrastim

NCT01752907
View directory record Official record
Conditions
Breast Cancer
Interventions
General Education DVD, Bone Pain Education DVD
Other
Lead sponsor
Amgen
Industry
Eligibility
18 Years to 99 Years · Female only
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
51
States / cities
Fountain Valley, California • Mission Hills, California • Santa Rosa, California + 48 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2022 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 4 Interventional Results available

The Use Of Liposomal Bupivacaine For Pain Control

NCT03722927
View directory record Official record
Conditions
Pain, Breast
Interventions
Bupivacaine, Liposomal Bupivacaine
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 2 Interventional Results available

PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery

NCT03084536
View directory record Official record
Conditions
Breast Cancer, Breast Cancer Female, Cancer of Breast
Interventions
Bupivacaine, Gabapentin, Celecoxib, Acetaminophen, Midazolam, Fentanyl
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 23, 2024 · Synced Sep 7, 2026, 2:03 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Treatment of Breast Pain Using A Medication (Diclofenac) Applied to the Skin

NCT00276419
View directory record Official record
Conditions
Breast Pain, Non-cyclical Mastalgia, Surgical Scar-Related Breast Pain
Interventions
Diclofenac, Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 19, 2012 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 4 Interventional Results available

Symptom Management After Breast Cancer Surgery

NCT00686127
View directory record Official record
Conditions
Neuropathic Pain, Postmastectomy Pain
Interventions
Lidoderm patch, Placebo patch
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 27, 2018 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 4 Interventional

Prevention of Post-Mastectomy Breast Pain Using Ambulatory Continuous Paravertebral Blocks

NCT01231204
View directory record Official record
Conditions
Paravertebral Catheter Insertion, Mastectomy, Breast Cancer
Interventions
Placebo (normal saline) Continuous Infusion, Ropivicaine 0.4% Continuous Infusion
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2016 · Synced Sep 7, 2026, 2:03 PM EDT
Completed No phase listed Observational

Pilot Functional Imaging Study to Evaluate Mechanisms Underlying Chronic Pain in Breast Cancer Patients

NCT01639417
View directory record Official record
Conditions
Pain, Breast Cancer
Interventions
Not listed
Lead sponsor
Lynn Henry
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 14, 2016 · Synced Sep 7, 2026, 2:03 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Hormones, Outcomes, and Pain Pathways in Exercise Study

NCT07579182
View directory record Official record
Conditions
Breast Pain, Mastalgia, Back Pain, Back Pain, Low, Neck Pain, Chest Pain, Activity, Motor, Healthy Aging, Weight, Body, Inflammation, Gonadal Steroid Hormones, Neuronal Plasticity, Neuromuscular Manifestations
Interventions
Interventional Sports bra
Other
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 60 Years · Female only
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Phase 4 Interventional

Premedication to Reduce Discomfort With Screening Mammography

NCT00382083
View directory record Official record
Conditions
Breast Pain
Interventions
1000 mg acetaminophen, 800 mg ibuprofen, 1 oz 4% lidocaine gel
Drug
Lead sponsor
Mountain States Tumor and Medical Research Institute
Other
Eligibility
30 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Boise, Idaho
Source: ClinicalTrials.gov public record
Updated Sep 27, 2006 · Synced Sep 7, 2026, 2:03 PM EDT
Withdrawn Not applicable Interventional

Mastalgia Treatment: Is There a Role for Osteopathic Manipulative Treatment

NCT01643837
View directory record Official record
Conditions
Mastalgia
Interventions
Osteopathic Manipulative Treatment, Osteopathic Manipulative Light Touch Protocol (LT)
Other
Lead sponsor
New York Institute of Technology
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Central Islip, New York • Old Westbury, New York
Source: ClinicalTrials.gov public record
Updated Feb 15, 2022 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Not applicable Interventional

Qigong For PPSP In Breast Cancer Pain In Breast Cancer Survivors

NCT02848989
View directory record Official record
Conditions
Breast Cancer Surgery Pain, Breast Cancer, Stage 0-III Breast Cancer
Interventions
Qigong Mind-Body Exercise
Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 7, 2023 · Synced Sep 7, 2026, 2:03 PM EDT
Not listed Phase 4 Interventional

ICNBs for Post-op Pain in Breast Surgery

NCT04606836
View directory record Official record
Conditions
Pain, Postoperative, Length of Stay
Interventions
Bupivacaine Hydrochloride
Drug
Lead sponsor
Christine M. Kleinert Institute for Hand and Microsurgery
Other
Eligibility
20 Years to 70 Years · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
New Albany, Indiana • Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 8, 2020 · Synced Sep 7, 2026, 2:03 PM EDT
Active, not recruiting Not applicable Interventional

Curcumin in Reducing Joint Pain in Breast Cancer Survivors With Aromatase Inhibitor-Induced Joint Disease

NCT03865992
View directory record Official record
Conditions
Breast Cancer, Joint Pain
Interventions
Curcumin, Placebo, Nanoemulsion, Quality-of-Life Assessment, Questionnaire
Dietary Supplement · Other · Behavioral
Lead sponsor
City of Hope Medical Center
Other
Eligibility
Female only
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
4
States / cities
Duarte, California • Rancho Cucamonga, California • South Pasadena, California + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Not applicable Interventional

A Randomized Double-blind, Placebo Controlled, Multi-center Study to Evaluate the Safety, Tolerability and Potential Effects of the Dietary Supplement Violet™ Molecular Iodine (I2) on Breast Health in Women With Cyclic Breast Discomfort and Tenderness

NCT02676336
View directory record Official record
Conditions
Fibrocystic Breast Condition (FBC)
Interventions
Violet™ Molecular Iodine (I2), Placebo
Dietary Supplement · Other
Lead sponsor
BioPharmX, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jul 9, 2018 · Synced Sep 7, 2026, 2:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Acupuncture for Non-cyclical Breast Pain

NCT00275574
View directory record Official record
Conditions
Breast Pain
Interventions
acupuncture
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 31, 2015 · Synced Sep 7, 2026, 2:03 PM EDT