Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:11 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 177 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Nicotine Dependence, Cigarettes Clear all

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Counseling Intervention, Information Intervention; Behavioral
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 13 Years to 18 Years
Enrollment: 1,058 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2010
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Nicotine Dependence
Interventions: e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 45 Years
Enrollment: 148 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Varenicline Pill, Contingency management, Counseling; Drug · Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 40 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Charleston, South Carolina • Lancaster, South Carolina • Pickens, South Carolina

Conditions: Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Interventions: Nicotine nasal spray 0.5 mg, Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 21 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Smoking Behaviors, Nicotine Dependence
Interventions: E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 256 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Tobacco Use Disorder
Interventions: Not listed
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2010
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence, Cigarettes
Interventions: AI-enhanced smartphone app, AI-enhanced smartphone app, but with delayed access; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 14 Years to 20 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Nicotine Dependence
Interventions: Zyban; Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 21 Years to 60 Years
Enrollment: 104 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2011
U.S. locations: 1
States / cities: West Los Angeles, California

Conditions: Nicotine Dependence
Interventions: Transcranial Magnetic Stimulation; Device
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 2
States / cities: Baltimore, Maryland • Catonsville, Maryland

Conditions: Nicotine Dependence
Interventions: Amphetamine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 49 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor, Nicotine Withdrawal
Interventions: SREC; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Smoking, Nicotine Dependence
Interventions: Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 21 Years and older
Enrollment: 799 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 6
States / cities: San Francisco, California • Minneapolis, Minnesota • Durham, North Carolina + 3 more

Conditions: Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
Interventions: Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
Interventions: Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples, Smoking-related Questionnaires; Other · Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: San Francisco, California

Conditions: E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions: Nicotine Replacement Therapies, Brief Behavioral Counseling; Drug · Behavioral
Lead sponsor: West Virginia University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Greenville, North Carolina • Morgantown, West Virginia

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Nicotine Replacement, Questionnaire Administration, Electronic Cigarette; Drug · Other · Device
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
Interventions: Mindfulness Training, Smoking Cessation Therapy; Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence
Interventions: Tobacco Cigarette, Electronic Cigarette; Device
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years and older
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Tobacco Use Disorder
Interventions: Varying the nicotine content of cigarettes, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 44 Years · Female only
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: E-cigarettes; Combination Product
Lead sponsor: Duke University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence, Tobacco Smoking
Interventions: Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 1,250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 10
States / cities: Phoenix, Arizona • San Francisco, California • Tampa, Florida + 7 more

Conditions: Alcoholism, Nicotine Dependence
Interventions: Varenicline; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Nicotine Dependence
Interventions: NJOY King 26 mg nicotine Electronic Nicotine Delivery System; Other
Lead sponsor: LA Clinical Trials; Other
Eligibility: 18 Years to 65 Years
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013
U.S. locations: 1
States / cities: Burbank, California

Conditions: Cigarette Smoking
Interventions: Smoking abstinence; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 70 Years
Enrollment: 305 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: San Francisco, California

Search by objective public record fields.

School Nurse-Delivered Smoking Cessation Intervention

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

E-cigarette Cessation in Adults Who Co-use Cannabis

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction

AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation

Brain Reaction to Treatment of Nicotine Dependence

Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction

Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers

Cigarette Harm Reduction With Electronic Cigarette Use

Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace

Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation

Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes

Mindfulness Training for Smoking Cessation

Clinical Pharmacology of Electronic Cigarettes

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

Project 2: Strategies for Reducing Nicotine Content in Cigarettes

Varenicline and Alcohol in Inpatient Addictions Program (IAP)

Evaluation of Short-term Safety and Use Patterns of an Electronic Nicotine Delivery System

Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence