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Showing 1–24 of 78 matching trials from the live ClinicalTrials.gov search.
Recruiting Not applicable Interventional Accepts healthy volunteers

Timing Impact of Early vs. Late Cranioplasty on Hemicraniectomy Outcomes

NCT06632587
Conditions
Craniocerebral Trauma, Stroke, Intracranial Hemorrhages
Interventions
Early cranioplasty, Standard-of-care cranioplasty
Procedure
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Neurological Diseases
Interventions
"Low O.R. Traffic"
Behavioral
Lead sponsor
St. Joseph's Hospital and Medical Center, Phoenix
Other
Eligibility
18 Years and older
Enrollment
1,944 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Phoenix, Arizona
Conditions
Cerebral Aneurysm
Interventions
Option grid for cerebral aneurysm treatment, Control
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Lebanon, New Hampshire
Completed No phase listed Observational Results available

Post-op Crowd Sourcing Health Data Via Text-messaging

NCT03532256
Conditions
Orthopedic Surgery, Opioid Use, Acute Injuries Knee, Neurosurgery, Surgery
Interventions
Observation, Text to online survey, Bi-directional text script
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
127 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Conditions
Lumbar Spine Degeneration, Lumbar Spine Instability, Lumbar Spondylosis
Interventions
Text Message Group
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Conditions
Intracranial Neurosurgery
Interventions
dexmedetomidine, propofol
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Conditions
Neurosurgery
Interventions
Not listed
Lead sponsor
Swedish Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Conditions
Epilepsy
Interventions
Epilepsy surgery
Procedure
Lead sponsor
Wayne State University
Other
Eligibility
6 Months to 21 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Detroit, Michigan
Completed Phase 3 Interventional Results available

Topical Vancomycin for Neurosurgery Wound Prophylaxis

NCT02284126
Conditions
Infection, Surgery, Nervous System Diseases
Interventions
Vancomycin
Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
1,103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
New York, New York
Conditions
Suspected CSF Shunt Obstruction
Interventions
ShuntCheck-Micro-Pumper (SCMP), Imaging
Device
Lead sponsor
NeuroDx Development
Industry
Eligibility
35 Months to 29 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
11
States / cities
Wilmington, Delaware • Washington D.C., District of Columbia • Chicago, Illinois + 8 more
Conditions
Neurosurgery, Pain
Interventions
valdecoxib
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Seattle, Washington
Not yet recruiting No phase listed Observational

Real Time Craniotomy Planning Using Mixed Reality

NCT07468370
Conditions
Neurosurgery, Surgical Planning, Brain Tumor Adult, Craniotomy Tumor Removal Surgery
Interventions
Mixed Reality Glasses/Viewer, Survey using a questionnaire.
Device · Other
Lead sponsor
Brainlab AG
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Timeline
2026 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Brain Neoplasm, Malignant Glioma
Interventions
Cetuximab, Cetuximab-IRDye 800CW, Tumor resection
Biological · Drug · Procedure
Lead sponsor
Eben Rosenthal
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Palo Alto, California
Completed No phase listed Observational Accepts healthy volunteers

Hyperglycemia in Neurosurgery

NCT05236751
Conditions
Hyperglycemia, Postoperative Infection
Interventions
Not listed
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Conditions
Parkinson's Disease
Interventions
VY-AADC02, Sham (Placebo) Surgery
Biological · Other
Lead sponsor
Neurocrine Biosciences
Industry
Eligibility
40 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
11
States / cities
Irvine, California • Sacramento, California • San Francisco, California + 8 more
Completed Phase 2 Interventional Results available

TXA in Spinal Fusion

NCT04272606
Conditions
Degenerative Disc Disease
Interventions
Tranexamic Acid, Saline Solution, Visual Acuity Exam, 3 Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM)
Drug · Diagnostic Test
Lead sponsor
Catherine R. Olinger
Other
Eligibility
18 Years to 90 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Conditions
Symptomatic Lumbar Disc Herniation, Symptomatic Grade I Lumbar Spondylolisthesis
Interventions
Lumbar Discectomy, Single-level lumbar fusion
Procedure
Lead sponsor
Greenwich Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
12
States / cities
San Francisco, California • Greenwich, Connecticut • New Haven, Connecticut + 9 more
Conditions
Intracranial Pressure
Interventions
High Frequency Chest Wall Oscillation
Device
Lead sponsor
Hill-Rom
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
1
States / cities
Houston, Texas
Conditions
Pressure Ulcer
Interventions
DabirAIR alternating pressure overlay
Device
Lead sponsor
Dabir Surfaces Inc
Industry
Eligibility
18 Years and older
Enrollment
392 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Conditions
Intracranial Hemorrhage
Interventions
Apollo MIES, Medical Management
Device · Other
Lead sponsor
J. Mocco
Other
Eligibility
22 Years to 84 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
7
States / cities
Washington D.C., District of Columbia • Louisville, Kentucky • Buffalo, New York + 4 more
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting

NCT01474915
Conditions
Postoperative Nausea and Vomiting (PONV), Nausea
Interventions
Aprepitant, Ondansetron, Promethazine, Dexamethasone
Drug
Lead sponsor
Sergio Bergese
Other
Eligibility
18 Years to 85 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Conditions
Glioma, Glioblastoma, Metastatic Malignant Neoplasm in the Brain
Interventions
Microdialysis, Magnetic Resonance Imaging, Computed Tomography
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Conditions
Astrocytoma, Glioma
Interventions
5-Aminolevulinic Acid
Drug
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Baltimore, Maryland
Conditions
Epilepsy
Interventions
fMRI, Neuropsychological Testing, Additional electrode implantation, Electrical brain stimulation
Other
Lead sponsor
Northwell Health
Other
Eligibility
5 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2029
U.S. locations
1
States / cities
Great Neck, New York