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ClinicalTrials.gov public records Last synced May 21, 2026, 11:40 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Mechanical Ventilation Clear all
Completed No phase listed Observational
View directory record Official record
Conditions
Mechanically Ventilated ICU Patients
Interventions
Not listed
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 2, 2014 · Synced May 21, 2026, 11:40 PM EDT
Not listed Not applicable Interventional
View directory record Official record
Conditions
Critically Ill
Interventions
Once daily screening, Twice daily screening, PS SBTs, T-piece SBTs
Procedure
Lead sponsor
Unity Health Toronto
Other
Eligibility
16 Years and older
Enrollment
760 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
5
States / cities
Long Beach, California • Los Angeles, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 4, 2018 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Mechanical Ventilation Complication, Upper Airway Obstruction
Interventions
nasal mask, full face mask
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Respiratory Failure
Interventions
Proloquo2Go, Standard of Care
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced May 21, 2026, 11:40 PM EDT
Withdrawn Not applicable Interventional
View directory record Official record
Conditions
Obesity
Interventions
Positive end-expiratory pressure (PEEP), ZEEP
Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Surrogate Decision Makers, Prolonged Mechanical Ventilation
Interventions
Decision aid, Usual care
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
416 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Aging, Respiration, Artificial
Interventions
SAT: Spontaneous Awakening Trial, SBT: Spontaneous Breathing Trial
Procedure
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years and older
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
4
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 10, 2009 · Synced May 21, 2026, 11:40 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Awareness, Mechanical Ventilation, Intubation Complication, PTSD
Interventions
Standard neuromuscular blocker practices, Education
Other · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
3,090 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
4
States / cities
Iowa City, Iowa • Minneapolis, Minnesota • Camden, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Cardiorespiratory Failure
Interventions
Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 2, 2023 · Synced May 21, 2026, 11:40 PM EDT
Terminated Not applicable Interventional Results available
View directory record Official record
Conditions
Severe Sepsis
Interventions
S.A.F.E.BT
Device
Lead sponsor
B. Braun Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
2
States / cities
Lexington, Kentucky • Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced May 21, 2026, 11:40 PM EDT
Terminated Phase 4 Interventional Results available
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
Combivent Respimat via tee adapter, Combivent Respimat via ventilator adapter
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
40 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
2
States / cities
Danbury, Connecticut • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2025 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Mechanical Ventilation Complication
Interventions
Tube Fastener, Adhesive Tape
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 99 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced May 21, 2026, 11:40 PM EDT
Completed Phase 4 Interventional Results available
View directory record Official record
Conditions
Depression
Interventions
Escitalopram, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
25 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced May 21, 2026, 11:40 PM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Chronic Critical Illness, Prolonged Mechanical Ventilation
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
589 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
6
States / cities
Denver, Colorado • The Bronx, New York • Chapel Hill, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2021 · Synced May 21, 2026, 11:40 PM EDT
Terminated Not applicable Interventional
View directory record Official record
Conditions
Mechanical Ventilation, Nonverbal Communication, Intratracheal Intubation, Critical Illness
Interventions
Brain Computer Interface (BCI) device, Communication picture board
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced May 21, 2026, 11:40 PM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Bronchopulmonary Dysplasia
Interventions
Azithromycin, Placebo
Drug
Lead sponsor
Hubert Ballard
Other
Eligibility
Up to 72 Hours
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2012
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 26, 2018 · Synced May 21, 2026, 11:40 PM EDT
Active, not recruiting Not applicable Interventional
View directory record Official record
Conditions
Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
Interventions
PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Coronary Artery Disease, Heart Failure
Interventions
continuous, mechanical ventilatory support
Procedure
Lead sponsor
Aurora BayCare Medical Center
Other
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Green Bay, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 13, 2018 · Synced May 21, 2026, 11:40 PM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Respiratory Failure, Mechanical Ventilation, Critical Illness
Interventions
Volume control, Pressure control, Adaptive pressure control
Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
4,785 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
4
States / cities
Chicago, Illinois • Baltimore, Maryland • Winston-Salem, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced May 21, 2026, 11:40 PM EDT
Withdrawn Phase 2Phase 3 Interventional
View directory record Official record
Conditions
Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
Interventions
High Frequency Percussive Ventilation
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced May 21, 2026, 11:40 PM EDT
Enrolling by invitation Not applicable Interventional
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
Interventions
Low-flow ECMO
Device
Lead sponsor
Institute for Extracorporeal Life Support
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
Interventions
Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
Device · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 100 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 13, 2020 · Synced May 21, 2026, 11:40 PM EDT
Terminated Phase 2 Interventional Results available
View directory record Official record
Conditions
Coronavirus Infections, Pneumonia, Viral, Acute Respiratory Distress Syndrome
Interventions
Nitric Oxide
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
2
States / cities
Shreveport, Louisiana • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced May 21, 2026, 11:40 PM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Critical Illness
Interventions
Protocolized Sedation, Protocolized sedation, with daily interruption
Procedure
Lead sponsor
Mount Sinai Hospital, Canada
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
2
States / cities
Long Beach, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced May 21, 2026, 11:40 PM EDT