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Showing 1–24 of 37 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Myofascial Trigger Point Pain Clear all
Completed Not applicable Interventional Results available

Onabotulinumtoxin A Versus Kenalog for Chronic Pelvic Pain

NCT02369068
View directory record Official record
Conditions
Pelvic Pain
Interventions
Onabotulinumtoxin A, Kenalog
Drug
Lead sponsor
Jamie Bartley, DO
Other
Eligibility
18 Years and older · Female only
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Phase 1 Interventional

Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain

NCT02173405
View directory record Official record
Conditions
Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Trigger Point Pain, Myofascial
Interventions
OnabotulinumtoxinA, Placebo
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
3
States / cities
Cleveland, Ohio • Mayfield Heights, Ohio • Westlake, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Jul 22, 2026, 2:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time

NCT00042276
View directory record Official record
Conditions
Neck Pain
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 65 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Analysis of Kinesio® Tape on Myofascial Pain Syndrome of the Iliotibial Band

NCT04531306
View directory record Official record
Conditions
Myofascial Trigger Point Pain
Interventions
Kinesio® Tape
Other
Lead sponsor
North Dakota State University
Other
Eligibility
18 Years to 30 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fargo, North Dakota
Source: ClinicalTrials.gov public record
Updated Feb 8, 2021 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Phase 2 Interventional

Study Evaluating Heated Lidocaine/Tetracaine Patch in Patients With Pain Associated With Myofascial Trigger Points

NCT01106989
View directory record Official record
Conditions
Myofascial Pain Syndromes
Interventions
Heated lidocaine/tetracaine patch
Drug
Lead sponsor
ZARS Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 15, 2012 · Synced Jul 22, 2026, 2:28 PM EDT
Enrolling by invitation Phase 2 Interventional

Investigating the Minimum Number of Needling Required to Optimize Trigger Point Injections Outcome

NCT04732507
View directory record Official record
Conditions
Myofascial Pain, Myofascial Trigger Point Pain
Interventions
1% plain lidocaine and 0.25% plain bupivacaine
Combination Product
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jul 22, 2026, 2:28 PM EDT
Terminated No phase listed Observational

Investigation of Hypermobility, Biomarkers, and Pain Generators in Chronic Pain Patients

NCT02761928
View directory record Official record
Conditions
Low Back Pain, Mechanical, Spinal Stenosis, Nerve Root Disorder, Radiculopathy, Cervical, Benign Hypermobility Syndrome
Interventions
Beighton score for hypermobility
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Dry Needling on Muscle Stiffness, Gait, Motion, and Strength in Healthy Individuals With Trigger Points

NCT03689283
View directory record Official record
Conditions
Trigger Point Pain, Myofascial
Interventions
Dry Needling, Sham Dry Needlling
Other
Lead sponsor
Regis University
Other
Eligibility
18 Years to 50 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Dry Needling Multifidus on Thickness of Transversus Abdominis in Healthy Individuals

NCT01734577
View directory record Official record
Conditions
Back Pain
Interventions
Dry needling, Sham needling
Procedure
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional

Dry Needling for Sub Acromial Pain Syndrome

NCT03442894
View directory record Official record
Conditions
Subacromial Impingement Syndrome
Interventions
Standard Physical Therapy Treatment, Dry Needling, Sham Dry Needling
Procedure
Lead sponsor
59th Medical Wing
Federal
Eligibility
18 Years to 65 Years
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 22, 2026, 2:28 PM EDT
Terminated Phase 4 Interventional Results available

Using Saline for Myofascial Pain Syndromes (USAMPS)

NCT02120261
View directory record Official record
Conditions
Myofascial Pain Syndrome
Interventions
Normal Saline, Lidocaine Hydrochloride, Triamcinolone acetonide
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Distraction for Anxiety Reduction During Trigger Points Procedures in Pain Medicine Clinic

NCT03334929
View directory record Official record
Conditions
Pain Management
Interventions
Virtual Reality headset
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Jul 22, 2026, 2:28 PM EDT
Not listed Not applicable Interventional

Botulinum Toxin Type A Versus Saline Trigger Point Injections for Myofascial Pelvic Pain

NCT01905137
View directory record Official record
Conditions
Myofascial Pelvic Pain
Interventions
Intervention-Botulinum Toxin Type A, placebo
Drug
Lead sponsor
Boston Urogynecology Associates
Other
Eligibility
18 Years and older · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 11, 2019 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Phase 2 Interventional Results available

Trigger Point Injection in Reducing Pain Following Total Knee Arthroplasty

NCT06955923
View directory record Official record
Conditions
Trigger Point Pain, Myofascial
Interventions
Trigger point injection (lidocaine), Sham Comparator
Drug · Other
Lead sponsor
David Grant U.S. Air Force Medical Center
Federal
Eligibility
45 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Fairfield, California
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 22, 2026, 2:28 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

OMTrigger Inject- Treating Trigger Points: Comparing Muscle Energy Technique vs. Lidocaine Needling Technique

NCT05009264
View directory record Official record
Conditions
Myofascial Pain Syndrome
Interventions
OMT
Procedure
Lead sponsor
AtlantiCare Regional Medical Center
Other
Eligibility
25 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Atlantic City, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Jul 22, 2026, 2:28 PM EDT
Not listed Phase 4 Interventional

Trigger Point Injections and Pelvic Rehabilitation for the Treatment of Pelvic Floor Myalgia and Sexual Pain

NCT02022722
View directory record Official record
Conditions
Dyspareunia
Interventions
Trigger Point Injections Triamcinolone Acetonide, Bupivacaine Hydrochloride, Pelvic Rehabilitation
Drug · Procedure
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 29, 2013 · Synced Jul 22, 2026, 2:28 PM EDT
Terminated Not applicable Interventional

Dry Needling and Functional Improvement

NCT02838394
View directory record Official record
Conditions
Myofascial Trigger Point Pain, Myofascial Pain Syndrome
Interventions
Dry needling, Sham dry needling
Procedure · Other
Lead sponsor
Brigham Young University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Jul 22, 2026, 2:28 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Ultrasound Imaging for Myofascial Pain

NCT05928884
View directory record Official record
Conditions
Chronic Low-back Pain, Myofascial Pain
Interventions
There is no intervention. It is a phenotyping study only
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
20 Years to 70 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 5, 2025 · Synced Jul 22, 2026, 2:28 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Trigger Point Injection for Myofascial Pain Syndrome in the Low Back: A Randomized Controlled Trial

NCT04704297
View directory record Official record
Conditions
Low Back Pain, Myofascial Pain Syndrome Lower Back
Interventions
Treatment of Myofascial Pain Syndrome in the low back. This intervention will be based on outcomes of the medications listed below., Evaluation of functional ability using a patient centered functional score known as the Modified Oswestry Disability Index (MODI). The intervention will be based on outcomes of medications below., Following up with participants 60-72 hours after treatment in the Emergency Department. This intervention will be based on outcomes of the medications listed below.
Drug
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jan 11, 2021 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Trigger Point Dry Needling With and Without Electrical Stimulation in Healthy Subjects

NCT07384247
View directory record Official record
Conditions
People With Identified Painful Trigger Points (Tp) Within the Soleus and Gastrocnemius Muscles Complex, Healthy Subjects or Volunteers
Interventions
Dry needling with electrical stimulation, Dry needling, Electrical stimulation, Sham
Procedure
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Immediate Effect of Dry Needling of the Lumbar Multifidus on Pain Sensitivity In A Healthy Population

NCT05845697
View directory record Official record
Conditions
Low Back Pain
Interventions
Trigger point dry needling, Sham dry needling
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Jul 22, 2026, 2:28 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Positional Release Therapy and Therapeutic Massage Reduce Muscle Trigger and Tender Points

NCT04765891
View directory record Official record
Conditions
Trigger Point Pain, Myofascial
Interventions
Positional release therapy, Therapeutic Massage
Other
Lead sponsor
Brigham Young University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Feb 22, 2021 · Synced Jul 22, 2026, 2:28 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department

NCT05151510
View directory record Official record
Conditions
Myofascial Trigger Point Pain, Myofacial Pain
Interventions
Trigger point injection with 1% lidocaine, Lidocaine patch 5%
Procedure · Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 2:28 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation

NCT03995641
View directory record Official record
Conditions
Postoperative Pain, Pelvic Organ Prolapse, Trigger Point Injection, Sacrospinous Ligament Fixation
Interventions
marcaine and kenalog
Drug
Lead sponsor
Kettering Health Network
Other
Eligibility
21 Years and older · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Dayton, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 4, 2025 · Synced Jul 22, 2026, 2:28 PM EDT