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ClinicalTrials.gov public records Last synced Nov 6, 2026, 1:18 AM EST

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Showing 1–24 of 64 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mechanical Ventilation Complication Clear all

Conditions: Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication, ICU Acquired Weakness, Pain
Interventions: Realtime audit and feedback, RN Implementation Facilitator; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 19 Years and older
Enrollment: 16,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 3
States / cities: Iowa City, Iowa • Omaha, Nebraska • Columbus, Ohio

Conditions: Mechanical Ventilation Complication
Interventions: intermittent IV CLON; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 1 Day to 12 Months
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mechanical Ventilation Complication, Complementary Health Approach
Interventions: Reiki therapy, Sham Reiki; Other
Lead sponsor: Ohio State University; Other
Eligibility: 55 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: One-Lung Ventilation
Interventions: PEEP level, Use of recruitment maneuvers; Procedure
Lead sponsor: Technische Universität Dresden; Other
Eligibility: 18 Years and older
Enrollment: 2,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 3
States / cities: Boston, Massachusetts • New York, New York • Cleveland, Ohio

Conditions: ARDS, Human, Lung Injury, Acute, Respiratory Distress Syndrome, Mechanical Ventilation Complication, Alveolar Edema, Right Heart Failure, Right Ventricular Dysfunction
Interventions: PEEP ARDSnet, PEEP LRM; Procedure
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
Interventions: Ibuprofen and acetaminophen, Ibuprofen and placebo; Drug
Lead sponsor: University of South Alabama; Other
Eligibility: 5 Days to 21 Days
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Mobile, Alabama

Conditions: Respiratory Insufficiency, Respiratory Failure, Mechanical Ventilation Complication
Interventions: Patients given EMV Ventilation; Device
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Complication of Ventilation Therapy
Interventions: Not listed
Lead sponsor: University of California, San Diego; Other
Eligibility: 18 Years and older
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature, Bronchopulmonary Dysplasia
Interventions: Hydrocortisone, Placebo; Drug
Lead sponsor: NICHD Neonatal Research Network; Network
Eligibility: Up to 30 Weeks
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2024
U.S. locations: 20
States / cities: Birmingham, Alabama • Los Angeles, California • Palo Alto, California + 16 more

Conditions: Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
Interventions: Not listed
Lead sponsor: Interfaith Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Mechanical Ventilation Complication, Upper Airway Obstruction
Interventions: nasal mask, full face mask; Procedure
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Robotic Surgery, Mechanical Ventilation
Interventions: Mechanical Ventilation; Other
Lead sponsor: Hospital Israelita Albert Einstein; Other
Eligibility: 18 Years and older
Enrollment: 1,015 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 4
States / cities: San Francisco, California • Boston, Massachusetts • Rochester, Minnesota + 1 more

Conditions: Prematurity, Apnea, Respiratory Failure
Interventions: Caffeine citrate, Normal saline; Drug · Other
Lead sponsor: University of Miami; Other
Eligibility: 1 Day to 5 Days
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Critical Illness, Mechanical Ventilation Complication, Delirium, Cognitive Impairment
Interventions: Post-ICU Problem Solving; Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: 55 Years to 89 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Covid19, Cytokine Storm, Mechanical Ventilation Complication
Interventions: Anakinra, 0.9% Saline; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 89 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: New York, New York

Conditions: Respiratory Insufficiency, Extracorporeal Membrane Oxygenation Complication, Mechanical Ventilation Pressure High
Interventions: Ultra-Protective Ventilation Facilitated by Extracorporeal Support, Lung-Protective Ventilation (LPV), Driving Pressure-Limited Ventilation (DPL), Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS), Early Cohort corticosteroid dose, Extended Cohort corticosteroid dose, Usual care without routine corticosteroids, Usual care without extending corticosteroids, Usual care with fludrocortisone, Usual care without fludrocortisone, Drug 4 mL:, Drug 40 mg:, PEEP-20, PEEP-AOP, PEEP-10, VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation, Electrical impedance tomography (EIT), no treatment / intervention arm is involved., Usual care, Early Routine IMT; Other · Drug
Lead sponsor: University Health Network, Toronto; Other
Eligibility: 18 Years and older
Enrollment: 6,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 27
States / cities: Tucson, Arizona • Los Angeles, California • San Diego, California + 20 more

Conditions: Oral Bacterial Infection, Mechanical Ventilation Complication
Interventions: SwishKit + Oral care treatment as usual, Oral care treatment as usual; Device · Procedure
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Anesthesia Intubation Complication, Mechanical Ventilation Complication
Interventions: Assess for Audible Endotracheal Leak, Assess for Endotracheal Leak with direct visualization under rigid bronchoscope; Other
Lead sponsor: University of Mississippi Medical Center; Other
Eligibility: 1 Month to 8 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Mechanical Ventilation Complication
Interventions: Diaphragm Ultrasound; Procedure
Lead sponsor: Albert Einstein Healthcare Network; Other
Eligibility: 18 Years and older
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Acute Lung Injury, Mechanical Ventilation Complication, Dietary Modification
Interventions: Oxepa, Jevity 1.5; Other
Lead sponsor: Grace Hospital, Cleveland, Ohio; Other
Eligibility: 19 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2014
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Mechanical Ventilation Complication, Weaning Failure
Interventions: Plateau Pressure; Diagnostic Test
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 120 Years
Enrollment: 248 participants
Timeline: 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Gynecologic Cancer, Genitourinary Cancer
Interventions: Airway Pressure Release Ventilation, Conventional Mechanical Ventilation; Other
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Mechanical Ventilation Complication
Interventions: weaning; Procedure
Lead sponsor: University of California, Los Angeles; Other
Eligibility: Not listed
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mechanical Ventilation Complication
Interventions: CleanSweep Closed Suction System; Device
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 272 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Behavioral Economic & Staffing Strategies in the ICU

Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study

Reiki Intervention for Seriously Ill Elders Intensive Care Unit (RISE-ICU)

Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus

Entrainment-Based Mechanical Ventilation

Effect of Mode of Transport Ventilation on Respiratory Parameters After Cardiac Surgery

Hydrocortisone for BPD

Ketamine Infusion as Sedative Analgesic in Severe ARDS

Nasal Mask Ventilation During the Induction of General Anesthesia

Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery

Caffeine to Reduce Mechanical Ventilation in Preterm Infants

A Problem Solving Intervention for Post-ICU Cognitive Impairment in Older Adults

Anakinra, COVID-19, Cytokine Storm

Platform of Randomized Adaptive Clinical Trials in Critical Illness

Efficacy of A Novel RinSe Device to Reduce Oral Bacteria in Intubated IntEnsive CaRe Patients: a Pilot Study

Endotracheal Tube Audible Leak Test

Change In Diaphragmatic Thickness Predicts Extubation Success

Efficacy of Oxepa Enteral Feeding in LTAC (Long Term Acute Care Hospital) Patients on Chronic Ventilation- a Pilot Study

Preventing Failed Extubations

Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventila

Mechanical Ventilator Weaning in Chronically Ventilated Patients

Evaluation of the CleanSweep™ Closed Suction System on Length of Mechanical Ventilation and Ventilator-Associated Events