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ClinicalTrials.gov public records Last synced May 22, 2026, 2:45 AM EDT

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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.

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Filters: Condition: Multiple Actinic Keratoses Clear all

Completed Phase 3 Interventional Results available

A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on AK on Face or Scalp

NCT03285477

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Conditions: Actinic Keratoses
Interventions: Placebo, KX2-391 Ointment 1%; Drug
Lead sponsor: Almirall, S.A.; Industry
Eligibility: 18 Years and older

Enrollment: 351 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 30
States / cities: Mobile, Alabama • Glendale, Arizona • Fremont, California + 27 more

Source: ClinicalTrials.gov public record

Updated Apr 12, 2021 · Synced May 22, 2026, 2:45 AM EDT

Recruiting Phase 3 Interventional

Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp

NCT07144345

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Conditions: Actinic Keratosis
Interventions: Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle containing excipients only (VEH) without active ingredient, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E; Drug · Other · Device
Lead sponsor: Sun Pharmaceutical Industries, Inc.; Industry
Eligibility: 18 Years to 85 Years

Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 10
States / cities: Fremont, California • Aventura, Florida • Rolling Meadows, Illinois + 7 more

Source: ClinicalTrials.gov public record

Updated Apr 21, 2026 · Synced May 22, 2026, 2:45 AM EDT

Recruiting Phase 3 Interventional

A Pilot Clinical Trial Comparing Topical Fluorouracil to Fluorouracil Plus Calcipotriene Field Treatments in Patients With Multiple Actinic Keratoses

NCT06851507

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Conditions: Multiple Actinic Keratoses
Interventions: Fluorouracil 5-FU, Fluorouracil/Calcipotriene; Drug
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older

Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Source: ClinicalTrials.gov public record

Updated May 12, 2026 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 2Phase 3 Interventional Results available

A Study to Evaluate Two Concentrations of DFD-07 Cream, in Subjects With Actinic Keratosis (AK) of the Face and/or Scalp Over a 12-week Treatment Period

NCT03116698

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Conditions: Actinic Keratosis (AK)
Interventions: Low dose DFD07 once daily, High dose DFD07 once daily, High dose DFD07 twice daily, Placebo twice daily; Drug
Lead sponsor: Dr. Reddy's Laboratories Limited; Industry
Eligibility: 18 Years to 65 Years

Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 20
States / cities: Cerritos, California • Fremont, California • Palm Springs, California + 14 more

Source: ClinicalTrials.gov public record

Updated Apr 23, 2019 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp

NCT00304239

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Conditions: Actinic Keratosis
Interventions: Metvix-PDT, Vehicle-PDT; Combination Product
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older

Enrollment: 131 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 4
States / cities: Naperville, Illinois • Louisville, Kentucky • Portland, Oregon + 1 more

Source: ClinicalTrials.gov public record

Updated Jul 2, 2023 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional

Metvix PDT Versus Vehicle PDT With Aktilite CL128 Lamp in Patients With Actinic Keratosis on the Face and Scalp

NCT00306800

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Conditions: Actinic Keratosis
Interventions: Photodynamic therapy with methyl aminolevulinate cream; Procedure
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older

Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 7
States / cities: St. Petersburg, Florida • New York, New York • Rochester, New York + 4 more

Source: ClinicalTrials.gov public record

Updated Feb 17, 2021 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 1 Interventional

Safety and Toleration of PEP005 Topical Gel When Applied to a Treatment Area of up to 100cm2

NCT00659893

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Conditions: Actinic Keratosis
Interventions: PEP005 Topical gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older · Male only

Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 8
States / cities: Tucson, Arizona • San Diego, California • Orange Park, Florida + 5 more

Source: ClinicalTrials.gov public record

Updated Sep 13, 2015 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional

Therapeutic Equivalence of Fluorouracil Cream, 5% Compared With Fluorouracil 5% Topical Cream of MylanPharmaceuticals Inc., U.S.A in the Treatment of Actinic Keratosis

NCT05078827

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Conditions: Actinic Keratoses
Interventions: Test Product (A): Fluorouracil Cream, 5% topical cream, Reference Product (B): Fluorouracil 5% Topical Cream of Mylan Pharmaceuticals Inc., Morgantown, WV 26505 U.S.A., Placebo Product (C): Test vehicle cream for fluorouracil 5% of Encube Ethicals Pvt. Ltd., India; Drug
Lead sponsor: Encube Ethicals Pvt. Ltd.; Industry
Eligibility: 18 Years and older

Enrollment: 458 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 7
States / cities: Bakersfield, California • Cerritos, California • Lauderdale Lakes, Florida + 3 more

Source: ClinicalTrials.gov public record

Updated Mar 13, 2023 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional

Therapeutic Equivalence of Diclofenac Sodium Gel 3% vs Solaraze ® in the Treatment of Actinic Keratosis

NCT03826550

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Conditions: Actinic Keratoses
Interventions: Diclofenac Sodium Gel, Solaraze 3% Topical Gel, Placebo; Drug · Other
Lead sponsor: Encube Ethicals Pvt. Ltd.; Industry
Eligibility: 18 Years and older

Enrollment: 655 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 24
States / cities: Bryant, Arkansas • San Ramon, California • Coral Gables, Florida + 20 more

Source: ClinicalTrials.gov public record

Updated Jan 31, 2019 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations

NCT00742391

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Conditions: Actinic Keratoses
Interventions: PEP005 (ingenol mebutate) Gel, Vehicle gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 255 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 18
States / cities: Mesa, Arizona • Denver, Colorado • Kissimmee, Florida + 14 more

Source: ClinicalTrials.gov public record

Updated Mar 5, 2015 · Synced May 22, 2026, 2:45 AM EDT

Recruiting Phase 3 Interventional

Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Upper Extremities

NCT07144852

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Conditions: Actinic Keratosis
Interventions: Reformulated Levulan Kerastick containing aminolevulinic acid hydrochloride (ALA HCl), 20%, Vehicle, Blue Light Photodynamic Therapy Illuminator device, BLU-U® model 4170E.; Drug · Other · Device
Lead sponsor: Sun Pharmaceutical Industries, Inc.; Industry
Eligibility: 18 Years to 85 Years

Enrollment: 260 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 20
States / cities: Phoenix, Arizona • Fremont, California • Castle Rock, Colorado + 17 more

Source: ClinicalTrials.gov public record

Updated Apr 21, 2026 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Multi-center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)

NCT00916006

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Conditions: Actinic Keratosis
Interventions: PEP005 Gel, Vehicle gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 269 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 19
States / cities: Los Angeles, California • Oceanside, California • San Diego, California + 16 more

Source: ClinicalTrials.gov public record

Updated Apr 1, 2015 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Multi-Center Study to Evaluate the Efficacy and Safety of KX2-391 Ointment 1% on Actinic Keratosis on Face or Scalp (AK004)

NCT03285490

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Conditions: Actinic Keratosis
Interventions: KX2-391 Ointment 1%, Placebo; Drug
Lead sponsor: Almirall, S.A.; Industry
Eligibility: 18 Years and older

Enrollment: 351 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 30
States / cities: Phoenix, Arizona • Tucson, Arizona • Hot Springs, Arkansas + 27 more

Source: ClinicalTrials.gov public record

Updated Mar 9, 2021 · Synced May 22, 2026, 2:45 AM EDT

Terminated Not applicable Interventional Results available

Treatment of Field Cancerization for Reduction in Tumor Burden - A Prospective Study

NCT02150863

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Conditions: Extensive Photodamage, Actinic Keratosis, History of Numerous Skin Cancers
Interventions: Ultrapulse Carbon Dioxide Laser, Cellutome epidermal harvesting system; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 85 Years

Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Boston, Massachusetts

Source: ClinicalTrials.gov public record

Updated Nov 17, 2019 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional

Bioequivalence Study to Compare Sol-Gel Technologies' 5-FU Cream With Efudex® (5-FU) Cream

NCT03727074

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Conditions: Actinic Keratosis (AK)
Interventions: 5-FU Cream, Efudex®, Vehicle; Drug
Lead sponsor: Sol-Gel Technologies, Ltd.; Industry
Eligibility: 18 Years and older

Enrollment: 462 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Cerritos, California

Source: ClinicalTrials.gov public record

Updated Mar 17, 2020 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional

A Multi-center Study to Evaluate the Safety and Efficacy of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on Non-head Locations (Trunk and Extremities)

NCT00917306

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Conditions: Actinic Keratosis
Interventions: PEP005 Gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 8
States / cities: Orange Park, Florida • Newnan, Georgia • Snellville, Georgia + 5 more

Source: ClinicalTrials.gov public record

Updated Apr 14, 2015 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 2 Interventional Results available

Short-incubation Levulan Photodynamic Therapy Versus Vehicle for Face/Scalp Actinic Keratosis (AK)

NCT01475955

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Conditions: Actinic Keratosis
Interventions: Broad Area ALA 1-hour incubation, Broad Area ALA 2 hour incubation, broad area ALA 3-hour incubation, Spot ALA 2 hour incubation, Vehicle PDT, Blue Light Treatment; Drug · Device
Lead sponsor: DUSA Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years and older

Enrollment: 235 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 13
States / cities: La Jolla, California • Los Angeles, California • San Diego, California + 10 more

Source: ClinicalTrials.gov public record

Updated Oct 27, 2016 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 1 Interventional

Pharmacokinetics of Ingenol Mebutate Gel in Actinic Keratosis Under Maximum Use Conditions

NCT02124239

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Conditions: Actinic Keratosis
Interventions: Ingenol mebutate; Drug
Lead sponsor: LEO Pharma; Industry
Eligibility: 18 Years and older

Enrollment: 79 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Source: ClinicalTrials.gov public record

Updated Feb 23, 2025 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 2 Interventional

Study to Determine the Safety of PEP005 0.025% and 0.05% Topical Gel in Patients With Actinic Keratoses

NCT00375739

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Conditions: Actinic Keratosis
Interventions: PEP005; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 24
States / cities: Huntsville, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 20 more

Source: ClinicalTrials.gov public record

Updated Jan 27, 2016 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Multicenter Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel When Used to Treat Actinic Keratoses (AKs) on the Non Head Locations

NCT00942604

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Conditions: Actinic Keratoses
Interventions: PEP005 (ingenol mebutate) Gel, Vehicle gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 203 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 17
States / cities: Hot Springs, Arizona • San Diego, California • Alpharetta, Georgia + 14 more

Source: ClinicalTrials.gov public record

Updated Mar 5, 2015 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Multi-Center Study to Evaluate the Efficacy and Safety of PEP005 (Ingenol Mebutate) Gel, When Used to Treat Actinic Keratoses on the Head (Face or Scalp)

NCT00915551

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Conditions: Actinic Keratosis
Interventions: PEP005 (Ingenol Mebutate) gel, 0.015%, Vehicle Gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 278 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 19
States / cities: Hot Springs, Arizona • Fremont, California • Jacksonville, Florida + 16 more

Source: ClinicalTrials.gov public record

Updated Mar 5, 2015 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 3 Interventional Results available

A Study Comparing Diclofenac Sodium Gel 3% to Solaraze® (Diclofenac Sodium) Gel 3% in the Treatment of Actinic Keratosis

NCT01962987

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Conditions: Actinic Keratosis
Interventions: Diclofenac sodium, Placebo; Drug · Other
Lead sponsor: Actavis Inc.; Industry
Eligibility: 18 Years to 75 Years

Enrollment: 476 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 31
States / cities: Fremont, California • Long Beach, California • Newport Beach, California + 27 more

Source: ClinicalTrials.gov public record

Updated Jul 19, 2020 · Synced May 22, 2026, 2:45 AM EDT

Completed Phase 2 Interventional

A Study to Examine the Safety and Toleration of PEP005 Topical Gel in Patients With Actinic Keratoses on the Top of the Hand

NCT00544297

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Conditions: Actinic Keratosis
Interventions: PEP005 gel; Drug
Lead sponsor: Peplin; Industry
Eligibility: 18 Years and older

Enrollment: 12 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 4
States / cities: San Diego, California • Snellville, Georgia • San Antonio, Texas + 1 more

Source: ClinicalTrials.gov public record

Updated Apr 1, 2015 · Synced May 22, 2026, 2:45 AM EDT

Not listed Phase 3 Interventional

T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum

NCT00002811

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Conditions: Precancerous Condition
Interventions: liposomal T4N5 lotion; Drug
Lead sponsor: Applied Genetics; Industry
Eligibility: 2 Years to 60 Years

Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1996
U.S. locations: 7
States / cities: Miami Beach, Florida • Ann Arbor, Michigan • Minneapolis, Minnesota + 4 more

Source: ClinicalTrials.gov public record

Updated Nov 5, 2013 · Synced May 22, 2026, 2:45 AM EDT