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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Molar Clear all
Recruiting Phase 4 Interventional Accepts healthy volunteers

Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

NCT04860141
View directory record Official record
Conditions
Dental Pain and Sensation Disorder, Pain, Postoperative
Interventions
Gabapentin 600mg, Placebo
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 59 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Triclosan Toothpaste and Third Molar Surgery

NCT01292343
View directory record Official record
Conditions
Dry Socket, Wound Infection
Interventions
Colgate Total Toothpaste, Colgate Regular Toothpaste
Other
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 35 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 27, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Recruiting Not applicable Interventional

Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

NCT06554366
View directory record Official record
Conditions
Pulp Necroses
Interventions
GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Combination of Buffered Anesthetic to Treat Mandibular Molars

NCT06047366
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis
Interventions
Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi, Mepivacaine plain
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Not applicable Interventional Results available

Ridge Preservation With Moldable Beta-tricalcium Phosphate Bone Substitute on Non-containable Non-Molar Extraction Sites

NCT03215667
View directory record Official record
Conditions
Alveolar Ridge Preservation, Dental Implants
Interventions
easy-graft CLASSIC (beta-Tricalcium Phosphate)
Device
Lead sponsor
Sunstar Americas
Industry
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 24, 2021 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional

Resin Polymer (NuSmile BioFlx) Compared to Stainless Steel Crowns (3M ESPE) for Restoration of Primary Molar Teeth

NCT06354634
View directory record Official record
Conditions
Dental Caries, Tooth Decay
Interventions
Resin polymer (NuSmile Bioflx) crown, Stainless steel crown
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Terminated Phase 2 Interventional

Safety and Efficacy Study of NTC-510 to Treat Pain Following Dental Surgery of Third Molars

NCT02161354
View directory record Official record
Conditions
Dental Pain
Interventions
NTC-510 capsules, Placebo Capsules, NTC-510A Capsules
Drug
Lead sponsor
NanoSHIFT LLC
Industry
Eligibility
18 Years to 45 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 22, 2017 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Dental Pain Study of Analgesics in Patients Undergoing Molar Removal

NCT03652818
View directory record Official record
Conditions
Dental Pain
Interventions
Pre-Op pregabalin, Pre-Op Placebo 1, Post-Op pregabalin, Post-Op Placebo 1, Post-Op Placebo 2, Post-Op acetaminophen
Drug
Lead sponsor
Nevakar, Inc.
Industry
Eligibility
17 Years to 55 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 22, 2021 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study Testing Ketamine Sublingual Wafer After Wisdom Tooth Extraction

NCT02356965
View directory record Official record
Conditions
Pain
Interventions
Ketamine, Placebo (for Ketamine)
Drug
Lead sponsor
iX Biopharma Ltd.
Other
Eligibility
18 Years to 38 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Recruiting No phase listed Observational

Impact of Cannabis Use During Third Molar Surgery

NCT07423195
View directory record Official record
Conditions
Cannabis Use, Marijuana Usage, Sedation and Analgesia, Wisdom Tooth
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
16 Years to 99 Years
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Surgery

NCT02096926
View directory record Official record
Conditions
Dental Pain
Interventions
Placebo, Ibuprofen
Drug
Lead sponsor
Lotus Clinical Research, LLC
Other
Eligibility
18 Years to 40 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Jul 22, 2026, 5:05 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Oral Specimen and Data Acquisition Study of Subjects Requiring Third Molar Removal

NCT01805869
View directory record Official record
Conditions
Stomatognatic, Tooth Diseases, Diseases, Tooth, Tooth Impaction
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
16 Years to 50 Years
Enrollment
3,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 2 Interventional

Rofecoxib to Prevent Pain After Third Molar (Wisdom Tooth) Extraction

NCT00026819
View directory record Official record
Conditions
Pain
Interventions
Rofecoxib
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 5:05 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Accuracy of Electronic Apex Locators ProMark, RootZX II and NRG Rider on Working Length of Multi-rooted Teeth

NCT02521909
View directory record Official record
Conditions
Dental Pulp Diseases
Interventions
ProMark (Tooth Extraction for Assessment of Different Apex Locators), Root ZX II (Tooth Extraction for Assessment of Different Apex Locators), NRG Rider (Tooth Extraction for Assessment of Different Apex Locators)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Jul 22, 2026, 5:05 PM EDT
Recruiting Phase 2 Interventional

A Study of LY4515100 in Participants With Pain Following Third Molar Removal

NCT07511816
View directory record Official record
Conditions
Acute Pain, Molar, Molar, Third, Surgery, Oral
Interventions
LY4515100, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 40 Years
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 30, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing a New Jaw Support Device During Third Molar Extractions

NCT03975920
View directory record Official record
Conditions
Impacted Third Molar Tooth, Temporomandibular Disorder
Interventions
The Restful Jaw Device
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 30 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
4
States / cities
Burnsville, Minnesota • Eden Prairie, Minnesota • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2022 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 3 Interventional Results available

Efficacy of 300 mg Ibuprofen Prolonged-Release Tablets for the Treatment of Pain After Surgical Removal of Impacted Third Molars

NCT03785756
View directory record Official record
Conditions
Pain
Interventions
Ibuprofen 300 mg Oral Tablet, Ibuprofen 200 mg Oral Tablet, Placebo of PR tablet, Placebo of IR tablet
Drug
Lead sponsor
Reckitt Benckiser Healthcare (UK) Limited
Industry
Eligibility
18 Years to 50 Years
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 2, 2024 · Synced Jul 22, 2026, 5:05 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

The Indications of First Molar Extraction at Tufts University, School of Dental Medicine

NCT04705181
View directory record Official record
Conditions
Tooth Extraction
Interventions
Not listed
Lead sponsor
Tufts University
Other
Eligibility
Not listed
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 18, 2025 · Synced Jul 22, 2026, 5:05 PM EDT
Not listed Not applicable Interventional

A Comparative Study of Hall Technique, Modified Hall Technique and Conventional Stainless-Steel Crown Restorations in the Treatment of Primary Molars With Proximal Caries Lesions.

NCT04822233
View directory record Official record
Conditions
Dental Caries
Interventions
Hall Technique (HT), Modified Hall Technique (MHT), Conventional Technique (CT)
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 8 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

A Study to Assess the Analgesic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extraction

NCT02199678
View directory record Official record
Conditions
Pain
Interventions
Placebo, ketamine 25 mg, ketamine 35 mg, ketamine 50 mg
Drug
Lead sponsor
Lotus Clinical Research, LLC
Other
Eligibility
18 Years to 38 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
2
States / cities
Pasadena, California • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 20, 2014 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Prospective Comparison of Indirect Pulp Therapy and Mineral Trioxide Aggregate Pulpotomy in Decayed Primary Molars

NCT02620826
View directory record Official record
Conditions
Dental Pulp Capping
Interventions
Indirect pulp therapy, Pulpotomy
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
2 Years to 12 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 5, 2024 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Exparel Versus Bupivacaine in Post-operative Pain Control

NCT06547255
View directory record Official record
Conditions
Liposomal Bupivacaine
Interventions
Bupivacaine liposome injectable suspension
Drug
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years to 80 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Phase 3 Interventional Results available

A Randomized, Self Controlled Clinical Study of Hemostatic Efficacy of the HemCon Dental Dressing

NCT00707486
View directory record Official record
Conditions
Tooth Extractions
Interventions
Hemcon Dental Dressing, Gauze with Pressure and/or Gelfoam
Device
Lead sponsor
HemCon Medical Technologies, Inc
Industry
Eligibility
14 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
2
States / cities
Milwaukie, Oregon • Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Jul 22, 2026, 5:05 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction

NCT06484439
View directory record Official record
Conditions
Pain, Post-operative, Third Molar, Oral Surgery, Pain, Acute
Interventions
Ketorolac, Oxycodone, Acetaminophen, Ibuprofen, Hydrocodone
Drug
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years to 44 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Jul 22, 2026, 5:05 PM EDT